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Research Article

An insertion-deletion polymorphism in angiotensin-converting enzyme is associated with a reduced risk of preeclampsia: an evidence-based meta-analysis from 44 studies

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Pages 336-347 | Received 10 Mar 2020, Accepted 11 May 2020, Published online: 02 Jun 2020

References

  • Poon LC, Shennan A, Hyett JA, et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: a pragmatic guide for first-trimester screening and prevention. Int J Gynaecol Obstet. 2019;145 Suppl 1(Suppl 1):1–33. PubMed PMID: 31111484; eng.
  • Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science. 2005 Jun 10;308(5728):1592–1594. PubMed PMID: 15947178.
  • Al-Jameil N, Aziz Khan F, Fareed Khan M, et al. A brief overview of preeclampsia. J Clin Med Res. 2014 Feb;6(1):1–7. PubMed PMID: 24400024; PubMed Central PMCID: PMC3881982.
  • Roberts JM Endothelial dysfunction in preeclampsia. Semin Reprod Endocrinol. 1998;16( 1):5–15. . PubMed PMID: 9654603.
  • DiFederico E, Genbacev O, Fisher SJ. Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am J Pathol. 1999 Jul;155(1):293–301. PubMed PMID: 10393861; PubMed Central PMCID: PMC1866652.
  • Irani RA, Xia Y. The functional role of the renin-angiotensin system in pregnancy and preeclampsia. Placenta. 2008 Sep;29(9):763–771. PubMed PMID: 18687466; PubMed Central PMCID: PMC2614866.
  • Shah DM. Role of the renin-angiotensin system in the pathogenesis of preeclampsia. Am J Physiol Renal Physiol. 2005 Apr;288(4):F614–25. PubMed PMID: 15753325.
  • Shah DM. The role of RAS in the pathogenesis of preeclampsia. Curr Hypertens Rep. 2006 May;8(2):144–152. PubMed PMID: 16672148.
  • Uddin MN, Agunanne E, Horvat D, et al. Alterations in the renin-angiotensin system in a rat model of human preeclampsia. Am J Nephrol. 2010;31(2):171–177. PubMed PMID: 20016143.
  • Ehlers MR, Riordan JF. Angiotensin-converting enzyme: new concepts concerning its biological role. Biochemistry. 1989 Jun 27;28(13):5311–5318. PubMed PMID: 2476171.
  • Talledo OE. Renin-angiotensin system in normal and toxemic pregnancies. II. Inactivation of angiotensin in normal pregnancy. Am J Obstet Gynecol. 1967 Feb 15;97(4):571–572. PubMed PMID: 4289194.
  • Chinn RH, Dusterdieck G. The response of blood pressure to infusion of angiotensin II: relation to plasma concentrations of renin and angiotensin II. Clin Sci. 1972 Apr;42(4):489–504. PubMed PMID: 4336431.
  • Rasmussen AB, Pedersen EB, Romer FK, et al. The influence of normotensive pregnancy and pre-eclampsia on angiotensin-converting enzyme. Acta Obstet Gynecol Scand. 1983;62(4):341–344. PubMed PMID: 6314730.
  • Rigat B, Hubert C, Alhenc-Gelas F, et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990 Oct;86(4):1343–1346. PubMed PMID: 1976655; PubMed Central PMCID: PMC296868.
  • Tiret L, Rigat B, Visvikis S, et al. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet. 1992 Jul;51(1):197–205. PubMed PMID: 1319114; PubMed Central PMCID: PMC1682892.
  • Medica I, Kastrin A, Peterlin B. Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2007 Apr;131(2):115–126. PubMed PMID: 17112651.
  • Zhu M, Zhang J, Nie S, et al. Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis. J Assist Reprod Genet. 2012 Sep;29(9):921–932. PubMed PMID: 22644634; PubMed Central PMCID: PMC3463655.
  • Zhong WG, Wang Y, Zhu H, et al. Meta analysis of angiotensin-converting enzyme I/D polymorphism as a risk factor for preeclampsia in Chinese women. Genet Mol Res: GMR. 2012 Aug 13;11(3):2268–2276. PubMed PMID: 22653650.
  • Chen Z, Xu F, Wei Y, et al. Angiotensin converting enzyme insertion/deletion polymorphism and risk of pregnancy hypertensive disorders: a meta-analysis. J Renin Angiotensin Aldosterone Sys. 2012 Mar;13(1):184–195. PubMed PMID: 22086840.
  • Buurma AJ, Turner RJ, Driessen JHM, et al. Genetic variants in pre-eclampsia: A meta-analysis. Hum Reprod Update. 2013;19(3):289–303. English.
  • Shaik AP, Sultana A, Bammidi VK, et al. A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women. J Obstet Gynaecol. 2011 Oct;31(7):603–607. PubMed PMID: 21973132.
  • Staines-Urias E, Paez MC, Doyle P, et al. Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis. Int J Epidemiol. 2012 Dec;41(6):1764–1775. PubMed PMID: 23132613.
  • Abedin Do A, Esmaeilzadeh E, Amin-Beidokhti M, et al. ACE gene rs4343 polymorphism elevates the risk of preeclampsia in pregnant women. J Hum Hypertens. 2018 Dec;32(12):825–830. 10.1038/s41371-018-0096-4. PubMed PMID: 30127488.
  • Aung M, Konoshita T, Moodley J, et al. Association of gene polymorphisms of aldosterone synthase and angiotensin converting enzyme in pre-eclamptic South African Black women. Pregnancy Hypertens. 2018 Jan;11:38–43. PubMed PMID: 29523271.
  • Cristina Dos Santos Lopes A, Perucci LO, Gontijo Evangelista FC, et al. Association among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women. Mol Cell Probes. 2019 Jun;45:43–47. PubMed PMID: 31028794.
  • Gonzalez-Garrido JA, Garcia-Sanchez JR, Tovar-Rodriguez JM, et al. Preeclampsia is associated with ACE I/D polymorphism, obesity and oxidative damage in Mexican women. Pregnancy Hypertens. 2017 Oct;10:22–27. PubMed PMID: 29153683.
  • Jahan P, Deepthi G, Komaravalli PL, et al. A study on the role of HLA-G 14bp and ACE IN/DEL polymorphisms in pre-eclamptic South Indian women. Pregnancy Hypertens. 2014 Apr;4(2):164–169. PubMed PMID: 26104422.
  • Ma L, Fan P, Liu X-H, et al. Interaction between GNB3 C825T and ACE I/D polymorphisms in pre-eclampsia. Sichuan Da Xue Xue Bao Yi Xue Ban. 2015;46(1):118–122. PubMed PMID: 25807809; chi.
  • Procopciuc LM, Nemeti G, Buzdugan E, et al. Renin-angiotensin system gene variants and risk of early- and late-onset preeclampsia: A single center case-control study. Pregnancy Hypertens. 2019 Oct;18:1–8. PubMed PMID: 31442828.
  • Reshetnikov EA, Yakunchenko TI, Aristova IK, et al. Associations of insertion-deletion polymorphism of angiotensin-converting enzyme with the risk of preeclampsia development among pregnant women in central Russia. Asian J Pharm. 2017;11(3 Supplement):S635–S639. English.
  • Shaheen G, Sajid S, Razak S, et al. Role of ACE I/D polymorphism in pathological assessment of preeclampsia in Pakistan. Mol Genet Genomic Med. 2019 Jul;7(7):e00799. PubMed PMID: 31173490; PubMed Central PMCID: PMC6625086.
  • Timokhina EV, Strizhakov AN, Ignatko IV, et al. Genetic aspects of preeclampsia: the role of polymorphisms in the genes of the renin-angiotensin system. Biochem Biokhimiia. 2019 Feb;84(2):181–186. PubMed PMID: 31216977.
  • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002 Jun 15;21(11):1539–1558. PubMed PMID: 12111919; eng.
  • Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. PubMed PMID: 13655060; eng.
  • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177–188. 0197-2456(86)90046-2 [pii]. PubMed PMID: 3802833; eng.
  • Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997 Sep 13;315(7109):629–634. PubMed PMID: 9310563; PubMed Central PMCID: PMC2127453. eng.
  • Griendling KK, Murphy TJ, Alexander RW. Molecular biology of the renin-angiotensin system. Circulation. 1993 Jun;87(6):1816–1828. PubMed PMID: 8389259.
  • Bereketoglu C, Kasap M, Pazarbasi A. Studies on an evidence-based meta-analysis and genotype distributions in Turkish preeclampsia patients. J Pregnancy. 2012;2012:108206. PubMed PMID: 22545216; PubMed Central PMCID: PMC3321565.
  • Mando C, Antonazzo P, Tabano S, et al. Angiotensin-converting enzyme and adducin-1 polymorphisms in women with preeclampsia and gestational hypertension. Reprod Sci. 2009 Sep;16(9):819–826. PubMed PMID: 19443911.
  • Esplin MS, Fausett MB, Fraser A, et al. Paternal and maternal components of the predisposition to preeclampsia. N Engl J Med. 2001 Mar 22;344(12):867–872. PubMed PMID: 11259719.
  • Arngrimsson R, Bjornsson S, Geirsson RT, et al. Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. Br J Obstet Gynaecol. 1990 Sep;97(9):762–769. PubMed PMID: 2242360.
  • George EM, Granger JP. Hypertension: A new genetic clue to unravel the origins of pre-eclampsia. Nat Rev Nephrol. 2017 Oct;13(10):599–600. PubMed PMID: 28869250.
  • Julier C, Delepine M, Keavney B, et al. Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. Hum Mol Genet. 1997 Nov;6(12):2077–2085. PubMed PMID: 9328471.
  • Ponighaus C, Speirs HJ, Morris BJ, et al. Xylosyltransferase gene variants and their role in essential hypertension. Am J Hypertens. 2009 Apr;22(4):432–436. PubMed PMID: 19197251.
  • Baima J, Nicolaou M, Schwartz F, et al. Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. Hypertension. 1999 Jul;34(1):4–7. PubMed PMID: 10406815.
  • Hilbert P, Lindpaintner K, Beckmann JS, et al. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature. 1991 Oct 10;353(6344):521–529. PubMed PMID: 1656270.
  • Wang RY, Chung CM, Fann CS, et al. Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study. Hum Hered. 2008;65(2):85–90. PubMed PMID: 17898539.
  • Mashalaba NN, Modissanyane FM, Kyi DH, et al.Geographic variation in the incidence of hypertension in pregnancy. World Health Organization International Collaborative Study of Hypertensive Disorders of Pregnancy. Am J Obstet Gynecol. 1988 Jan;158(1): 80–83. PubMed PMID: 2962500.

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