FFR_CT derived from computed tomography angiography: the experience in the UK

ABSTRACT

Introduction: Non-invasive fractional flow reserve derived from CT coronary angiography (FFR_CT) represents a novel technology to investigate coronary artery disease. The application of computational flow dynamics to anatomical data provides the clinician with a further functional assessment to inform decision-making in patients with coronary artery disease. In the UK FFR_CT has received medical technology approval for use since February 2017.

Areas covered: This article discusses the mathematical and physiological principles underpinning calculation of non-invasive fractional flow reserve (FFR), as well as discussing the differences between the commercially available technologies. Diagnostic accuracy, cost effectiveness and safety of non-invasive FFR from the early clinical trials is examined. Further to this the potential implications of the use of non-invasive FFR in clinical practice in the UK are discussed.

Expert commentary: Non-invasive FFR represents a promising comprehensive imaging technology providing both anatomical and physiological data to accurately diagnose obstructive coronary artery disease. The technology has yet to prove to be cost effective in ‘real world’ cohorts before becoming integrated into everyday clinical practice and guidelines in the United Kingdom.

KEYWORDS:

• FFR_CT
• coronary artery disease
• NICE
• United Kingdom
• CCTA

Acknowledgments

Stock images were provided with formal permission letter from HeartFlowTM and acknowledgements go to Jennie Kim and Campbell Rogers for providing these.

Declaration of interest

A Wragg and C Davies were co-principle investigators for ADVANCE registry and FORECAST trial. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Reviewer Disclosures

Peer reviewers on this manuscript have no relevant financial relationships or otherwise to disclose.

Additional information

Funding

This paper was not funded.