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Critical Reviews in Food Science and Nutrition Volume 58, 2018 - Issue 8
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Articles

Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment

Maria RussoInstitute of Food Sciences, National Research Council, Avellino, ItalyORCID Iconhttp://orcid.org/0000-0001-8385-9184
ORCID Icon,
Carmela SpagnuoloInstitute of Food Sciences, National Research Council, Avellino, Italy
,
Gian Luigi RussoInstitute of Food Sciences, National Research Council, Avellino, ItalyCorrespondence[email protected]
,
Krystyna Skalicka-WoźniakDepartment of Pharmacognosy with Medicinal Plants Unit, Medical University of Lublin, Lublin, PolandORCID Iconhttp://orcid.org/0000-0002-9313-5929
ORCID Icon,
Maria DagliaDepartment of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy
,
Eduardo Sobarzo-SánchezLaboratory of Pharmaceutical Chemistry, Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Spain
,
Seyed Fazel NabaviApplied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
&
Seyed Mohammad NabaviApplied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranCorrespondence[email protected]
 show all
Pages 1391-1405 | Published online: 21 Jul 2017
 
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ABSTRACT

In the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts in Brassica genus plants. Sulforaphane was found to be active against several forms of cancer. A growing body of data shows that sulforaphane acts against cancer at different levels, from development to progression, through pleiotropic effects. In this review, we discuss the available experimental and clinical data on the potential therapeutic role of sulforaphane against cancer. Its effects range from the protection of cells from DNA damage to the modulation of the cell cycle via pro-apoptotic, anti-angiogenesis and anti-metastasis activities. At molecular level, sulforaphane modulates cellular homeostasis via the activation of the transcription factor Nrf2. Although data from clinical studies are limited, sulforaphane remains a good candidate in the adjuvant therapy based on natural molecules against several types of cancer.

Conflicts of interest

The authors declare that there are no conflicts of interest.

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