Evaluating cardiopulmonary function following acute pulmonary embolism

ABSTRACT

Introduction

Pulmonary embolism is a common cause of cardiopulmonary mortality and morbidity worldwide. Survivors of acute pulmonary embolism may experience dyspnea, report reduced exercise capacity, or develop overt pulmonary hypertension. Clinicians must be alert for these phenomena and appreciate the modalities and investigations available for evaluation.

Areas Covered

In this review, the current understanding of available contemporary imaging and physiologic modalities is discussed, based on available literature and professional society guidelines. The purpose of the review is to provide clinicians with an overview of these modalities, their strengths and disadvantages, and how and when these investigations can support the clinical work-up of patients post-pulmonary embolism.

Expert Opinion

Echocardiography is a first test in symptomatic patients post-pulmonary embolism, with ventilation/perfusion scanning vital to determination of whether there is chronic residual emboli. The role of computed tomography and magnetic resonance in assessing the pulmonary arterial tree in post-pulmonary embolism patients is evolving. Functional testing, in particular cardiopulmonary exercise testing, is emerging as an important modality to quantify and determine cause of functional limitation. It is possible that future investigations of the post-pulmonary embolism recovery period will better inform treatment decisions for acute pulmonary embolism patients.

KEYWORDS:

• Pulmonary embolism
• chronic thromboembolic pulmonary hypertension
• echocardiography computed tomography angiogram
• cardiopulmonary exercise testing
• cardiopulmonary function
• cardiovascular imaging
• chronic thromboembolic disease
• ventilation-perfusion scintigraphy

Acknowledgments

The authors would like to thank Eigil Høyrup for graphical support.

Declaration of Interests

AS Witkin has received consultant fees from United Therapeutics, unrelated to current work. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Reviewer Disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.