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Original Article

Treatment of atrophic vaginitis with topical conjugated equine estrogens in postmenopausal Asian women

, , , , , , , , & show all
Pages 312-318 | Received 09 Dec 2003, Accepted 31 Mar 2004, Published online: 27 Apr 2010
 

Abstract

Objective We investigated the effects of 2 months of treatment with topical estrogens on atrophic vaginitis and gynecological health in Asian women.

Study design Multicenter, open-label trial of 150 postmenopausal women age < 70 years with atrophic vaginitis. Women applied conjugated equine estrogens (CEE) vaginal cream (0.625 mg/g) once daily on days 1–21 of two 28-day cycles. Changes in the vaginal maturation index (VMI) from baseline to days 21 (month 1) and 49 (month 2) were the primary outcome. Physiological changes were assessed by the Genital Health Clinical Examination (GHCE).

Results The VMI was significantly improved (p < 0.001) from baseline at each assessment period. The significant improvement in GHCE from baseline after 1 month (p < 0.001) was maintained at 2 months.

Conclusions Vaginal treatment with CEE cream for 21 days of two consecutive 28-day cycles resulted in beneficial changes in the vaginal tissues and induced an overall genital health pattern more characteristic of the premenopausal state.

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