Synthesis, Characterization and Antifungal Evaluation of Novel Pyridazin-3(2H)-One Derivatives

Abstract

The electrophilicity of the functional groups of β-aroylpropionic acid 3 was utilized as a key starting material through the reaction with different nitrogen nucleophiles to synthesize novel various pyridazin-3(2H)-one derivatives as well as some condensed acyclic compounds. The chemical structures of the synthesized compounds were characterized by IR, ¹H NMR, ¹³C NMR, and mass spectra beside elemental analysis. The antifungal activity of the synthesized compounds against three types of fungus namely, Fusarium solani, Alternaria solani, and Fusarium semitectum realized that β-aroylpropionic acid 3, thiosemicarbazone derivative 8, and N-cyanoacetyl dihydropyridazinone derivative 17 displayed spectacular results for antifungal study and are worth being further evaluated in vivo and in the field.

Keywords:

• β-aroylpropionic acid
• 4,5-dihydropyridazin-3(2H)-one
• pyridazin-3(2H)-one
• antifungal activity

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Acknowledgments

The authors are gratefully acknowledged to Professor Dr. Hassan M. F. Madkour and Professor Dr. Ali Khalil Ali, Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt, for their faithful efforts to overcome some problems during the work.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Correction Statement

This article was originally published with errors, which have now been corrected in the online version. Please see Correction (http://dx.doi.org/10.1080/10406638.2022.2108598)