Publication Cover
Accountability in Research
Ethics, Integrity and Policy
Volume 24, 2017 - Issue 2
425
Views
16
CrossRef citations to date
0
Altmetric
Articles

Conflict of Interest Policies and Industry Relationships of Guideline Development Group Members: A Cross-Sectional Study of Clinical Practice Guidelines for Depression

, Ph.D., , Ph.D., , M.S., , M.S., , M.S. & , Pharm.D., M.Med.Ed.
 

ABSTRACT

Because of increased attention to the issue of trustworthiness of clinical practice guidelines, it may be that both transparency and management of industry associations of guideline development groups (GDGs) have improved. The purpose of the present study was to assess a) the disclosure requirements of GDGs in a cross-section of guidelines for major depression; and, b) the extent and type of conflicts of panel members. Treatment guidelines for major depression were identified and searched for conflict of interest policies and disclosure statements. Multi-modal screens for undeclared conflicts were also conducted. Fourteen guidelines with a total of 172 panel members were included in the analysis. Eleven of the 14 guidelines (78%) had a stated conflict of interest policy or disclosure statement, although the policies varied widely. Most (57%) of the guidelines were developed by panels that had members with industry financial ties to drug companies that manufacture antidepressant medication. However, only a minority of total panel members (18%) had such conflicts of interest. Drug company speakers bureau participation was the most common type of conflict. Although some progress has been made, organizations that develop guidelines should continue to work toward greater transparency and minimization of financial conflicts of interest.

Acknowledgments

The authors would like to thank Darren Freeman-Coppadge, PharmD (University of Massachusetts Boston) for his assistance with data collection. The authors also thank Amy E. LeVertu of the Hirsh Health Sciences Library at Tufts University for her expertise, assistance, and support with the systematic review.

Funding

This work was supported by the Agency for Healthcare Research and Quality under Grant R03HS022940-01A1.

Notes

* References marked with an asterisk were for an analyzed CPG.

Additional information

Funding

This work was supported by the Agency for Healthcare Research and Quality under Grant R03HS022940-01A1.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.