Preparation of gelatin nanoparticles by two step desolvation method for application in photodynamic therapy

Janicy Arantes CarvalhoOrganic Synthesis Laboratory, Research and Development Institute – IPD, Vale do Paraíba University, São José dos Campos, Brazil

Alexandro Silva AbreuOrganic Synthesis Laboratory, Research and Development Institute – IPD, Vale do Paraíba University, São José dos Campos, Brazil

Vitória Tonini Porto FerreiraInstitute of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil

Erika Peterson GonçalvesOrganic Synthesis Laboratory, Research and Development Institute – IPD, Vale do Paraíba University, São José dos Campos, Brazil

Antonio Claudio TedescoChemistry Department, Photobiology and Photomedicine Group, University of São Paulo, Ribeirão Preto, Brazil

Juliana Guerra PintoPhotodynamic Therapy Laboratory, Research and Development Institute – IPD, Vale do Paraíba University, São José dos Campos, Brazil

Juliana Ferreira-StrixinoPhotodynamic Therapy Laboratory, Research and Development Institute – IPD, Vale do Paraíba University, São José dos Campos, Brazil

Milton Beltrame JuniorOrganic Synthesis Laboratory, Research and Development Institute – IPD, Vale do Paraíba University, São José dos Campos, Brazil

Andreza Ribeiro SimioniOrganic Synthesis Laboratory, Research and Development Institute – IPD, Vale do Paraíba University, São José dos Campos, BrazilCorrespondence[email protected]

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Abstract

Gelatin nanoparticles have recently been receiving considerable attention because they offer a good option as release systems due to their low cost, biocompatibility, biodegradability and its application in several types of formulations. This study aim was to evaluate the potential application of gelatin nanoparticles entrapping a photosensitizer in Photodynamic Therapy. Gelatin nanoparticles were studied by steady-state techniques and the biological activity evaluated by in vitro MTT assay. The particles were spherical in shape exhibiting a 273 nm diameter with a low tendency to aggregate. The loading efficiency was 76%. Photosensitizer photophysical properties were shown to be preserved after GN encapsulation. The cells viability obtaining 85% cells death compared with control. The results demonstrate that gelatin nanoparticles can be successfully applied for photosensitizers encapsulation or other active drugs and be used as an optimal medium for a variety of bioactive materials, which can also be encapsulated by the proposed method.

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Preparation of gelatin nanoparticles by two step desolvation method for application in photodynamic therapy

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Preparation of gelatin nanoparticles by two step desolvation method for application in photodynamic therapy

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