Electrochemical investigation of allopurinol polymerised carbon paste electrode interface for epinephrine and folic acid sensing in pharmaceutical samples

ABSTRACT

The performance of simultaneous electro oxidation of epinephrine (EP) and folic acid (FA) was achieved at allopurinol polymerised carbon paste electrode (AlpM-CPE) by cyclic voltammetry (CV) method at physiological pH. The modified electrode showed remarkable sensing activity towards the electrooxidation of EP, involving irreversible 2-electronstransfer with adsorption-controlled kinetics. The results of varying few experimental parameters, for instance – scan rate, solution pH, concentration of the target analyte was examined. It was observed that, the anodic peak current (Ipa) is proportional to the concentration of EP in the range 51.02–318.18 μM with a calculated limit of detection (LOD) 0.46 µM by CV technique. The analytical applicability of the fabricated AlpM-CPE was examined for the resolve of EP in pharmaceutical sample and a good recovery results were observed.

KEYWORDS:

• Allopurinol
• epinephrine
• modified electrode
• electrochemical sensor
• voltammetry
• injection sample

5. Conflict of Interest

The authors declare no conflict of interest.

6. Credit author statement

A.B.T and P.S.G conceptualised the experimental idea and equally contributed. A.B.T, P.S.G and S.D.L performed the experiments. A.B.T and P.S.G took lead in the writing of the manuscript and equally contributed. S.N.D and B.E.K supervised the whole work. All authors agreed to the final version of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).