References
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- Inhibition of the MMPs by bisphosphonates has previously been disclosed. See: Teronen O. Kontinnen Y. T. Lindqvist C. Salo T. Lauhio A. Ding Y. Santavirta S. Sorsa T. J. Dent. Res. , 76 , 1529 ( 1997 ).
- Inhibition of MMPs may provide a therapeutic benefit for the treatment of arthritis. See: Cawston T.E. Pharmacol. Ther. 70 , 163 ( 1996 ).
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- No dose-ranging studies were performed with the thio-bisphosphonic acids, therefore the lowest effective dose for these compounds has not been determined .