The modulation and mechanism of probiotic-derived polysaccharide capsules on the immune response in allergic diseases

Abstract

Allergic diseases, derived from the dysregulation of immune tolerance mechanisms, have been rising in the last two decades. Recently, increasing evidence has shown that probiotic-derived polysaccharide capsules exhibit a protective effect against allergic diseases, involving regulation of Th1/Th2 balance, induction of differentiation of T regulatory cells and activation of dendritic cells (DCs). DCs have a central role in controlling the immune response through their interaction with gut microbiota via their pattern recognition receptors, including Toll-like receptors and C-type-lectin receptors. This review discusses the effects and critical mechanism of probiotic-derived polysaccharide capsules in regulating the immune system to alleviate allergic diseases. We first describe the development of immune response in allergic diseases and recent relevant findings. Particular emphasis is placed on the effects of probiotic-derived polysaccharide capsules on allergic immune response. Then, we discuss the underlying mechanism of the impact of probiotic-derived polysaccharide capsules on DCs-mediated immune tolerance induction.

Keywords:

• Allergic diseases
• dendritic cells
• immune regulation
• probiotic polysaccharides

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by Natural Science Foundation of Chongqing (Grant No.cstc2021jcyj-msxmX0712; cstc2021jcyj-msxmX0772), “One Belt and One Road” Education Cooperation Project (2021), Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJQN201900822; KJQN202100802), Chongqing Engineering Research Center for Processing & Storage of Distinct Agricultural Products (Grant No. KFJJ2019090), Chongqing Technology and Business University (Grant No. 1956024), and Fundamental Research Funds for the Central Universities (Grant No. SWU019026).