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Climacteric Volume 25, 2022 - Issue 4
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Case Report

First live birth in China after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency

X. Ruana Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7777-247XView further author information
ORCID Icon,
J. Dua Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
D. Lub Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
W. Duanc Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
F. Jina Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
W. Kongc Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
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Y. Wuc Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
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Y. Daia Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
S. Yana Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
C. Yina Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
Y. Lia Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
J. Chenga Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
C. Jiad Department of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
X. Liue Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
Q. Wuf Department of Ultrasound, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
M. Gua Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
R. Jua Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
X. Xua Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
Y. Yanga Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
J. Jina Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, ChinaView further author information
,
M. Korellg Department of Obstetrics and Gynecology, Johanna Etienne Hospital of Neuss, Neuss, GermanyView further author information
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M. Montagh Ilabcomm GmbH, Augustin, GermanyView further author information
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J. Liebenthroni UniCareD, University Cryobank for Assisted Reproductive Medicine and Fertility Protection at UniKiD, University Women’s Hospital Düsseldorf, Düsseldorf, GermanyView further author information
&
A. O. Muecka Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China;j University Women’s Hospital and Research Centre for Women’s Health, Department of Women’s Health, University of Tuebingen, Tuebingen, GermanyView further author information
 show all
Pages 421-424 | Received 04 Mar 2022, Accepted 04 Apr 2022, Published online: 03 May 2022
 
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Abstract

Objective

This article reports the first live birth after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency in China.

Methods

A patient with myelodysplastic syndrome received ovarian tissue cryopreservation before hematopoietic stem cell transplantation, and six ovarian cortex strips were thawed and transplanted into her peritoneal pocket 2 years later.

Results

Pregnancy occurred spontaneously 27 months after grafting, and a healthy girl was born at 38 weeks gestation. Until now, the child has developed normally without any major diseases.

Conclusions

We report the first live birth resulting from ovarian tissue cryopreservation and transplantation in China.

摘要

目的：本文报道应用冻存卵巢组织移植技术防治早发性卵巢功能不全中国首例活产。

方法：1例骨髓增生异常综合征患者在造血干细胞移植前接受卵巢组织冻存, 2年后, 其中6片卵巢皮质片复苏后移植到患者盆腹膜袋中。

结果：移植后27个月自然妊娠, 孕38周时分娩一名健康女婴。到目前为止, 婴儿发育正常, 无任何明显疾病。

结论：我们报道了卵巢组织冻存移植后中国首例活产。

Potential conflict of interest

Nil.

Source of funding

Supported by Beijing Natural Science Foundation [7202047]; Capital’s Funds for Health Improvement and Research [2020-2-2112]; Beijing Hospitals Authority’ Ascent Plan [DFL20181401]; Capital’s Funds for Health Improvement and Research [2016-2-2113]; Beijing Municipal Science & Technology Commission [Z161100000516143]; Beijing Hospitals Authority Clinical medicine Development of special funding support [XMLX201710].

Additional information

Funding

Supported by Beijing Natural Science Foundation [7202047]; Capital’s Funds for Health Improvement and Research [2020-2-2112]; Beijing Hospitals Authority’ Ascent Plan [DFL20181401]; Capital’s Funds for Health Improvement and Research [2016-2-2113]; Beijing Municipal Science & Technology Commission [Z161100000516143]; Beijing Hospitals Authority Clinical medicine Development of special funding support [XMLX201710].
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