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Review

Anticancer, antioxidant, ameliorative and therapeutic properties of kaempferol

, , , , , , , , , , & show all
Pages 1140-1166 | Received 16 Jan 2023, Accepted 16 Apr 2023, Published online: 28 Apr 2023
 

ABSTRACT

Kaempferol, found in various plants and foods, has gained attention as a useful flavonoid owing to its potential biological properties, including anticancer characteristics. Recent research studies suggest that kaempferol is effective in the inhibition and treatments of several forms of cancer, e.g. lung, ovarian, breast and lung cancer. One probable mechanism of action of kaempferol is its anti-inflammatory and antioxidant potentials, which may help to prevent DNA damage and inhibit the proliferation of cancerous cells. Besides triggering apoptosis in cancerous cells, Kaempferol may also inhibit the growth and relocation of cancerous cells. Moreover, kaempferol has a very wide range of bioactivities, involving anti-inflammatory and antioxidant effects. This includes understanding the optimal dosing and timing of kaempferol treatment, as well as the potential interactions with other medications and the long-term safety of kaempferol use. Overall, the available evidence and studies suggest that kaempferol may provide a potential natural agent for the prevention and treatments of cancers. Despite the promising findings in preclinical and clinical research, further research is needed to confirm its efficacy and understand the mechanisms of action, and to fully explore the potential of kaempferol in different cancers.

Acknowledgments

The authors acknowledge Muhammad Nawaz Shareef University of Agriculture Multan, and Kampala International University in Kampala, Uganda, for providing the facilities used in undertaking this study.

Disclosure statement

No potential conflict of interest was reported by the authors.

Consent for publication

All the authors on this manuscript gave their consent to publish.

Additional information

Funding

No funding was received to undergo the study