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Research Articles

Ultrasonic-Mediated Green Synthesis of Novel S-Arylated-Pyridopyrimidines and Antimicrobial Evaluation against Escherichia coli and Staphylococcus aureus

, ORCID Icon, , ORCID Icon & ORCID Icon
Pages 6546-6553 | Received 26 Aug 2021, Accepted 17 Sep 2021, Published online: 06 Oct 2021
 

Abstract

A facile, eco-friendly and effective ultrasonic strategy to synthesize S-arylated-pyridopyrimidines is described starting from 4-thiol or 4-halogenopyridopyrimidines through a reaction involving a green procedure under ultrasonic irradiation and in presence of water as green solvent. The resulted derivatives were assessed for the antibacterial activity against different bacteria strains.

Graphical Abstract

Acknowledgment

Dr. Abuzer Ali is thankful to Taif University Researchers Supporting Project Number (TURSP-2020/124), Taif University, Taif, Saudi Arabia.

Disclosure statement

No potential conflict of interest was reported by the authors.

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