The effectiveness of transdermal testosterone gel 1% (androgel) for poor responders undergoing in vitro fertilization

Abstract

The study was conducted on 110 poor responders undergoing in vitro fertilization (IVF) from October 2015 to July 2016 at the IVF Center of Millitary Medical University, Vietnam. Its aim is to investigate the effectiveness of transdermal androgel before using controlled ovarian stimulation on patients undergoing IVF. A prospective, descriptive study was conducted to compare between the group of patients who used testosterone gel and the group of those who did not in terms of the following indicators: the number of oocytes retrieved, MII oocytes, fertilization rate, number of embryos, pregnancy rate, and embryo implantation rate. The number of oocytes retrieved, number of embryos, pregnancy rate, and embryo implantation rate of the group of patients using transdermal androgel before Controlled Ovarian Stimulation (COS) were found higher than those of the control group, with statistical significance. The use of androgel before stimulating ovarian can improve the responsiveness of poor responders when undergoing IVF.

Chinese abstract

本研究共纳入来自越南军事医学院辅助生殖（IVF）中心行体外受精的110名卵巢低反应患者。研究目的为探讨在患者未行控制性卵巢刺激前使用外用昂斯妥凝胶的疗效。本研究为一项前瞻性、描述性研究。将患者分为使用昂斯妥凝胶组和未使用组, 并分别检测两组以下指标：获卵数、MII期卵泡数、受精率、胚胎数、妊娠率和胚胎种植率。在行控制性卵巢刺激前使用昂斯妥凝胶组的获卵数、胚胎数、妊娠率及胚胎种植率均高于未使用组, 且两组间差异有统计学意义。对于行IVF的卵巢低反应患者, 在行控制性卵巢刺激前使用昂斯妥凝胶可提高患者的卵巢反应性。

Keywords:

• Androgel
• in vitro fertilization
• poor responder

Disclosure statement

The authors report no conflict of interest.