Abstract
The US Capitol region ranks as one of the important biotech clusters in the US. This article documents the general dimensions of the innovative milieu and highlights the historical development of the cluster. The Capitol region biotechnology cluster, in essence, is the result of three reinforcing sets of factors: pre-existing resources, entrepreneurship and the incentives and infrastructure provided by government. Due to significant investments in science and technology the region was prepared to capitalize on technological opportunities in biotechnology as well as institutional policy changes that facilitated technology-based entrepreneurship.