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Abstract
In this study, chitosan flake was micronized in a ball mill to make fine powder. The effects of the milling on properties of chitosan, such as particle size, molecular parameters, bulk density, crystalline structure, color, chemical structure, and solubility, were investigated. Results showed that the volume weight mean diameter (D[Citation4,Citation3]) of chitosan was reduced to 37.53 μm after 8 h of milling and extended milling did not cause a further decrease in particle size. After milling, the viscosity average molecular weight (Mv) of chitosan was decreased, but the degree of acetylation (DD) remained nearly unchanged. The bulk density of chitosan increased with increasing milling time. The crystalline structure of chitosan was destroyed by the milling. The ball-milling treatment deepened the color of chitosan. UV-vis spectra showed that new C=O groups might be formed during the milling process. Further, the micronized powders showed high dissolution rates in simulated gastric juice.
ACKNOWLEDGMENTS
This research was financially supported by the fund for 863 Project (Nos. 2007AA100401 and 2011AA090801), the National Natural Science Funds of China (20876068 and 20571034), the Science and Technology Plan Project of Guangdong Province (No. 2010B090400467), the guidance project of State Key Laboratory of Food Science and Technology (No. SKLF-MB-200805), and the Fund Project for Transformation of Scientific and Technological Achievements of Jiangsu Province (BA2009082).