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Original

[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo

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Pages 603-614 | Received 11 Nov 2006, Published online: 07 Jul 2009

References

  • Kim HJ, Kang SY, Kim SJ, Kim SH, Kim TY. Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin. Apoptosis 2004; 9: 449–456
  • Brenneisen P, Sies H, Scharffetter-Kochanek K. Ultraviolet-B irradiation and matrix metalloproteinases: From induction via signaling to initial events. Ann N Y Acad Sci 2002; 973: 31–43
  • Kulms D, Schwarz T. Mechanisms of UV-induced signal transduction. J Dermatol 2002; 29: 189–196
  • Patrick MH. Studies on thymine-derived UV photoproducts in DNA–I. Formation and biological role of pyrimidine adducts in DNA. Photochem Photobiol 1977; 25: 357–372
  • Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T, Brash DE. Sunburn and p53 in the onset of skin cancer. Nature 1994; 372: 773–776
  • Peter ME, Krammer PH. Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis. Curr Opin Immunol 1998; 10: 545–551
  • Ho JN, Lee YH, Park JS, Jun WJ, Kim HK, Hong BS, Shin DH, Cho HY. Protective effects of aucubin isolated from Eucommia ulmoides against UVB-induced oxidative stress in human skin fibroblasts. Biol Pharm Bull 2005; 28: 1244–1248
  • Cunningham ML, Krinsky NI, Giovanazzi SM, Peak MJ. Superoxide anion is generated from cellular metabolites by solar radiation and its components. J Free Radic Biol Med 1985; 1: 381–385
  • Hattori Y, Nishigori C, Tanaka T, Uchida K, Nikaido O, Osawa T, Hiai H, Imamura S, Toyokuni S. 8-hydroxy-2′-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol 1996; 107: 733–737
  • Vile GF, Tyrrell RM. UVA radiation-induced oxidative damage to lipids and proteins in vitro and in human skin fibroblasts is dependent on iron and singlet oxygen. Free Radic Biol Med 1995; 18: 721–730
  • Flohe L, Brigelius-Flohe R, Saliou C, Traber MG, Packer L. Redox regulation of NF-kappa B activation. Free Radic Biol Med 1997; 22: 1115–1126
  • Baeuerle PA, Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 1994; 12: 141–179
  • Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998; 16: 225–260
  • Fisher GJ, Datta SC, Talwar HS, Wang ZQ, Varani J, Kang S, Voorhees JJ. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 1996; 379: 335–339
  • Kitazawa M, Nakano T, Chuujou H, Shiojiri E, Iwasaki K, Sakamoto K. Intracellular redox regulation by a cystine derivative suppresses UV-induced NF-kappa B activation. FEBS Lett 2002; 526: 106–110
  • Saliou C, Rimbach G, Moini H, McLaughlin L, Hosseini S, Lee J, Watson RR, Packer L. Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Radic Biol Med 2001; 30: 154–160
  • Beak SM, Lee YS, Kim JA. NADPH oxidase and cyclooxygenase mediate the ultraviolet B-induced generation of reactive oxygen species and activation of nuclear factor-kappaB in HaCaT human keratinocytes. Biochimie 2004; 86: 425–429
  • Greaves MW, Sondergaard J. Pharmacologic agents released in ultraviolet inflammation studied by continuous skin pefusion. J Invest Dermatol 1970; 54: 365–367
  • Hruza LL, Pentland AP. Mechanisms of UV-induced inflammation. J Invest Dermatol 1993; 100: 35S–41S
  • Isoherranen K, Punnonen K, Jansen C, Uotila P. Ultraviolet irradiation induces cyclooxygenase-2 expression in keratinocytes. Br J Dermatol 1999; 140: 1017–1022
  • Soriani M, Luscher P, Tyrrell RM. Direct and indirect modulation of ornithine decarboxylase and cyclooxygenase by UVB radiation in human skin cells. Carcinogenesis 1999; 20: 727–732
  • Chun KS, Keum YS, Han SS, Song YS, Kim SH, Surh YJ. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis 2003; 24: 1515–1524
  • Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: A review. J Am Diet Assoc 1996; 96: 1027–1039
  • Soleas GJ, Diamandis EP, Goldberg DM. Wine as a biological fluid: History, production, and role in disease prevention. J Clin Lab Anal 1997; 11: 287–313
  • Bravo L. Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 1998; 56: 317–333
  • Park KK, Chun KS, Lee JM, Lee SS, Surh YJ. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett 1998; 129: 139–144
  • Bode AM, Ma WY, Surh YJ, Dong Z. Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Cancer Res 2001; 61: 850–853
  • Cadet J, Berger M, Douki T, Morin B, Raoul S, Ravanat JL, Spinelli S. Effects of UV and visible radiation on DNA-final base damage. Biol Chem 1997; 378: 1275–1286
  • Ashida M, Bito T, Budiyanto A, Ichihashi M, Ueda M. Involvement of EGF receptor activation in the induction of cyclooxygenase-2 in HaCaT keratinocytes after UVB. Exp Dermatol 2003; 12: 445–452
  • Stolk J, Hiltermann TJ, Dijkman JH, Verhoeven AJ. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am J Respir Cell Mol Biol 1994; 11: 95–102
  • Buckman SY, Gresham A, Hale P, Hruza G, Anast J, Masferrer J, Pentland AP. COX-2 expression is induced by UVB exposure in human skin: Implications for the development of skin cancer. Carcinogenesis 1998; 19: 723–729
  • Wang T, Zhang X, Li JJ. The role of NF-kappaB in the regulation of cell stress responses. Int Immunopharmacol 2002; 2: 1509–1520
  • Siebenlist U, Franzoso G, Brown K. Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol 1994; 10: 405–455
  • Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation. Genes Dev 1995; 9: 2723–2735
  • Kim SO, Kundu JK, Shin YK, Park JH, Cho MH, Kim TY, Surh YJ. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene 2005; 24: 2558–2567
  • Stege H, Roza L, Vink AA, Grewe M, Ruzicka T, Grether-Beck S, Krutmann J. Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin. Proc Natl Acad Sci USA 2000; 97: 1790–1795
  • Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 1997; 90: 405–413
  • Hu Y, Benedict MA, Ding L, Nunez G. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. Embo J 1999; 18: 3586–3595
  • Katiyar SK, Matsui MS, Elmets CA, Mukhtar H. Polyphenolic antioxidant ( − )-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. Photochem Photobiol 1999; 69: 148–153
  • Goldberg HJ, Viegas MM, Margolis BL, Schlessinger J, Skorecki KL. The tyrosine kinase activity of the epidermal-growth-factor receptor is necessary for phospholipase A2 activation. Biochem J 1990; 267: 461–465
  • Miller CC, Hale P, Pentland AP. Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation. J Biol Chem 1994; 269: 3529–3533
  • Pinnell SR. Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol 2003; 48: 1–19, quiz 20-12
  • Corsini E, Bruccoleri A, Marinovich M, Galli CL. In vitro mechanism(s) of ultraviolet-induced tumor necrosis factor-alpha release in a human keratinocyte cell line. Photodermatol Photoimmunol Photomed 1995; 11: 112–118
  • Tanaka S, Sato T, Akimoto N, Yano M, Ito A. Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro. Biochem Pharmacol 2004; 68: 433–439
  • Chen W, Tang Q, Gonzales MS, Bowden GT. Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. Oncogene 2001; 20: 3921–3926
  • Chun KS, Kim SH, Song YS, Surh YJ. Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin. Carcinogenesis 2004; 25: 713–722
  • Chun KS, Surh YJ. Signal transduction pathways regulating cyclooxygenase-2 expression: Potential molecular targets for chemoprevention. Biochem Pharmacol 2004; 68: 1089–1100
  • Reefman E, Limburg PC, Kallenberg CG, Bijl M. Apoptosis in human skin: Role in pathogenesis of various diseases and relevance for therapy. Ann N Y Acad Sci 2005; 1051: 52–63
  • Farber JL. Mechanisms of cell injury by activated oxygen species. Environ Health Perspect 1994; 10(102 Suppl)17–24
  • Sitailo LA, Tibudan SS, Denning MF. Activation of caspase-9 is required for UV-induced apoptosis of human keratinocytes. J Biol Chem 2002; 277: 19346–19352
  • Aragane Y, Kulms D, Metze D, Wilkes G, Poppelmann B, Luger TA, Schwarz T. Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J Cell Biol 1998; 140: 171–182
  • Kulms D, Poppelmann B, Yarosh D, Luger TA, Krutmann J, Schwarz T. Nuclear and cell membrane effects contribute independently to the induction of apoptosis in human cells exposed to UVB radiation. Proc Natl Acad Sci USA 1999; 96: 7974–7979
  • Takahashi H, Nakamura S, Asano K, Kinouchi M, Ishida-Yamamoto A, Iizuka H. Fas antigen modulates ultraviolet B-induced apoptosis of SVHK cells: Sequential activation of caspases 8, 3, and 1 in the apoptotic process. Exp Cell Res 1999; 249: 291–298
  • Murphy G, Young AR, Wulf HC, Kulms D, Schwarz T. The molecular determinants of sunburn cell formation. Exp Dermatol 2001; 10: 155–160

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