![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
[6]-Gingerol, a naturally occurring plant phenol, is one of the major components of fresh ginger (Zingiber officinale Roscoe, Zingiberaceae) and has diverse pharmacologic effects. Here, we describe its novel anti-oxidant, anti-apoptotic, and anti-inflammatory activities in vitro and in vivo. In vitro, pre-treatment with [6]-gingerol reduced UVB-induced intracellular reactive oxygen species levels, activation of caspase-3, -8, -9, and Fas expression. It also reduced UVB-induced expression and transactivation of COX-2. Translocation of NF-κB from cytosol to nucleus in HaCaT cells was inhibited by [6]-gingerol via suppression of IκBα phosphorylation (ser-32). Examination by EMSAs and immunohistochemistry showed that topical application of [6]-gingerol (30 μM) prior to UVB irradiation (5 kJ/m2) of hairless mice, also inhibited the induction of COX-2 mRNA and protein, as well as NF-κB translocation. These results suggest that [6]-gingerol could be an effective therapeutic agent providing protection against UVB-induced skin disorders.
| Abbreviations | ||
| ROS | = | reactive oxygen species |
| COX-2 | = | cyclooxygenase-2 |
| NF-κB | = | nuclear factor-kappaB |
| FADD | = | Fas-associated death domain |
| NAC | = | N-acetyl cysteine |
| IκB | = | inhibitor of NF-κB |
| Abbreviations | ||
| ROS | = | reactive oxygen species |
| COX-2 | = | cyclooxygenase-2 |
| NF-κB | = | nuclear factor-kappaB |
| FADD | = | Fas-associated death domain |
| NAC | = | N-acetyl cysteine |
| IκB | = | inhibitor of NF-κB |