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ABSTRACT
Purpose: The purpose of this study was to investigate the self-microemulsifying drug delivery systems (SMEDDS) for ophthalmic delivery of Prednisolone (PDN) to treat uveitis.
Materials and methods: The pseudo-ternary phase diagrams were developed, and various SMEDDS were prepared using Linoleic acid as oil, Cremophore RH 40 as a surfactant, and propylene glycol as a co-surfactant. Physicochemical parameters (globule size, zeta potential, viscosity, and pH) and in vitro release of SMEDDS were studied. The in vivo efficacy of prepared formulations and the marketed drug solution was studied by administering them topically to an endotoxin-induced uveitis rabbit model.
Results: All formulations displayed an average globule size less than 100 nm. The developed SMEDDS exhibited acceptable physicochemical behavior and displayed sustained drug release. In vivo studies in a rabbit eye showed a marked improvement in the anti-inflammatory activity of developed formulation compared with a marketed formulation in a uveitis-induced rabbit eye model.
Conclusions: The developed SMEDDS are a feasible option to conventional eye drops for its capability to improve bioavailability via its longer precorneal residence time and its capacity to sustain the release of the drug.
Acknowledgments
We acknowledge the help of Department of Anatomy, AIIMS, New Delhi, India, School of Pharmaceutical Sciences, R.G.P.V, Bhopal, India in carrying out the TEM analysis and globule size analysis of samples, respectively.
Declaration of Interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.
Funding
The authors are grateful for financial support from AICTE, New Delhi, India in terms of a Junior Research Fellowship.