Three Component One-Pot Synthesis of Novel 8-Benzyloxy-5-{2-[N′-(1,3-Diphenyl-1H-Pyrazol-4-Ylmethylene)-Hydrazino]-Thiazol-4-yl}-3,4-Dihydro-1H-Quinolin-2-Ones

Abstract

Present investigation reported one-pot multicomponent synthesis of novel series of 8-benzyloxy-5-{2-[N′-(1,3-diphenyl-1H-pyrazol-4-ylmethylene)-hydrazino]-thiazol-4-yl}-3,4-dihydro-1H-quinolin-2-one derivatives. The titled compounds were synthesized by using one-pot condensation of substituted 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde, thiosemicarbazide, and 8-benzyloxy-5-(2-bromo-acetyl)-1H-quinolin-2-one. Main features of present protocol are environmentally benign, rapid and good to excellent yield of the products (93–99%).

Graphical Abstract

Keywords:

• 1-Aryl-1-phenyl-1H-pyrazole-4-carbaldehyde
• thiosemicarbazide
• orthophosphoric acid
• multicomponent reaction

Acknowledgments

The authors are thankful to Principal, Maulana Azad College Research Centre, Aurangabad for providing library and laboratory facilities for this work.

Disclosure statement

No potential conflict of interest was reported by the author(s).