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Original Articles

Characteristics and risk factors of infections following CD28-based CD19 CAR-T cells

, , , , , , , , ORCID Icon & show all
Pages 1692-1701 | Received 19 Sep 2020, Accepted 17 Jan 2021, Published online: 10 Feb 2021
 

Abstract

CAR T-cells are approved for the treatment of relapsed and refractory leukemia and lymphoma. Here, we studied the infectious complications in 88 patients treated with CD28-based CD19 CAR T-cells. Overall, 36 infections were documented in 24 patients within the first month after CAR T-cell infusion: Six events of bacteremia, sixteen focal bacterial infections, and fourteen systemic or localized viral infections. Seven patients had nine infectious episodes beyond the first 30 days of follow-up, including three events of bacteremia, three focal bacterial, two viral and one fungal infection. The presence of neutropenia, neutropenic fever and lack of response to treatment were associated with a higher rate of infections. Children had less severe infections than adults. In a multivariate analysis lack of response to treatment was the only significant risk factor. Overall, the incidence of bacterial infections following CAR T-cells is modest especially in children and in patients responding to therapy.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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