Serum chemerin level during the first trimester of pregnancy and the risk of gestational diabetes mellitus

Abstract

Objective: To investigate the association between chemerin level in the first trimester of pregnancy and the risk of gestational diabetes mellitus.

Methods: The blood samples of 212 women at 8–12 weeks of gestation were collected. After screening for gestational diabetes mellitus (GDM), 19 women with GDM and 20 women randomly selected from 144 women with normal glucose tolerance (NGT) were included in the study. Blood samples were collected from these women. Triglycerides, glucose, total cholesterol, and HDL cholesterol, LDL cholesterol, insulin and chemerin were measured. Gestational weight gain and body mass index was assessed.

Results: Serum levels of chemerin were significantly elevated during late gestation, and the risk of GDM was positively associated with maternal serum chemerin in the first trimester.

Conclusion: Serum chemerin level during the first trimester of pregnancy has the potential to predict risk of GDM.

Chinese abstract

目的：探讨妊娠期前三个月脂肪因子chemerin水平与妊娠期糖尿病风险之间的关联。

方法：收集212例妊娠8-12周妇女血样。在进行妊娠期糖尿病（GDM）筛查后, 选择19名GDM女性和从144名葡萄糖耐量正常（NGT）妇女中随机选择20位纳入本研究。收集上述受试者血样, 并测量甘油三酯、葡萄糖、总胆固醇、HDL胆固醇、LDL胆固醇、胰岛素和chemerin水平。评估妊娠期体重增加量和体质指数。

结果：妊娠晚期chemerin水平显著升高, 妊娠前三个月母体血清chemerin水平与GDM 发生风险呈正相关。

结论：妊娠前三月血清chemerin水平的检测有预测GDM发生风险的潜能。

Keywords:

• Body mass index
• chemerin
• gestational diabetes mellitus
• insulin resistance
• pregnancy

Acknowledgements

This work was supported by Natural Science Foundation of Hubei Province of China [2014CFB251], Hubei Province’s Outstanding Medical Academic Leader Program [WJ2015MA024] and Hubei Province Health and Family Planning Scientific Research project [JX6B105].

Declaration of interest

The authors report no conflicts of interest.