The Design and Synthesis of Sulfur Containing Bisphosphonic Acids for the Treatment of Arthritis

Abstract

The sulfur containing bisphosphonic acids have been examined as a chondroprotective therapy for the treatment of arthritis. Several compounds have demonstrated both in vitro and in vivo activity. The newly synthesized compounds all contain a latent or a free thiol group which may bind to the zinc atom in the active site of the matrix metalloproteases. The in vivo activity of some of these bisphosphonic acids in the rat adjuvant model of arthritis is also discussed.

Keywords::

• bisphosphonate
• arthritis
• antiinflammatory