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Abstract
Two new triterpene fatty acid esters, 3β-palmityloxy-12,27-cyclofriedoolean-14-en-11α-ol (1) and 3β-palmityloxy-19α-hydroxyursane (2), together with 3β-hydroxy-11-oxo-olean-12-enyl palmitate (3) were isolated from the potent anti-inflammatory active fraction of the petroleum ether-soluble part of Cirsium setosum ethanol extract. Compound 1 was found to be a rare 12,27-cyclopropane triterpenoid. Their structures were determined through spectral data analysis combined with literature reports. Furthermore, in vitro experiment, compounds 1-3 exhibited significant inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages.
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No potential conflict of interest was reported by the author(s).
Additional information
Funding
This work was supported by the R & D program of Beijing Municipal Education Commission (No. 23JG0081)