Effects of dehydroepiandrosterone supplementation on mice with diminished ovarian reserve

Abstract

Dehydroepiandrosterone (DHEA) has been used to improve the pregnancy rate in women with diminished ovarian reserve(DOR) during in vitro fertilization. We aimed to validate the effects of DHEA and identify the possible mechanisms. We constructed a mice model with DOR and analyzed the hormone parameters and follicle counts. In vivo experiment, FSH and LH concentrations in the serum were significantly elevated in the DOR group. However, the FSH and LH concentrations were partially reversed in the DOR + DHEA group. The E2, AMH and INHB were down-regulated in the DOR group and reversed in the DOR + DHEA group. Our study supported evidences that DHEA might modulate the hormone receptors in the ovary and hormone secretions to the peripheral circulation to regulate the ovary reserve functions.

Chinese abstract

脱氢表雄酮（DHEA）已用于提高体外受精期间卵巢储备降低（DOR）妇女的妊娠率。我们旨在验证DHEA的效果并确定可能的机制。我们构建了一个小鼠DOR模型并分析了其激素参数和卵泡计数。体内实验中, DOR组血清FSH和LH浓度显著升高。然而, DOR + DHEA组FSH和LH浓度部分逆转。E2, AMH和INHB在DOR组中下调, 在DOR + DHEA组中逆转。我们的研究支持DHEA可能调节卵巢激素受体和激素分泌物到外周循环以调节卵巢储备功能的证据。

Keywords:

• Dehydroepiandrosterone
• diminished ovarian reserve
• follicle-stimulating hormone

Disclosure statement

The authors declare that there is no conflict of interest regarding the publication of this paper.