Resveratrol in disease prevention and health promotion: A role of the gut microbiome

Abstract

Resveratrol is a bioactive polyphenolic compound mainly present in grapes and red wine. It is known to exert beneficial effects in various experimental settings, such as antioxidant, anti-inflammatory, anti-proliferative, and immunoregulatory. Accumulating evidence suggests these health benefits might be, at least partially, attributed to resveratrol’s role in protecting the intestinal barrier, regulating the gut microbiome, and inhibiting intestinal inflammation. The purpose of this review is to examine the bioactivities of resveratrol in disease prevention and health promotion from the standpoint of regulating the gut microbiome. The article aims to provide additional insight into the potential applications of resveratrol in the food and nutraceutical industry.

Keywords:

• chronic disease prevention
• gut microbiome
• gut microbiota
• polyphenol
• resveratrol

Disclosure statement

No potential conflict of interest was reported by the authors.

Author contributions

Conceptualization, X.C., H.X., and X.W.; methodology, X.C., J.Z., N.Y., and X.W.; investigation, X.C., J.Z., N.Y., and X.W.; formal analysis, X.C., H.X., and X.W; validation, J.Z., P.W., F.L., H.X., and X.W.; visualization, J.Z. and J.L.; resources, X.C. and X.W.; writing—original draft preparation, X.C. and N.Y.; writing—review and editing, J.Z., P.W., F.L., S.D., H.X., and X.W.; supervision, H.X. and X.W.; funding acquisition, X.C. and X.W. All authors have read and agreed to the published version of the manuscript.

Additional information

Funding

This work was supported by a Miami University College of Education, Health, and Society Seed Grant (to X.W.), Natural Science Foundation of Guangdong Basic and Applied Basic Research Foundation (2021A1515010965, to X.C.), and General Project of Basic and Applied Basic Research in Guangzhou (202102080241, to X.C.).