Modulation of Platelet Aggregation Response by Factors Released from Polymorphonuclear Leukocytes

Abstract

Various studies, mostly done in vitro have suggested that there is interaction between platelets and polymorphonuclear leukocytes (PMNLs). Both the cells depending upon the experimental conditions release various mediators which modulate their reactivity. In the present review the effects of mediators released from PMNLs and their effect on platelet aggregation has been discussed. The present review summarizes various studies on the release of mediators such as free radicals, arachidonic acid and its metabolites, platelet activating factor, proteases, nitric oxide, ectonucleotidases and other uncharacterized factors from PMNLs. The effect of these mediators on the platelet aggregation response has also been discussed.

Keywords:

• Polymorphonuclear leukocytes
• Platelets
• Reactive oxygen species
• Platelet activating factor
• Arachidonic acid and its metabolites
• Proteases
• Nitric oxide and Ecto-ADPase