Resveratrol in disease prevention and health promotion: A role of the gut microbiome

References

• Aguirre, L., A. Fernández-Quintela, N. Arias, and M. P. Portillo. 2014. Resveratrol: Anti-obesity mechanisms of action. Molecules (Basel, Switzerland) 19 (11):18632–55. doi: 10.3390/molecules191118632.
   PubMed Web of Science ®Google Scholar
• Alrafas, H. R., P. B. Busbee, M. Nagarkatti, and P. S. Nagarkatti. 2019. Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells. Journal of Leukocyte Biology 106 (2):467–80. doi: 10.1002/JLB.3A1218-476RR.
   PubMed Web of Science ®Google Scholar
• Altamemi, I., E. A. Murphy, J. F. Catroppo, E. E. Zumbrun, J. Zhang, J. L. McClellan, U. P. Singh, P. S. Nagarkatti, and M. Nagarkatti. 2014. Role of microRNAs in resveratrol-mediated mitigation of colitis-associated tumorigenesis in ApcMin/+ mice. The Journal of Pharmacology and Experimental Therapeutics 350 (1):99–109. doi: 10.1124/jpet.114.213306.
   PubMed Web of Science ®Google Scholar
• Aronne, L. J. 2002. Classification of obesity and assessment of obesity‐related health risks. Obesity Research 10 (S12):105S–15S. doi: 10.1038/oby.2002.203.
   PubMedGoogle Scholar
• Aron-Wisnewsky, J., C. Vigliotti, J. Witjes, P. Le, A. G. Holleboom, J. Verheij, M. Nieuwdorp, and K. Clément. 2020. Gut microbiota and human NAFLD: Disentangling microbial signatures from metabolic disorders. Nature Reviews. Gastroenterology & Hepatology 17 (5):279–97. doi: 10.1038/s41575-020-0269-9.
   PubMed Web of Science ®Google Scholar
• Arzola‐Paniagua, M. A., E. R. García‐Salgado López, C. G. Calvo‐Vargas, and M. Guevara‐Cruz. 2016. Efficacy of an orlistat‐resveratrol combination for weight loss in subjects with obesity: A randomized controlled trial. Obesity 24 (7):1454–63.
   PubMed Web of Science ®Google Scholar
• Azorín-Ortuño, M., M. J. Yáñez-Gascón, F. Vallejo, F. J. Pallarés, M. Larrosa, R. Lucas, J. C. Morales, F. A. Tomás-Barberán, M. T. García-Conesa, and J. C. Espín. 2011. Metabolites and tissue distribution of resveratrol in the pig. Molecular Nutrition & Food Research 55 (8):1154–68. doi: 10.1002/mnfr.201100140.
   PubMed Web of Science ®Google Scholar
• Basavaraj, S., and G. V. Betageri. 2014. Improved oral delivery of resveratrol using proliposomal formulation: Investigation of various factors contributing to prolonged absorption of unmetabolized resveratrol. Expert Opinion on Drug Delivery 11 (4):493–503. doi: 10.1517/17425247.2014.878701.
   PubMed Web of Science ®Google Scholar
• Bass, T. M., D. Weinkove, K. Houthoofd, D. Gems, and L. Partridge. 2007. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mechanisms of Ageing and Development 128 (10):546–52. doi: 10.1016/j.mad.2007.07.007.
   PubMed Web of Science ®Google Scholar
• Batista-Jorge, G. C., A. S. Barcala-Jorge, M. F. Silveira, D. F. Lelis, J. M. O. Andrade, A. M. B. de Paula, A. L. S. Guimarães, and S. H. S. Santos. 2020. Oral resveratrol supplementation improves metabolic syndrome features in obese patients submitted to a lifestyle-changing program. Life Sciences 256:117962. doi: 10.1016/j.lfs.2020.117962.
   PubMed Web of Science ®Google Scholar
• Bian, X., W. Wu, L. Yang, L. Lv, Q. Wang, Y. Li, J. Ye, D. Fang, J. Wu, X. Jiang, et al. 2019. Administration of Akkermansia muciniphila ameliorates dextran sulfate sodium-induced ulcerative colitis in mice. Frontiers in Microbiology 10:2259. doi: 10.3389/fmicb.2019.02259.
   PubMed Web of Science ®Google Scholar
• Bird, J. K., D. Raederstorff, P. Weber, and R. E. Steinert. 2017. Cardiovascular and antiobesity effects of resveratrol mediated through the gut microbiota. Advances in Nutrition (Bethesda, MD) 8 (6):839–49. doi: 10.3945/an.117.016568.
   PubMed Web of Science ®Google Scholar
• Bode, L. M., D. Bunzel, M. Huch, G.-S. Cho, D. Ruhland, M. Bunzel, A. Bub, C. M. A. P. Franz, and S. E. Kulling. 2013. In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota. The American Journal of Clinical Nutrition 97 (2):295–309. doi: 10.3945/ajcn.112.049379.
   PubMed Web of Science ®Google Scholar
• Bolte, L. A., A. Vich Vila, F. Imhann, V. Collij, R. Gacesa, V. Peters, C. Wijmenga, A. Kurilshikov, M. J. E. Campmans-Kuijpers, J. Fu, et al. 2021. Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome. Gut 70 (7):1287–98. doi: 10.1136/gutjnl-2020-322670.
   PubMed Web of Science ®Google Scholar
• Brandt, N., D. Kotowska, C. M. Kristensen, J. Olesen, D. O. Lützhøft, J. F. Halling, M. Hansen, W. A. Al-Soud, L. Hansen, P. Kiilerich, et al. 2018. The impact of exercise training and resveratrol supplementation on gut microbiota composition in high‐fat diet fed mice. Physiological Reports 6 (20):e13881. doi: 10.14814/phy2.13881.
   PubMed Web of Science ®Google Scholar
• Brown, V. A., K. R. Patel, M. Viskaduraki, J. A. Crowell, M. Perloff, T. D. Booth, G. Vasilinin, A. Sen, A. M. Schinas, G. Piccirilli, et al. 2010. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: Safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Research 70 (22):9003–11. doi: 10.1158/0008-5472.CAN-10-2364.
   PubMed Web of Science ®Google Scholar
• Burton-Freeman, B. M., and H. D. Sesso. 2014. Whole food versus supplement: Comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors. Advances in Nutrition (Bethesda, MD) 5 (5):457–85. doi: 10.3945/an.114.005231.
   PubMed Web of Science ®Google Scholar
• Buttó, L. F., and D. Haller. 2016. Dysbiosis in intestinal inflammation: Cause or consequence. International Journal of Medical Microbiology: IJMM 306 (5):302–9. doi: 10.1016/j.ijmm.2016.02.010.
   PubMed Web of Science ®Google Scholar
• Cai, T.-T., X.-L. Ye, R.-R. Li, H. Chen, Y.-Y. Wang, H.-J. Yong, M.-L. Pan, W. Lu, Y. Tang, H. Miao, et al. 2020. Resveratrol modulates the gut microbiota and inflammation to protect against diabetic nephropathy in mice. Frontiers in Pharmacology 11:1249. doi: 10.3389/fphar.2020.01249.
   PubMed Web of Science ®Google Scholar
• Campbell, C. L., R. Yu, F. Li, Q. Zhou, D. Chen, C. Qi, Y. Yin, and J. Sun. 2019. Modulation of fat metabolism and gut microbiota by resveratrol on high-fat diet-induced obese mice. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 12:97–107.
   PubMed Web of Science ®Google Scholar
• Cao, Y., H. Liu, N. Qin, X. Ren, B. Zhu, and X. Xia. 2020. Impact of food additives on the composition and function of gut microbiota: A review. Trends in Food Science & Technology 99:295–310. doi: 10.1016/j.tifs.2020.03.006.
   Web of Science ®Google Scholar
• Caussy, C., M. Soni, J. Cui, R. Bettencourt, N. Schork, C.-H. Chen, M. A. Ikhwan, S. Bassirian, S. Cepin, M. P. Gonzalez, Familial NAFLD Cirrhosis Research Consortium, et al. 2017. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. The Journal of Clinical Investigation 127 (7):2697–704. doi: 10.1172/JCI93465.
   PubMed Web of Science ®Google Scholar
• Chakraborty, S., D. Shukla, B. Mishra, and S. Singh. 2009. Lipid–an emerging platform for oral delivery of drugs with poor bioavailability. European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V 73 (1):1–15. doi: 10.1016/j.ejpb.2009.06.001.
   PubMed Web of Science ®Google Scholar
• Chaplin, A., C. Carpene, and J. Mercader. 2018. Resveratrol, metabolic syndrome, and gut microbiota. Nutrients 10 (11):1651. doi: 10.3390/nu10111651.
   PubMed Web of Science ®Google Scholar
• Chen, K., H. Zhao, L. Shu, H. Xing, C. Wang, C. Lu, and G. Song. 2020. Effect of resveratrol on intestinal tight junction proteins and the gut microbiome in high-fat diet-fed insulin resistant mice. International Journal of Food Sciences and Nutrition 71 (8):965–78.
   PubMed Web of Science ®Google Scholar
• Chen, M., P. Hou, M. Zhou, Q. Ren, X. Wang, L. Huang, S. Hui, L. Yi, and M. Mi. 2020. Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system. Clinical Nutrition (Edinburgh, Scotland) 39 (4):1264–75. doi: 10.1016/j.clnu.2019.05.020.
   PubMed Web of Science ®Google Scholar
• Chen, M.-l., L. Yi, Y. Zhang, X. Zhou, L. Ran, J. Yang, J.-d. Zhu, Q.-y. Zhang, and M.-t. Mi. 2016. Resveratrol attenuates trimethylamine-N-oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota. mBio 7 (2):e02210–e02215. doi: 10.1128/mBio.02210-15.
   PubMed Web of Science ®Google Scholar
• Chen, X., H. Li, B. Zhang, andZ. Deng. 2022. The synergistic and antagonistic antioxidant interactions of dietary phytochemical combinations. Critical Reviews in Food Science and Nutrition 62 (20):5658–77. doi: 10.1080/10408398.2021.1888693. PMID: 33612011
   PubMed Web of Science ®Google Scholar
• Chung, J. H., V. Manganiello, and J. R. Dyck. 2012. Resveratrol as a calorie restriction mimetic: Therapeutic implications. Trends in Cell Biology 22 (10):546–54. doi: 10.1016/j.tcb.2012.07.004.
   PubMed Web of Science ®Google Scholar
• Control & Prevention. 2019. Hypertension cascade: hypertension prevalence, treatment and control estimates among US adults aged 18 years and older applying the criteria from the American College of Cardiology and American Heart Association’s 2017 Hypertension Guideline—NHANES 2013–2016. Atlanta, GA: US Department of Health and Human Services.
   Google Scholar
• Cottart, C. H., V. Nivet‐Antoine, and J. L. Beaudeux. 2014. Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans. Molecular Nutrition & Food Research 58 (1):7–21. doi: 10.1002/mnfr.201200589.
   PubMed Web of Science ®Google Scholar
• Cui, X., Y. Jin, A. B. Hofseth, E. Pena, J. Habiger, A. Chumanevich, D. Poudyal, M. Nagarkatti, P. S. Nagarkatti, U. P. Singh, et al. 2010. Resveratrol suppresses colitis and colon cancer associated with colitis. Cancer Prevention Research (Philadelphia, PA) 3 (4):549–59. doi: 10.1158/1940-6207.CAPR-09-0117.
   PubMed Web of Science ®Google Scholar
• Dao, T.-M. A., A. Waget, P. Klopp, M. Serino, C. Vachoux, L. Pechere, D. J. Drucker, S. Champion, S. Barthélemy, Y. Barra, et al. 2011. Resveratrol increases glucose induced GLP-1 secretion in mice: A mechanism which contributes to the glycemic control. PloS One 6 (6):e20700. doi: 10.1371/journal.pone.0020700.
   PubMed Web of Science ®Google Scholar
• David, L. A., C. F. Maurice, R. N. Carmody, D. B. Gootenberg, J. E. Button, B. E. Wolfe, A. V. Ling, A. S. Devlin, Y. Varma, M. A. Fischbach, et al. 2014. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505 (7484):559–63. doi: 10.1038/nature12820.
   PubMed Web of Science ®Google Scholar
• Davinelli, S., G. Scapagnini, F. Marzatico, V. Nobile, N. Ferrara, and G. Corbi. 2017. Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study. Maturitas 96:77–83. doi: 10.1016/j.maturitas.2016.11.016.
   PubMed Web of Science ®Google Scholar
• Derrien, M., M. C. Collado, K. Ben-Amor, S. Salminen, and W. M. de Vos. 2008. The Mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract. Applied and Environmental Microbiology 74 (5):1646–8. doi: 10.1128/AEM.01226-07.
   PubMed Web of Science ®Google Scholar
• DiMarco-Crook, C., and H. Xiao. 2015. Diet-based strategies for cancer chemoprevention: The role of combination regimens using dietary bioactive components. Annual Review of Food Science and Technology 6:505–26. doi: 10.1146/annurev-food-081114-110833.
   PubMed Web of Science ®Google Scholar
• Du, F., R. Huang, D. Lin, Y. Wang, X. Yang, X. Huang, B. Zheng, Z. Chen, Y. Huang, X. Wang, et al. 2021. Resveratrol improves liver steatosis and insulin resistance in non-alcoholic fatty liver disease in association with the gut microbiota. Frontiers in Microbiology 12:611323. doi: 10.3389/fmicb.2021.611323.
   PubMed Web of Science ®Google Scholar
• Duda-Chodak, A., T. Tarko, P. Satora, and P. Sroka. 2015. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: A review. European Journal of Nutrition 54 (3):325–41. doi: 10.1007/s00394-015-0852-y.
   PubMed Web of Science ®Google Scholar
• Earley, H., G. Lennon, Á. Balfe, J. C. Coffey, D. C. Winter, and P. R. O’Connell. 2019. The abundance of Akkermansia muciniphila and its relationship with sulphated colonic mucins in health and ulcerative colitis. Scientific Reports 9 (1):1–9. doi: 10.1038/s41598-019-51878-3.
   PubMedGoogle Scholar
• Eilat-Adar, S., and U. Goldbourt. 2010. Nutritional recommendations for preventing coronary heart disease in women: Evidence concerning whole foods and supplements. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD 20 (6):459–66. doi: 10.1016/j.numecd.2010.01.011.
   PubMed Web of Science ®Google Scholar
• Etxeberria, U., N. Arias, N. Boqué, M. Macarulla, M. Portillo, J. Martínez, and F. Milagro. 2015. Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats. The Journal of Nutritional Biochemistry 26 (6):651–60. doi: 10.1016/j.jnutbio.2015.01.002.
   PubMed Web of Science ®Google Scholar
• Falony, G., S. Vieira-Silva, and J. Raes. 2018. Richness and ecosystem development across faecal snapshots of the gut microbiota. Nature Microbiology 3 (5):526–8. doi: 10.1038/s41564-018-0143-5.
   PubMed Web of Science ®Google Scholar
• Fan, Y., and O. Pedersen. 2021. Gut microbiota in human metabolic health and disease. Nature Reviews Microbiology 19 (1):55–71. doi: 10.1038/s41579-020-0433-9.
   PubMed Web of Science ®Google Scholar
• Fang, X., J. Zhang, J. Zhao, and L. Wang. 2022. Effect of resveratrol combined with donepezil hydrochloride on inflammatory factor level and cognitive function level of patients with Alzheimer’s disease. Journal of Healthcare Engineering 2022:9148650. doi: 10.1155/2022/9148650.
   PubMed Web of Science ®Google Scholar
• Farris, P., M. Yatskayer, N. Chen, Y. Krol, and C. Oresajo. 2014. Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin. Journal of Drugs in Dermatology: JDD 13 (12):1467–72.
   PubMed Web of Science ®Google Scholar
• Fei, Y., S. Zhang, S. Han, B. Qiu, Y. Lu, W. Huang, F. Li, D. Chen, B. Berglund, H. Xiao, et al. 2022. The role of dihydroresveratrol in enhancing the synergistic effect of Ligilactobacillus salivarius Li01 and resveratrol in ameliorating colitis in mice. Research (Washington, DC) 2022:9863845. doi: 10.34133/2022/9863845.
   Google Scholar
• Fogacci, F., G. Tocci, V. Presta, A. Fratter, C. Borghi, and A. F. G. Cicero. 2019. Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials. Critical Reviews in Food Science and Nutrition 59 (10):1605–18. doi: 10.1080/10408398.2017.1422480.
   PubMed Web of Science ®Google Scholar
• Friedman, S. L., B. A. Neuschwander-Tetri, M. Rinella, and A. J. Sanyal. 2018. Mechanisms of NAFLD development and therapeutic strategies. Nature Medicine 24 (7):908–22. doi: 10.1038/s41591-018-0104-9.
   PubMed Web of Science ®Google Scholar
• Fu, Q., Z. Tan, L. Shi, and W. Xun. 2021. Resveratrol attenuates diquat-induced oxidative stress by regulating gut microbiota and metabolome characteristics in piglets. Frontiers in Microbiology:12:695155. doi: 10.3389/fphar.2020.01249.
   PubMed Web of Science ®Google Scholar
• Galiniak, S., D. Aebisher, and D. Bartusik-Aebisher. 2019. Health benefits of resveratrol administration. Acta Biochimica Polonica 66 (1):13–21. doi: 10.18388/abp.2018_2749.
   PubMed Web of Science ®Google Scholar
• Gambini, J., M. Inglés, G. Olaso, R. Lopez-Grueso, V. Bonet-Costa, L. Gimeno-Mallench, C. Mas-Bargues, K. M. Abdelaziz, M. C. Gomez-Cabrera, J. Vina, et al. 2015. Properties of resveratrol: In vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans. Oxidative Medicine and Cellular Longevity 2015:837042. doi: 10.1155/2015/837042.
   PubMed Web of Science ®Google Scholar
• Gan, Z., W. Wei, Y. Li, J. Wu, Y. Zhao, L. Zhang, T. Wang, and X. Zhong. 2019. Curcumin and resveratrol regulate intestinal bacteria and alleviate intestinal inflammation in weaned piglets. Molecules 24 (7):1220. doi: 10.3390/molecules24071220.
   PubMed Web of Science ®Google Scholar
• Gao, Y., Q. Meng, X. Song, Q. Zhao, and B. Shi. 2022. Resveratrol alleviates oxidative stress induced by oxidized soybean oils and improves gut function via changing gut microbiota in weaned piglets. doi: 10.21203/rs.3.rs-1245019/v1.
   Google Scholar
• Geng, J., C. Yang, B. Wang, X. Zhang, T. Hu, Y. Gu, and J. Li. 2018. Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 97:941–7. doi: 10.1016/j.biopha.2017.11.016.
   PubMed Web of Science ®Google Scholar
• Gu, Z.-Y., W.-L. Pei, Y. Zhang, J. Zhu, L. Li, and Z. Zhang. 2021. Akkermansia muciniphila in inflammatory bowel disease and colorectal cancer. Chinese Medical Journal 134 (23):2841–3.
   PubMed Web of Science ®Google Scholar
• Hales, C. M., M. D. Carroll, C. D. Fryar, and C. L. Ogden. 2017. Prevalence of obesity among adults and youth: United States, 2015–2016. NCHS Data Brief No. 288.
   Google Scholar
• Han, Y., S. A. Itenberg, X. Wu, and H. Xiao. 2022. Guidelines for inflammation models in mice for food components. eFood 3 (3):e16. doi: 10.1002/efd2.16.
   Google Scholar
• Hemarajata, P., and J. Versalovic. 2013. Effects of probiotics on gut microbiota: Mechanisms of intestinal immunomodulation and neuromodulation. Therapeutic Advances in Gastroenterology 6 (1):39–51. doi: 10.1177/1756283X12459294.
   PubMed Web of Science ®Google Scholar
• Hijona, E., L. Aguirre, P. Pérez-Matute, M. J. Villanueva-Millán, A. Mosqueda-Solis, M. Hasnaoui, F. Nepveu, J. M. Senard, L. Bujanda, L. Aldámiz-Echevarría, et al. 2016. Limited beneficial effects of piceatannol supplementation on obesity complications in the obese Zucker rat: Gut microbiota, metabolic, endocrine, and cardiac aspects. Journal of Physiology and Biochemistry 72 (3):567–82. doi: 10.1007/s13105-015-0464-2.
   PubMed Web of Science ®Google Scholar
• Hoseini, A., G. Namazi, A. Farrokhian, Z. Reiner, E. Aghadavod, F. Bahmani, and Z. Asemi. 2019. The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease. Food & Function 10 (9):6042–51. doi: 10.1039/c9fo01075k.
   PubMed Web of Science ®Google Scholar
• Hussain, S. A., B. H. Marouf, Z. S. Ali, and R. S. Ahmmad. 2018. Efficacy and safety of co-administration of resveratrol with meloxicam in patients with knee osteoarthritis: A pilot interventional study. Clinical Interventions in Aging 13:1621–30. doi: 10.2147/CIA.S172758.
   PubMed Web of Science ®Google Scholar
• JacobsJr, D. R., M. D. Gross, and L. C. Tapsell. 2009. Food synergy: An operational concept for understanding nutrition. The American Journal of Clinical Nutrition 89 (5):1543S–8S. doi: 10.3945/ajcn.2009.26736B.
   PubMed Web of Science ®Google Scholar
• Jung, M.-J., J. Lee, N.-R. Shin, M.-S. Kim, D.-W. Hyun, J.-H. Yun, P. S. Kim, T. W. Whon, and J.-W. Bae. 2016. Chronic repression of mTOR complex 2 induces changes in the gut microbiota of diet-induced obese mice. Scientific Reports 6 (1):30887–10. doi: 10.1038/srep30887.
   PubMedGoogle Scholar
• Kong, L.-C., J. Tap, J. Aron-Wisnewsky, V. Pelloux, A. Basdevant, J.-L. Bouillot, J.-D. Zucker, J. Doré, and K. Clément. 2013. Gut microbiota after gastric bypass in human obesity: Increased richness and associations of bacterial genera with adipose tissue genes. The American Journal of Clinical Nutrition 98 (1):16–24. doi: 10.3945/ajcn.113.058743.
   PubMed Web of Science ®Google Scholar
• Larrosa, M., M. J. Yañéz-Gascón, M. V. Selma, A. González-Sarrías, S. Toti, J. J. Cerón, F. Tomás-Barberán, P. Dolara, and J. C. Espín. 2009. Effect of a low dose of dietary resveratrol on colon microbiota, inflammation and tissue damage in a DSS-induced colitis rat model. Journal of Agricultural and Food Chemistry 57 (6):2211–20. doi: 10.1021/jf803638d.
   PubMed Web of Science ®Google Scholar
• Li, D. Y., and W. Tang. 2017. Gut microbiota and atherosclerosis. Current Atherosclerosis Reports 19 (10):1–12. doi: 10.1007/s11883-017-0675-9.
   PubMed Web of Science ®Google Scholar
• Li, F., Y. Han, X. Cai, M. Gu, J. Sun, C. Qi, T. Goulette, M. Song, Z. Li, and H. Xiao. 2020. Dietary resveratrol attenuated colitis and modulated gut microbiota in dextran sulfate sodium-treated mice. Food & Function 11 (1):1063–73.
   PubMed Web of Science ®Google Scholar
• Li, F., Y. Han, X. Wu, X. Cao, Z. Gao, Y. Sun, M. Wang, and H. Xiao. 2022. Gut microbiota-derived resveratrol metabolites, dihydroresveratrol and lunularin, significantly contribute to the biological activities of resveratrol. Frontiers in Nutrition 9:22–31. doi: 10.3389/fnut.2022.912591.
   Web of Science ®Google Scholar
• Li, M., P. Li, R. Tang, and H. Lu. 2022. Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways. Food Science and Human Wellness 11 (1):22–31. doi: 10.1016/j.fshw.2021.07.003.
   Google Scholar
• Libertucci, J., and V. B. Young. 2019. The role of the microbiota in infectious diseases. Nature Microbiology 4 (1):35–45. doi: 10.1038/s41564-018-0278-4.
   PubMed Web of Science ®Google Scholar
• Liu, R. H. 2003. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. The American Journal of Clinical Nutrition 78 (3 Suppl):517S–20S. doi: 10.1093/ajcn/78.3.517S.
   PubMed Web of Science ®Google Scholar
• Liu, Y., and M. Dai. 2020. Trimethylamine N-oxide generated by the gut microbiota is associated with vascular inflammation: New insights into atherosclerosis. Mediators of Inflammation 2020:4634172. doi: 10.1155/2020/4634172.
   PubMed Web of Science ®Google Scholar
• Loomba, R., N. Schork, C.-H. Chen, R. Bettencourt, A. Bhatt, B. Ang, P. Nguyen, C. Hernandez, L. Richards, J. Salotti, Genetics of NAFLD in Twins Consortium, et al. 2015. Heritability of hepatic fibrosis and steatosis based on a prospective twin study. Gastroenterology 149 (7):1784–93. doi: 10.1053/j.gastro.2015.08.011.
   PubMed Web of Science ®Google Scholar
• Man, A. W. C., H. Li, and N. Xia. 2020. Resveratrol and the interaction between gut microbiota and arterial remodelling. Nutrients 12 (1):119. doi: 10.3390/nu12010119.
   PubMed Web of Science ®Google Scholar
• Marchesi, J. R., D. H. Adams, F. Fava, G. D. A. Hermes, G. M. Hirschfield, G. Hold, M. N. Quraishi, J. Kinross, H. Smidt, K. M. Tuohy, et al. 2016. The gut microbiota and host health: A new clinical frontier. Gut 65 (2):330–9. doi: 10.1136/gutjnl-2015-309990.
   PubMed Web of Science ®Google Scholar
• Matsuoka, K., and T. Kanai. 2015. The gut microbiota and inflammatory bowel disease. Seminars in Immunopathology 37 (1):47–55. doi: 10.1007/s00281-014-0454-4.
   PubMed Web of Science ®Google Scholar
• McAnulty, L. S., L. E. Miller, P. A. Hosick, A. C. Utter, J. C. Quindry, and S. R. McAnulty. 2013. Effect of resveratrol and quercetin supplementation on redox status and inflammation after exercise. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition et Metabolisme 38 (7):760–5. doi: 10.1139/apnm-2012-0455.
   PubMed Web of Science ®Google Scholar
• Meng, Q., S. Sun, Z. Luo, B. Shi, A. Shan, and B. Cheng. 2019. Maternal dietary resveratrol alleviates weaning-associated diarrhea and intestinal inflammation in pig offspring by changing intestinal gene expression and microbiota. Food & Function 10 (9):5626–43. doi: 10.1039/c9fo00637k.
   PubMed Web of Science ®Google Scholar
• Meng, X., J. Zhou, C.-N. Zhao, R.-Y. Gan, and H.-B. Li. 2020. Health benefits and molecular mechanisms of resveratrol: A narrative review. Foods 9 (3):340. doi: 10.3390/foods9030340.
   PubMed Web of Science ®Google Scholar
• Militaru, C., I. Donoiu, A. Craciun, I. D. Scorei, A. M. Bulearca, and R. I. Scorei. 2013. Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: Effects on lipid profiles, inflammation markers, and quality of life. Nutrition (Burbank, Los Angeles County, CA) 29 (1):178–83. doi: 10.1016/j.nut.2012.07.006.
   PubMed Web of Science ®Google Scholar
• Miraglia Del Giudice, M., N. Maiello, C. Capristo, E. Alterio, M. Capasso, L. Perrone, and G. Ciprandi. 2014. Resveratrol plus carboxymethyl-β-glucan reduces nasal symptoms in children with pollen-induced allergic rhinitis. Current Medical Research and Opinion 30 (10):1931–5. doi: 10.1185/03007995.2014.938731.
   PubMed Web of Science ®Google Scholar
• Montagne, L., G. Boudry, C. Favier, I. Le Huërou-Luron, J.-P. Lalles, and B. Seve. 2007. Main intestinal markers associated with the changes in gut architecture and function in piglets after weaning. The British Journal of Nutrition 97 (1):45–57. doi: 10.1017/S000711450720580X.
   PubMed Web of Science ®Google Scholar
• Most, J., G. H. Goossens, J. W. Jocken, and E. E. Blaak. 2014. Short-term supplementation with a specific combination of dietary polyphenols increases energy expenditure and alters substrate metabolism in overweight subjects. International Journal of Obesity (2005) 38 (5):698–706. doi: 10.1038/ijo.2013.231.
   PubMed Web of Science ®Google Scholar
• Most, J., I. Warnke, M. V. Boekschoten, J. W. E. Jocken, P. de Groot, A. Friedel, I. Bendik, G. H. Goossens, and E. E. Blaak. 2018. The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans. Adipocyte 7 (3):190–6. doi: 10.1080/21623945.2018.1469942.
   PubMed Web of Science ®Google Scholar
• Most, J., J. Penders, M. Lucchesi, G. Goossens, and E. Blaak. 2017. Gut microbiota composition in relation to the metabolic response to 12-week combined polyphenol supplementation in overweight men and women. European Journal of Clinical Nutrition 71 (9):1040–5. doi: 10.1038/ejcn.2017.89.
   PubMed Web of Science ®Google Scholar
• Most, J., S. Timmers, I. Warnke, J. W. Jocken, M. van Boekschoten, P. de Groot, I. Bendik, P. Schrauwen, G. H. Goossens, and E. E. Blaak. 2016. Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: A randomized controlled trial. The American Journal of Clinical Nutrition 104 (1):215–27. doi: 10.3945/ajcn.115.122937.
   PubMed Web of Science ®Google Scholar
• Mozos, I., C. Malainer, J. Horbańczuk, C. Gug, D. Stoian, C. T. Luca, and A. G. Atanasov. 2017. Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases. Frontiers in Immunology 8:1058. doi: 10.3389/fimmu.2017.01058.
   PubMed Web of Science ®Google Scholar
• Mutoh, M., M. Takahashi, K. Fukuda, Y. Matsushima-Hibiya, H. Mutoh, T. Sugimura, and K. Wakabayashi. 2000. Suppression of cyclooxygenase-2 promoterdependent transcriptional activity in colon cancer cells by chemopreventiveagents with a resorcin-type structure. Carcinogenesis 21 (5):959–63. doi: 10.1093/carcin/21.5.959.
   PubMed Web of Science ®Google Scholar
• Nunes, S., F. Danesi, D. Del Rio, and P. Silva. 2018. Resveratrol and inflammatory bowel disease: The evidence so far. Nutrition Research Reviews 31 (1):85–97. doi: 10.1017/S095442241700021X.
   PubMed Web of Science ®Google Scholar
• Oh, S. Y., K.-A. Cho, J. L. Kang, K. H. Kim, and S.-Y. Woo. 2014. Comparison of experimental mouse models of inflammatory bowel disease. International Journal of Molecular Medicine 33 (2):333–40. doi: 10.3892/ijmm.2013.1569.
   PubMed Web of Science ®Google Scholar
• Ortiz, B. O. M., A. R. F. Preciado, J. R. Emiliano, S. M. Garza, E. R. Rodríguez, and L. A. de Alba Macías. 2019. Recovery of bone and muscle mass in patients with chronic kidney disease and iron overload on hemodialysis and taking combined supplementation with curcumin and resveratrol. Clinical Interventions in Aging 14:2055–62.
   PubMed Web of Science ®Google Scholar
• Peng, R. M., G. R. Lin, Y. Ting, and J. Y. Hu. 2018. Oral delivery system enhanced the bioavailability of stilbenes: Resveratrol and pterostilbene. BioFactors (Oxford, England) 44 (1):5–15. doi: 10.1002/biof.1405.
   PubMed Web of Science ®Google Scholar
• Pickard, J. M., M. Y. Zeng, R. Caruso, and G. Núñez. 2017. Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease. Immunological Reviews 279 (1):70–89. doi: 10.1111/imr.12567.
   PubMed Web of Science ®Google Scholar
• Ponticelli, C., and R. J. Glassock. 2019. Prevention of complications from use of conventional immunosuppressants: A critical review. Journal of Nephrology 32 (6):851–70. doi: 10.1007/s40620-019-00602-5.
   PubMed Web of Science ®Google Scholar
• Qiao, Y., J. Sun, S. Xia, X. Tang, Y. Shi, and G. Le. 2014. Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity. Food & Function 5 (6):1241–9. doi: 10.1039/c3fo60630a.
   PubMed Web of Science ®Google Scholar
• Qiu, Y., J. Yang, L. Wang, X. Yang, K. Gao, C. Zhu, and Z. Jiang. 2021. Dietary resveratrol attenuation of intestinal inflammation and oxidative damage is linked to the alteration of gut microbiota and butyrate in piglets challenged with deoxynivalenol. Journal of Animal Science and Biotechnology 12 (1):1–17. doi: 10.1186/s40104-021-00596-w.
   PubMed Web of Science ®Google Scholar
• Rabbani, N., M. Xue, M. O. Weickert, and P. J. Thornalley. 2021. Reversal of insulin resistance in overweight and obese subjects by trans-resveratrol and hesperetin combination—link to dysglycemia, blood pressure, dyslipidemia, and low-grade inflammation. Nutrients 13 (7):2374. doi: 10.3390/nu13072374.
   PubMed Web of Science ®Google Scholar
• Rapsomaniki, E., A. Timmis, J. George, M. Pujades-Rodriguez, A. D. Shah, S. Denaxas, I. R. White, M. J. Caulfield, J. E. Deanfield, L. Smeeth, et al. 2014. Blood pressure and incidence of twelve cardiovascular diseases: Lifetime risks, healthy life-years lost, and age-specific associations in 1· 25 million people. The Lancet 383 (9932):1899–911. doi: 10.1016/S0140-6736(14)60685-1.
   PubMed Web of Science ®Google Scholar
• Roth, G. A., C. Johnson, A. Abajobir, F. Abd-Allah, S. F. Abera, G. Abyu, M. Ahmed, B. Aksut, T. Alam, K. Alam, et al. 2017. Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. Journal of the American College of Cardiology 70 (1):1–25. doi: 10.1016/j.jacc.2017.04.052.
   PubMed Web of Science ®Google Scholar
• Samaei, A., K. Moradi, S. Bagheri, A. Ashraf-Ganjouei, R. Alikhani, S. B. Mousavi, F. Rezaei, and S. Akhondzadeh. 2020. Resveratrol adjunct therapy for negative symptoms in patients with stable Schizophrenia: A double-blind, randomized placebo-controlled trial. The International Journal of Neuropsychopharmacology 23 (12):775–82. doi: 10.1093/ijnp/pyaa006.
   PubMed Web of Science ®Google Scholar
• Sartor, R. B., and G. D. Wu. 2017. Roles for intestinal bacteria, viruses, and fungi in pathogenesis of inflammatory bowel diseases and therapeutic approaches. Gastroenterology 152 (2):327–39.e324. doi: 10.1053/j.gastro.2016.10.012.
   PubMed Web of Science ®Google Scholar
• Sawa, S., M. Lochner, N. Satoh-Takayama, S. Dulauroy, M. Bérard, M. Kleinschek, M. D. Cua, J. P. Di Santo, and G. Eberl. 2011. RORγt + innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nature Immunology 12 (4):320–6.
   PubMed Web of Science ®Google Scholar
• Shaito, A., A. M. Posadino, N. Younes, H. Hasan, S. Halabi, D. Alhababi, A. Al-Mohannadi, W. M. Abdel-Rahman, A. H. Eid, G. K. Nasrallah, et al. 2020. Potential adverse effects of resveratrol: A literature review. International Journal of Molecular Sciences 21 (6):2084. doi: 10.3390/ijms21062084.
   PubMed Web of Science ®Google Scholar
• Shen, L., and H.-F. Ji. 2018. Reciprocal interactions between resveratrol and gut microbiota deepen our understanding of molecular mechanisms underlying its health benefits. Trends in Food Science & Technology 81:232–6. doi: 10.1016/j.tifs.2018.09.026.
   Web of Science ®Google Scholar
• Shi, Y., J. Zhou, B. Jiang, and M. Miao. 2017. Resveratrol and inflammatory bowel disease. Annals of the New York Academy of Sciences 1403 (1):38–47.
   PubMed Web of Science ®Google Scholar
• Song, X., L. Liu, S. Peng, T. Liu, Y. Chen, R. Jia, Y. Zou, L. Li, X. Zhao, X. Liang, et al. 2022. Resveratrol regulates intestinal barrier function in cyclophosphamide‐induced immunosuppressed mice. Journal of the Science of Food and Agriculture 102 (3):1205–15. doi: 10.1002/jsfa.11458.
   PubMed Web of Science ®Google Scholar
• Stojanov, S., A. Berlec, and B. Štrukelj. 2020. The influence of probiotics on the Firmicutes/Bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease. Microorganisms 8 (11):1715. doi: 10.3390/microorganisms8111715.
   PubMed Web of Science ®Google Scholar
• Sung, M. M., N. J. Byrne, I. M. Robertson, T. T. Kim, V. Samokhvalov, J. Levasseur, C.-L. Soltys, D. Fung, N. Tyreman, E. Denou, et al. 2017. Resveratrol improves exercise performance and skeletal muscle oxidative capacity in heart failure. American Journal of Physiology. Heart and Circulatory Physiology 312 (4):H842–H853. doi: 10.1152/ajpheart.00455.2016.
   PubMed Web of Science ®Google Scholar
• Sung, M. M., T. T. Kim, E. Denou, C.-L M. Soltys, S. M. Hamza, N. J. Byrne, G. Masson, H. Park, D. S. Wishart, K. L. Madsen, et al. 2017. Improved glucose homeostasis in obese mice treated with resveratrol is associated with alterations in the gut microbiome. Diabetes 66 (2):418–25. doi: 10.2337/db16-0680.
   PubMed Web of Science ®Google Scholar
• Tain, Y. L., W. C. Lee, K. L. Wu, S. Leu, and J. Y. Chan. 2018. Resveratrol prevents the development of hypertension programmed by maternal plus post‐weaning high‐fructose consumption through modulation of oxidative stress, nutrient‐sensing signals, and gut microbiota. Molecular Nutrition & Food Research 62 (15):1800066. doi: 10.1002/mnfr.201800066.
   Web of Science ®Google Scholar
• Talebi, M., M. Talebi, T. Farkhondeh, and S. Samarghandian. 2022. Therapeutic effects of resveratrol in inflammatory bowel diseases: Shedding light on the role of cellular and molecular pathways. Revista Brasileira de Farmacognosia 32:160–73. doi: 10.1007/s43450-022-00247-9.
   Google Scholar
• Tan, J., C. McKenzie, M. Potamitis, A. N. Thorburn, C. R. Mackay, and L. Macia. 2014. The role of short-chain fatty acids in health and disease. Advances in Immunology 121:91–119. doi: 10.1016/B978-0-12-800100-4.00003-9.
   PubMed Web of Science ®Google Scholar
• Thaung Zaw, J. J., P. R. C. Howe, and R. H. X. Wong. 2020. Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: Findings from a 24-month randomized, controlled, crossover trial. Menopause (New York, NY) 28 (1):40–9. doi: 10.1097/GME.0000000000001643.
   PubMed Web of Science ®Google Scholar
• Tindall, A. M., K. S. Petersen, and P. M. Kris-Etherton. 2018. Dietary patterns affect the gut microbiome-the link to risk of cardiometabolic diseases. The Journal of Nutrition 148 (9):1402–7. doi: 10.1093/jn/nxy141.
   PubMed Web of Science ®Google Scholar
• Tung, Y.-C., Y.-H. Lin, H.-J. Chen, S.-C. Chou, A.-C. Cheng, N. Kalyanam, C.-T. Ho, and M.-H. Pan. 2016. Piceatannol exerts anti-obesity effects in C57BL/6 mice through modulating adipogenic proteins and gut microbiota. Molecules 21 (11):1419. doi: 10.3390/molecules21111419.
   PubMed Web of Science ®Google Scholar
• Turnbaugh, P. J., and J. I. Gordon. 2009. The core gut microbiome, energy balance and obesity. The Journal of Physiology 587 (Pt 17):4153–8.
   PubMed Web of Science ®Google Scholar
• Ullman, T. A., and S. H. Itzkowitz. 2011. Intestinal inflammation and cancer. Gastroenterology 140 (6):1807–16.e1801. doi: 10.1053/j.gastro.2011.01.057.
   PubMed Web of Science ®Google Scholar
• Varricchio, A. M., M. Capasso, A. Della Volpe, L. Malafronte, N. Mansi, A. Varricchio, and G. Ciprandi. 2014. Resveratrol plus carboxymethyl-β-glucan in children with recurrent respiratory infections: A preliminary and real-life experience. Italian Journal of Pediatrics 40 (1):1–6. doi: 10.1186/s13052-014-0093-3.
   PubMedGoogle Scholar
• Wang, P., J. Wang, D. Li, W. Ke, F. Chen, and X. Hu. 2020. Targeting the gut microbiota with resveratrol: A demonstration of novel evidence for the management of hepatic steatosis. The Journal of Nutritional Biochemistry 81:108363.
   PubMed Web of Science ®Google Scholar
• Wang, Z., A. B. Roberts, J. A. Buffa, B. S. Levison, W. Zhu, E. Org, X. Gu, Y. Huang, M. Zamanian-Daryoush, M. K. Culley, et al. 2015. Non-lethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis. Cell 163 (7):1585–95. doi: 10.1016/j.cell.2015.11.055.
   PubMed Web of Science ®Google Scholar
• Wu, S.-X., R.-G. Xiong, S.-Y. Huang, D.-D. Zhou, A. Saimaiti, C.-N. Zhao, A. Shang, Y.-J. Zhang, R.-Y. Gan, and H.-B. Li. 2022. Effects and mechanisms of resveratrol for prevention and management of cancers: An updated review. Critical Reviews in Food Science and Nutrition:1–19. doi: 10.1080/10408398.2022.2101428.
   Web of Science ®Google Scholar
• Yao, M., Y. Fei, S. Zhang, B. Qiu, L. Zhu, F. Li, B. Berglund, H. Xiao, and L. Li. 2022. Gut microbiota composition in relation to the metabolism of oral administrated resveratrol. Nutrients 14 (5):1013. doi: 10.3390/nu14051013.
   PubMed Web of Science ®Google Scholar
• Younossi, Z., Q. M. Anstee, M. Marietti, T. Hardy, L. Henry, M. Eslam, J. George, and E. Bugianesi. 2018. Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention. Nature Reviews. Gastroenterology & Hepatology 15 (1):11–20. doi: 10.1038/nrgastro.2017.109.
   PubMed Web of Science ®Google Scholar
• Zhang, B., Y. Xu, H. Lv, W. Pang, J. Wang, H. Ma, and S. Wang. 2021. Intestinal pharmacokinetics of resveratrol and regulatory effects of resveratrol metabolites on gut barrier and gut microbiota. Food Chemistry 357:129532. doi: 10.1016/j.foodchem.2021.129532.
   PubMed Web of Science ®Google Scholar
• Zhang, Y.-J., S. Li, R.-Y. Gan, T. Zhou, D.-P. Xu, and H.-B. Li. 2015. Impacts of gut bacteria on human health and diseases. International Journal of Molecular Sciences 16 (4):7493–519. doi: 10.3390/ijms16047493.
   PubMed Web of Science ®Google Scholar
• Zhao, L., Q. Zhang, W. Ma, F. Tian, H. Shen, and M. Zhou. 2017. A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota. Food & Function 8 (12):4644–56. doi: 10.1039/c7fo01383c.
   PubMed Web of Science ®Google Scholar
• Zheng, Z., Y. Chen, J. Huang, H. Deng, X. Tang, and X. J. Wang. 2019. Mkp-1 is required for chemopreventive activity of butylated hydroxyanisole and resveratrol against colitis-associated colon tumorigenesis. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 127:72–80.
   PubMed Web of Science ®Google Scholar
• Zhu, F., J. Zheng, F. Xu, Y. Xi, J. Chen, and X. Xu. 2021. Resveratrol alleviates dextran sulfate sodium-induced acute ulcerative colitis in mice by mediating PI3K/Akt/VEGFA pathway. Frontiers in Pharmacology 12:693982. doi: 10.3389/fphar.2021.693982.
   PubMed Web of Science ®Google Scholar
• Zhuang, Y., H. Huang, S. Liu, F. Liu, Q. Tu, Y. Yin, and S. He. 2021. Resveratrol improves growth performance, intestinal morphology, and microbiota composition and metabolism in mice. Frontiers in Microbiology 12:726878. doi: 10.3389/fmicb.2021.726878.
   PubMed Web of Science ®Google Scholar