Natural and Artificial Chiral-Based Systems for Separation Applications

Abstract

Chiral separation has attracted much attention for basic research and industrial applications in analytical chemistry. Generally, chiral separations use natural or artificial chiral-based materials as adsorbents. To improve the precision and efficiency of chiral separation, focus has shifted from natural and synthetic adsorbents to binary combinations of materials. This review specifically summarizes the significant advancements made in natural and artificial chiral adsorbents as promising candidates for diverse drug and biomolecule separation applications as well as the remaining drawbacks and challenges for research on chiral separations. The mechanisms of chiral-based recognition and separation and history and development of natural and artificial chiral-based systems are the focus of this review. Future directions in natural and artificial chiral-based systems for practical separations and other applications are also presented.

Keywords:

• Natural
• artificial
• chiral separation system
• application

Disclosure statement

The author(s) declare that they have no competing of interests.

Additional information

Funding

This work was supported by the National Key R&D Program of China (No. 2018YFC1602300), the National Natural Science Foundation of China (No. 31822040), the Young Top-Notch Talent of High-Level Innovation and Entrepreneurs Support Program (2017000026833ZK28), and School Level Cultivation Fund of Beijing Technology and Business University for Distinguished and Excellent Young Scholars (BTBUYP2020).