An insertion-deletion polymorphism in angiotensin-converting enzyme is associated with a reduced risk of preeclampsia: an evidence-based meta-analysis from 44 studies

ABSTRACT

Objective

An updated meta-analysis was performed to evaluate the relationship between an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme (ACE) and preeclampsia (PE) risk.

Methods

Pubmed, OVID and China National Knowledge Infrastructure databases were searched. Pooled odds ratios with 95% confidence intervals were calculated using fixed-effects or random-effects model.

Results

ACE I/D

polymorphism decreased the risk of PE in overall analysis. Subgroup analysis revealed a significantly lower risk of PE with ACE I/D polymorphism in Asians, Caucasians. The decreased risk was also found in severe PE and early-onset PE.

Conclusion

ACE

I/D polymorphism may protect against the development of PE.

KEYWORDS:

• Angiotensin-converting enzyme
• polymorphism
• preeclampsia
• meta-analysis

Author contributions

Huang T and Yan Y collected data and performed statistical analysis. Li J and Chen H helped to collect data. Chen Z designed and wrote the manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by a grant from Science and Technology Commission Joint Medical Research Project of Chongqing City (No.2019MSXM039).