Evaluating cardiopulmonary function following acute pulmonary embolism

References

• Konstantinides SV, Meyer G, Becattini C, et al. ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2019;2020(41):543–603.
   Google Scholar
• Konstam MA, Kiernan MS, Bernstein D, et al. Evaluation and management of right-sided heart failure: a scientific statement from the American heart association. Circulation. 2018;137(20):e578–e622.
   PubMed Web of Science ®Google Scholar
• Turetz M, Sideris A, Friedman O, et al. Epidemiology, pathophysiology, and natural history of pulmonary embolism. Semin Intervent Rad. 2018;35(2):92–98.
   PubMed Web of Science ®Google Scholar
• Søgaard KK, Schmidt M, Pedersen L, et al. 30-year mortality after venous thromboembolism: a population-based cohort study. Circulation. 2014;130(10):829–836.
   PubMed Web of Science ®Google Scholar
• Huisman MV, Barco S, Cannegieter SC, et al. Pulmonary embolism. Nat Rev Dis Primers. 2018;4(1):18028.
   PubMedGoogle Scholar
• Stevens SM, Woller SC, Kreuziger LB, et al. Antithrombotic therapy for VTE disease: second update of the CHEST guideline and expert panel report. Chest. 2021;160(6):e545–e608.
   PubMed Web of Science ®Google Scholar
• Dalen JE, Banas JS, Brooks HL, et al. Resolution rate of acute pulmonary embolism in man. New Engl J Medicine. 1969;280(22):1194–1199.
   PubMed Web of Science ®Google Scholar
• Murphy ML, Bulloch RT. Factors influencing the restoration of blood flow following pulmonary embolization as determined by angiography and scanning. Circulation. 1968;38(6):1116–1126.
   PubMed Web of Science ®Google Scholar
• Picart G, Robin P, Tromeur C, et al. Predictors of residual pulmonary vascular obstruction after pulmonary embolism: results from a prospective cohort study. Thromb Res. 2020;194:1–7.
   PubMed Web of Science ®Google Scholar
• Chung T, Emmett L, Mansberg R, et al. Natural history of right ventricular dysfunction after acute pulmonary embolism. J Am Soc Echocardiogr. 2007;20(7):885–894.
   PubMed Web of Science ®Google Scholar
• Xi Q, Zhao Z, Liu Z, et al. The lowest VE/VCO2 ratio best identifies chronic thromboembolic pulmonary hypertension. Thromb Res. 2014;134(6):1208–1213.
   PubMed Web of Science ®Google Scholar
• Es J, Douma RA, Kamphuisen PW, et al. Clot resolution after 3 weeks of anticoagulant treatment for pulmonary embolism: comparison of computed tomography and perfusion scintigraphy. J Thromb Haemost. 2013;11(4):679–685.
   PubMed Web of Science ®Google Scholar
• Nijkeuter M, Hovens MMC, Davidson BL, et al. Resolution of thromboemboli in patients with acute pulmonary embolism a systematic review. Chest. 2006;129(1):192–197.
   PubMed Web of Science ®Google Scholar
• Keller K, Tesche C, Gerhold‐Ay A, et al. Quality of life and functional limitations after pulmonary embolism and its prognostic relevance. J Thromb Haemost. 2019;17(11):1923–1934.
   PubMed Web of Science ®Google Scholar
• Klok FA, van der HT, Exter PLD, et al., The post-PE syndrome: a new concept for chronic complications of pulmonary embolism. Blood Rev. 2014;28(6):221–226.
   PubMed Web of Science ®Google Scholar
• Klok FA, Ageno W, Ay C, et al. Optimal follow-up after acute pulmonary embolism: a position paper of the European Society of Cardiology working group on pulmonary circulation and right ventricular function, in collaboration with the European Society Of Cardiology working group on atherosclerosis and vascular biology, endorsed by the European Respiratory Society. Eur Heart J. 2021;43:183–189.
   Web of Science ®Google Scholar
• Hoeper MM, Mayer E, Simonneau G, et al. Chronic thromboembolic pulmonary hypertension. Circulation. 2006;113(16):2011–2020.
   PubMed Web of Science ®Google Scholar
• McCabe C, Dimopoulos K, Pitcher A, et al. Chronic thromboembolic disease following pulmonary embolism: time for a fresh look at old clot. Eur Respir J. 2020;55(4):1901934.
   PubMedGoogle Scholar
• Cho JH, Sridharan GK, Kim SH, et al., Right ventricular dysfunction as an echocardiographic prognostic factor in hemodynamically stable patients with acute pulmonary embolism: a meta-analysis. BMC Cardiovasc Disord. 2014;14(1):64.
   PubMedGoogle Scholar
• Barco S, Mahmoudpour SH, Planquette B, et al. Prognostic value of right ventricular dysfunction or elevated cardiac biomarkers in patients with low-risk pulmonary embolism: a systematic review and meta-analysis. Eur Heart J. 2019;40(11):902–910.
   PubMed Web of Science ®Google Scholar
• Stein PD, Fowler SE, Goodman LR, et al. Multidetector computed tomography for acute pulmonary embolism. New Engl J Med. 2006;354(22):2317–2327.
   PubMed Web of Science ®Google Scholar
• Becattini C, Agnelli G, Germini F, et al. Computed tomography to assess risk of death in acute pulmonary embolism: a meta-analysis. Eur Respir J. 2014;43(6):1678–1690.
   PubMed Web of Science ®Google Scholar
• Tunariu N, Gibbs SJR, and Win Z, et al., Ventilation–perfusion scintigraphy is more sensitive than multidetector CTPA in detecting chronic thromboembolic pulmonary disease as a treatable cause of pulmonary hypertension. J Nucl Med. 2007;48(5):680–684.
   PubMed Web of Science ®Google Scholar
• Dournes G, Verdier D, Montaudon M, et al. Dual-energy CT perfusion and angiography in chronic thromboembolic pulmonary hypertension: diagnostic accuracy and concordance with radionuclide scintigraphy. Eur Radiol. 2014;24(1):42–51.
   PubMed Web of Science ®Google Scholar
• Tsuchiya N, Ej van B, Ohno Y, et al. Magnetic resonance angiography for the primary diagnosis of pulmonary embolism: a review from the international workshop for pulmonary functional imaging. World J Radiol. 2018;10(6):52–64.
   PubMed Web of Science ®Google Scholar
• Zhang LJ, Zhou CS, Schoepf UJ, et al. Dual-energy CT lung ventilation/perfusion imaging for diagnosing pulmonary embolism. Eur Radiol. 2013;23(10):2666–2675.
   PubMed Web of Science ®Google Scholar
• Goldhaber SZ, Elliott CG. Acute pulmonary embolism: part I: epidemiology, pathophysiology, and diagnosis. Circulation. 2003;22(22):2726–2729.
   Google Scholar
• Lyhne MD, Kline JA, Nielsen-Kudsk JE, et al. Pulmonary vasodilation in acute pulmonary embolism – a systematic review. Pulm Circ. 2020;10(1):2045894019899775.
   Web of Science ®Google Scholar
• Naeije R, Brimioulle S, Dewachter L. Biomechanics of the right ventricle in health and disease (2013 Grover conference series). Pulm Circ. 2014;4(3):395–406.
   PubMed Web of Science ®Google Scholar
• Harjola V-P, Mebazaa A, Čelutkienė J, et al. Contemporary management of acute right ventricular failure: a statement from the heart failure association and the working group on pulmonary circulation and right ventricular function of the European Society of Cardiology: contemporary management of acute RV failure. Eur J Heart Fail. 2016;18(3):226–241.
   PubMed Web of Science ®Google Scholar
• Gerges C, Skoro-Sajer N, Lang IM. Right ventricle in acute and chronic pulmonary embolism (2013 Grover conference series). Pulm Circ. 2014;4(3):378–386.
   PubMed Web of Science ®Google Scholar
• Fields JM, Davis J, Girson L, et al. Transthoracic echocardiography for diagnosing pulmonary embolism: a systematic review and meta-analysis. J Am Soc Echocardiogr. 2017;30(7):714–23.e4.
   PubMed Web of Science ®Google Scholar
• Bova C, Greco F, Misuraca G, et al. Diagnostic utility of echocardiography in patients with suspected pulmonary embolism. Am J Emerg Med. 2003;21(3):180–183.
   PubMed Web of Science ®Google Scholar
• Kurnicka K, Lichodziejewska B, Goliszek S, et al. Echocardiographic pattern of acute pulmonary embolism: analysis of 511 consecutive patients. J Am Soc Echocardiogr. 2016;29(9):907–913.
   PubMed Web of Science ®Google Scholar
• Shah BN, Ahmadvazir S, Pabla JS, et al. The role of urgent transthoracic echocardiography in the evaluation of patients presenting with acute chest pain. Eur J Emerg Med. 2012;19(5):277–283.
   PubMed Web of Science ®Google Scholar
• Reza N, Dudzinski DM. Pulmonary embolism response teams. Curr Treat Options Cardiovasc Med. 2015;17(6):27.
   Google Scholar
• Rivera-Lebron B, McDaniel M, Ahrar K, et al. Diagnosis, treatment and follow up of acute pulmonary embolism: consensus practice from the PERT consortium. Clin Appl Thromb Hemost. 2019;25:1076029619853037.
   Web of Science ®Google Scholar
• Brailovsky Y, Allen S, Masic D, et al. Risk stratification of acute pulmonary embolism. Curr Treat Options Cardiovasc Med. 2021;23(7):48.
   Google Scholar
• Sanchez O, Trinquart L, and Colombet I, et al., Prognostic value of right ventricular dysfunction in patients with haemodynamically stable pulmonary embolism: a systematic review. Eur Heart J. 2008;29(12):1569–1577.
   PubMed Web of Science ®Google Scholar
• Kabrhel C, Okechukwu I, Hariharan P, et al. Factors associated with clinical deterioration shortly after PE. Thorax. 2014;69(9):835–842.
   PubMed Web of Science ®Google Scholar
• Grifoni S, Olivotto I, Cecchini P, et al. Short-term clinical outcome of patients with acute pulmonary embolism, normal blood pressure, and echocardiographic right ventricular dysfunction. Circulation. 2000;101(24):2817–2822.
   PubMed Web of Science ®Google Scholar
• Ribeiro A, Lindmarker P, Juhlin-Dannfelt A, et al. Echocardiography Doppler in pulmonary embolism: right ventricular dysfunction as a predictor of mortality rate. Am Heart J. 1997;134(3):479–487.
   PubMed Web of Science ®Google Scholar
• Lobo JL, Holley A, Tapson V, et al. Prognostic significance of tricuspid annular displacement in normotensive patients with acute symptomatic pulmonary embolism. J Thromb Haemost. 2014;12(7):1020–1027.
   PubMed Web of Science ®Google Scholar
• Jaff MR, McMurtry MS, Archer SL, et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American heart association. Circulation. 2011;123(16):1788–1830.
   PubMed Web of Science ®Google Scholar
• Dudzinski DM, Hariharan P, Parry BA, et al. Assessment of right ventricular strain by computed tomography versus echocardiography in acute pulmonary embolism. Acad Emerg Med. 2017;24(3):337–343.
   PubMed Web of Science ®Google Scholar
• Kjaergaard J, Schaadt BK, Lund JO, et al. Quantification of right ventricular function in acute pulmonary embolism: relation to extent of pulmonary perfusion defects. Eur J Echocardiogr. 2008;9(5):641–645.
   PubMed Web of Science ®Google Scholar
• Frémont B, Pacouret G, Jacobi D, et al. Prognostic value of echocardiographic right/left ventricular end-diastolic diameter ratio in patients with acute pulmonary embolism results from a monocenter registry of 1,416 patients. Chest. 2008;133(2):358–362.
   PubMed Web of Science ®Google Scholar
• Pruszczyk P, Goliszek S, Lichodziejewska B, et al. Prognostic value of echocardiography in normotensive patients with acute pulmonary embolism. JACC Cardiovasc Imaging. 2014;7(6):553–560.
   PubMed Web of Science ®Google Scholar
• Lyhne MD, Kabrhel C, Giordano N, et al. The echocardiographic ratio tricuspid annular plane systolic excursion/pulmonary arterial systolic pressure predicts short-term adverse outcomes in acute pulmonary embolism. Eur Heart J Cardiovasc Imaging. 2020;22(3):285–294.
   Web of Science ®Google Scholar
• Ciurzyński M, Kurnicka K, Lichodziejewska B, et al. Tricuspid Regurgitation Peak Gradient (TRPG)/Tricuspid Annulus Plane Systolic Excursion (TAPSE)- A novel parameter for stepwise echocardiographic risk stratification in normotensive patients with acute pulmonary embolism. Circ J. 2018;82(4):1179–1185.
   PubMed Web of Science ®Google Scholar
• Zanobetti M, Converti C, Conti A, et al. Prognostic value of emergency physician performed echocardiography in patients with acute pulmonary thromboembolism. West J Emerg Med. 2013;14(5):509–517.
   PubMedGoogle Scholar
• Kurnicka K, Lichodziejewska B, Ciurzyński M, et al. Peak systolic velocity of tricuspid annulus is inferior to tricuspid annular plane systolic excursion for 30 days prediction of adverse outcome in acute pulmonary embolism. Cardiol J. 2020;27(5):558–565.
   PubMed Web of Science ®Google Scholar
• Roberts JD, Forfia PR. Diagnosis and assessment of pulmonary vascular disease by Doppler echocardiography. Pulm Circ. 2011;1(2):160–181.
   PubMedGoogle Scholar
• Schmid E, Hilberath JN, Blumenstock G, et al. Tricuspid annular plane systolic excursion (TAPSE) predicts poor outcome in patients undergoing acute pulmonary embolectomy. Heart Lung Vessel. 2015;7(2):151–158.
   PubMedGoogle Scholar
• McConnell MV, Solomon SD, Rayan ME, et al. Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism. Am J Cardiol. 1996;78(4):469–473.
   PubMed Web of Science ®Google Scholar
• Park J-H, Kim JH, Lee J-H, et al. Evaluation of right ventricular systolic function by the analysis of tricuspid annular motion in patients with acute pulmonary embolism. J Cardiovasc Ultrasound. 2012;20(4):181–188.
   PubMedGoogle Scholar
• Garvey S, Dudzinski DM, Giordano N, et al. Pulmonary embolism with clot in transit: an analysis of risk factors and outcomes. Thromb Res. 2020;187:139–147.
   PubMed Web of Science ®Google Scholar
• Barrios D, Rosa-Salazar V, Morillo R, et al. Prognostic significance of right heart thrombi in patients with acute symptomatic pulmonary embolism systematic review and meta-analysis. Chest. 2017;151(2):409–416.
   PubMed Web of Science ®Google Scholar
• Dudzinski DM, Giri J, Rosenfield K. Interventional treatment of pulmonary embolism. Circ Cardiovasc Interv. 2017;10(2):e004345.
   PubMed Web of Science ®Google Scholar
• Dudzinski DM, Piazza G. Multidisciplinary pulmonary embolism response teams. Circulation. 2016;133(1):98–103.
   PubMed Web of Science ®Google Scholar
• Torbicki A, Galié N, Covezzoli A, et al. Right heart thrombi in pulmonary embolism results from the international cooperative pulmonary embolism registry. J Am Coll Cardiol. 2003;41(12):2245–2251.
   PubMed Web of Science ®Google Scholar
• Brailovsky Y, Lakhter V, Weinberg I, et al. Right ventricular outflow Doppler predicts low cardiac index in intermediate risk pulmonary embolism. Clin Appl Thromb Hemost. 2019;25:1076029619886062.
   Web of Science ®Google Scholar
• Yuriditsky E, Mitchell OJL, Sista AK, et al. Right ventricular stroke distance predicts death and clinical deterioration in patients with pulmonary embolism. Thromb Res. 2020;195:29–34.
   PubMed Web of Science ®Google Scholar
• Witkin A, Wilcox SR, Chang Y, et al. Impact of chronic right ventricular pressure overload in short-term outcomes of acute pulmonary embolism: a retrospective analysis. J Crit Care. 2019;51:1–5.
   PubMed Web of Science ®Google Scholar
• Perelas A, Dimou A, Saenz A, et al. Incidental findings on computed tomography angiography in patients evaluated for pulmonary embolism. Ann Am Thorac Soc. 2015;12(5):689–695.
   PubMed Web of Science ®Google Scholar
• Ferreira EV, Gazzana MB, Sarmento MB, et al. Alternative diagnoses based on CT angiography of the chest in patients with suspected pulmonary thromboembolism. J Bras Pneumol. 2015;42(1):35–41.
   Web of Science ®Google Scholar
• Green DB, Raptis CA, Garin IAH, et al. Negative computed tomography for acute pulmonary embolism important differential diagnosis considerations for acute dyspnea. Radiol Clin North Am. 2015;53(4):789–799.
   PubMed Web of Science ®Google Scholar
• Strijen MJL, Bloem JL, Monye W, et al. Helical computed tomography and alternative diagnosis in patients with excluded pulmonary embolism. J Thromb Haemost. 2005;3(11):2449–2456.
   PubMed Web of Science ®Google Scholar
• Miura S, Ohno Y, Kimura H, et al. Quantitative lung perfused blood volume imaging on dual-energy CT: capability for quantitative assessment of disease severity in patients with acute pulmonary thromboembolism. Acta Radiol. 2014;56(3):284–293.
   PubMed Web of Science ®Google Scholar
• Sakamoto A, Sakamoto I, Nagayama H, et al. Quantification of lung perfusion blood volume with dual-energy CT: assessment of the severity of acute pulmonary thromboembolism. Am J Roentgenol. 2014;203(2):287–291.
   PubMed Web of Science ®Google Scholar
• Qanadli SD, Hajjam ME, Vieillard-Baron A, et al. New CT index to quantify arterial obstruction in pulmonary embolism: comparison with angiographic index and echocardiography. Am J Roentgenol. 2001;176(6):1415–1420.
   PubMed Web of Science ®Google Scholar
• Miller GAH, Sutton GC, Kerr IH, et al. Comparison of streptokinase and heparin in treatment of isolated acute massive pulmonary embolism. Br Med J. 1971;2(5763):681.
   PubMedGoogle Scholar
• Mastora I, Remy-Jardin M, Masson P, et al. Severity of acute pulmonary embolism: evaluation of a new spiral CT angiographic score in correlation with echocardiographic data. Eur Radiol. 2003;13(1):29–35.
   PubMed Web of Science ®Google Scholar
• Choi K-J, Cha S-I, Shin K-M, et al. Factors determining clot resolution in patients with acute pulmonary embolism. Blood Coagul Fibrin. 2016;27(3):294–300.
   PubMed Web of Science ®Google Scholar
• John G, Marti C, Poletti P-A, et al. Hemodynamic indexes derived from computed tomography angiography to predict pulmonary embolism related mortality. Biomed Res Int. 2014;2014:363756–363758.
   PubMed Web of Science ®Google Scholar
• Schoepf UJ, Kucher N, Kipfmueller F, et al. Right ventricular enlargement on chest computed tomography. Circulation. 2004;110(20):3276–3280.
   PubMed Web of Science ®Google Scholar
• Meinel FG, Nance JW, Schoepf UJ, et al., Predictive value of computed tomography in acute pulmonary embolism: systematic review and meta-analysis. Am J Med. 2015;128(7):747–59.e2.
   PubMed Web of Science ®Google Scholar
• Ali H, Haddad D, Srinivasan A, et al. Correlation between non-gated chest CT and echocardiography in the assessment of the left ventricle. J Pulm Med Respir Res. 2018;4. 014.
   Google Scholar
• Barrios D, Morillo R, Lobo JL, et al. Assessment of right ventricular function in acute pulmonary embolism. Am Heart J. 2017;185:123–129.
   PubMed Web of Science ®Google Scholar
• Ammari Z, Hasnie AA, Ruzieh M, et al. Prognostic value of computed tomography versus echocardiography derived right to left ventricular diameter ratio in acute pulmonary embolism. Am J Med Sci. 2021;361(4):445–450.
   PubMed Web of Science ®Google Scholar
• Lyhne MD, Schultz JG, MacMahon PJ, et al. Septal bowing and pulmonary artery diameter on computed tomography pulmonary angiography are associated with short-term outcomes in patients with acute pulmonary embolism. Emerg Radiol. 2019;26(6):623–630.
   PubMed Web of Science ®Google Scholar
• Heidinger BH, DaBreo D, Kirkbride RR, et al. Risk assessment of acute pulmonary embolism utilizing coronary artery calcifications in patients that have undergone CT pulmonary angiography and transthoracic echocardiography. Eur Radiol. 2021;31(5):2809–2818.
   PubMed Web of Science ®Google Scholar
• Bonnefoy P-B, Prevot N, Mehdipoor G, et al. Ventilation/perfusion (V/Q) scanning in contemporary patients with pulmonary embolism: utilization rates and predictors of use in a multinational study. J Thromb Thrombolysis. 2022;53(4):829–840.
   PubMed Web of Science ®Google Scholar
• Stals MAM, Klok FA, Huisman MV. Diagnostic management of acute pulmonary embolism in special populations. Expert Rev Resp Med. 2020;14(7):729–736.
   PubMed Web of Science ®Google Scholar
• Tromeur C, van der PLM, Roux P-YL, et al. Computed tomography pulmonary angiography versus ventilation-perfusion lung scanning for diagnosing pulmonary embolism during pregnancy: a systematic review and meta-analysis. Haematologica. 2019;104(1):176–188.
   PubMed Web of Science ®Google Scholar
• Revel MP, Sanchez O, Couchons S, et al. Diagnostic accuracy of magnetic resonance imaging for an acute pulmonary embolism: results of the ‘IRM‐EP’ study. J Thromb Haemost. 2012;10(5):743–750.
   PubMed Web of Science ®Google Scholar
• Alzghoul BN, Reddy R, Chizinga M, et al. Pulmonary embolism in acute asthma exacerbation: clinical characteristics, prediction model and hospital outcomes. Lung. 2020;198(4):661–669.
   PubMed Web of Science ®Google Scholar
• Aleva FE, Voets LWLM, Simons SO, et al. Prevalence and localization of pulmonary embolism in unexplained acute exacerbations of COPD. Chest. 2017;151(3):544–554.
   PubMed Web of Science ®Google Scholar
• Ribeiro A, Lindmarker P, Johnsson H, et al. Pulmonary embolism: one-year follow-up with echocardiography Doppler and five-year survival analysis. Circulation. 1999;99(10):1325–1330.
   PubMed Web of Science ®Google Scholar
• Albaghdadi MS, Dudzinski DM, Giordano N, et al., Cardiopulmonary exercise testing in patients following massive and submassive pulmonary embolism. J Am Heart Assoc. 2018;7(5):e006841.
   PubMed Web of Science ®Google Scholar
• Vavera Z, Elias P, Ryska P, et al. Computed tomography pulmonary embolism residual index (CTPER-index): a simple tool for pulmonary embolism residual description. Anatol J Cardiol. 2016;16(4):270–275.
   PubMed Web of Science ®Google Scholar
• Ciurzyński M, Kurzyna M, Bochowicz A, et al. Long‐term effects of acute pulmonary embolism on echocardiographic Doppler indices and functional capacity. Clin Cardiol. 2004;27(12):693–697.
   PubMed Web of Science ®Google Scholar
• Sista AK, Miller LE, Kahn SR, et al. * Persistent right ventricular dysfunction, functional capacity limitation, exercise intolerance, and quality of life impairment following pulmonary embolism: systematic review with meta-analysis. Vasc Med. 2017;22(1):37–43.
   PubMed Web of Science ®Google Scholar
• Kline JA, Steuerwald MT, and Marchick MR, et al., Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism frequency of persistent or subsequent elevation in estimated pulmonary artery pressure. Chest. 2009;136(5):1202–1210.
   PubMed Web of Science ®Google Scholar
• Lachant D, Bach C, Wilson B, et al. Clinical and imaging outcomes after intermediate- or high-risk pulmonary embolus. Pulm Circ. 2020;10(3):204589402095201.
   Web of Science ®Google Scholar
• Stevinson BG, Hernandez-Nino J, Rose G, et al. Echocardiographic and functional cardiopulmonary problems 6 months after first-time pulmonary embolism in previously healthy patients. Eur Heart J. 2007;28(20):2517–2524.
   PubMed Web of Science ®Google Scholar
• Barco S, Russo M, Vicaut E, et al. Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial. Clin Res Cardiol. 2019;108(7):772–778.
   PubMed Web of Science ®Google Scholar
• Park JS, Ahn J, Choi JH, et al. The predictive value of echocardiography for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism in Korea. Korean J Intern Med. 2017;32(1):85–94.
   PubMed Web of Science ®Google Scholar
• Otero R, Oribe M, Ballaz A, et al., Echocardiographic assessment of pulmonary arterial pressure in the follow-up of patients with pulmonary embolism. Thromb Res. 2011;127(4):303–308.
   PubMed Web of Science ®Google Scholar
• Klok FA, Couturaud F, Delcroix M, et al. Diagnosis of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Eur Respir J. 2020;55(6):2000189.
   PubMed Web of Science ®Google Scholar
• Galiè N, Humbert M, Vachiery J-L, et al. ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertensionThe joint task force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): endorsed by: association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Respir J. 2015;2015(46):903–975.
   Google Scholar
• Witkin AS, Channick RN. Chronic thromboembolic pulmonary hypertension: the end result of pulmonary embolism. Curr Cardiol Rep. 2015;17(8):63.
   PubMed Web of Science ®Google Scholar
• Wang M, Wu D, and Ma R, et al., Comparison of V/Q SPECT and CT angiography for the diagnosis of chronic thromboembolic pulmonary hypertension. Radiology. 2020;296(2):420–429.
   PubMed Web of Science ®Google Scholar
• Rajaram S, Swift AJ, and Telfer A, et al., 3D contrast-enhanced lung perfusion MRI is an effective screening tool for chronic thromboembolic pulmonary hypertension: results from the ASPIRE registry. Thorax. 2013;68(7):677–678.
   PubMed Web of Science ®Google Scholar
• Ley S, Ley-Zaporozhan J, Pitton MB, et al. Diagnostic performance of state-of-the-art imaging techniques for morphological assessment of vascular abnormalities in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Eur Radiol. 2012;22(3):607–616.
   PubMed Web of Science ®Google Scholar
• Reichelt A, Hoeper MM, Galanski M, et al. Chronic thromboembolic pulmonary hypertension: evaluation with 64-detector row CT versus digital substraction angiography. Eur J Radiol. 2009;71(1):49–54.
   PubMed Web of Science ®Google Scholar
• Ley S, Kauczor H-U, Heussel CP, et al. Value of contrast-enhanced MR angiography and helical CT angiography in chronic thromboembolic pulmonary hypertension. Eur Radiol. 2003;13(10):2365–2371.
   PubMed Web of Science ®Google Scholar
• Willemink MJ, van EHW, Koobs L, et al. CT evaluation of chronic thromboembolic pulmonary hypertension. Clin Radiol. 2012;67(3):277–285.
   PubMed Web of Science ®Google Scholar
• Hasegawa I, Boiselle PM, Hatabu H. Bronchial artery dilatation on MDCT scans of patients with acute pulmonary embolism: comparison with chronic or recurrent pulmonary embolism. Am J Roentgenol. 2004;182(1):67–72.
   PubMed Web of Science ®Google Scholar
• King MA, Ysrael M, Bergin CJ. Chronic thromboembolic pulmonary hypertension: CT findings. Am J Roentgenol. 1998;170(4):955–960.
   PubMed Web of Science ®Google Scholar
• Wittram C, Kalra MK, Maher MM, et al. Acute and chronic pulmonary emboli: angiography–CT correlation. Am J Roentgenol. 2006;186(6_supplement_2):S421–9.
   PubMed Web of Science ®Google Scholar
• Mahmud E, Madani MM, Kim NH, et al. Chronic thromboembolic pulmonary hypertension evolving therapeutic approaches for operable and inoperable disease. J Am Coll Cardiol. 2018;71(21):2468–2486.
   PubMed Web of Science ®Google Scholar
• Delcroix M, Vonk-Noordegraaf A, Fadel E, et al. Vascular and right ventricular remodelling in chronic thromboembolic pulmonary hypertension. Eur Respir J. 2012;41(1):224–232.
   PubMed Web of Science ®Google Scholar
• Endrys J, Hayat N, Cherian G. Comparison of bronchopulmonary collaterals and collateral blood flow in patients with chronic thromboembolic and primary pulmonary hypertension. Heart. 1997;78(2):171.
   PubMed Web of Science ®Google Scholar
• Heinrich M, Uder M, Tscholl D, et al. CT scan findings in chronic thromboembolic pulmonary hypertension: predictors of hemodynamic improvement after pulmonary thromboendarterectomy. Chest. 2005;127(5):1606–1613.
   PubMed Web of Science ®Google Scholar
• Kauczor H-U, Schwickert HC, Mayer E, et al. Spiral CT of bronchial arteries in chronic thromboembolism. J Comput Assist Tomo. 1994;18(6):855–861.
   PubMed Web of Science ®Google Scholar
• Ruigrok D, Meijboom LJ, Westerhof BE, et al., Right ventricular load and function in chronic thromboembolic pulmonary hypertension: differences between proximal and distal chronic thromboembolic pulmonary hypertension. Am J Respir Crit Care Med. 2019;199(9):1163–1166.
   PubMed Web of Science ®Google Scholar
• Remy-Jardin M, Delhaye D, Teisseire A, et al. MDCT of right ventricular function: impact of methodologic approach in estimation of right ventricular ejection fraction, part 2. Am J Roentgenol. 2006;187(6):1605–1609.
   PubMed Web of Science ®Google Scholar
• Devaraj A, Wells AU, Meister MG, et al. Detection of pulmonary hypertension with multidetector CT and echocardiography alone and in combination. Radiology. 2010;254(2):609–616.
   PubMed Web of Science ®Google Scholar
• Narechania S, Renapurkar R, Heresi GA. Mimickers of chronic thromboembolic pulmonary hypertension on imaging tests: a review. Pulm Circ. 2020;10(1):2045894019882620.
   Web of Science ®Google Scholar
• Masy M, Giordano J, Petyt G, et al., Dual-energy CT (DECT) lung perfusion in pulmonary hypertension: concordance rate with V/Q scintigraphy in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH). Eur Radiol. 2018;28(12):5100–5110.
   PubMed Web of Science ®Google Scholar
• Hong YJ, Kim JY, Choe KO, et al. Different perfusion pattern between acute and chronic pulmonary thromboembolism: evaluation with two-phase dual-energy perfusion CT. Am J Roentgenol. 2013;200(4):812–817.
   PubMed Web of Science ®Google Scholar
• Giordano J, Khung S, Duhamel A, et al. Lung perfusion characteristics in pulmonary arterial hypertension (PAH) and peripheral forms of chronic thromboembolic pulmonary hypertension (pCTEPH): dual-energy CT experience in 31 patients. Eur Radiol. 2016;27(4):1631–1639.
   PubMed Web of Science ®Google Scholar
• Tsutsumi Y, Iwano S, Okumura N, et al. Assessment of severity in chronic thromboembolic pulmonary hypertension by quantitative parameters of dual-energy computed tomography. J Comput Assist Tomo. 2020;44(4):578–585.
   PubMed Web of Science ®Google Scholar
• Saeedan MB, Bullen J, Heresi GA, et al. Morphologic and functional dual-energy CT parameters in patients with chronic thromboembolic pulmonary hypertension and chronic thromboembolic disease. Am J Roentgenol. 2020;215(6):1335–1341.
   PubMed Web of Science ®Google Scholar
• Koike H, Sueyoshi E, Sakamoto I, et al. Quantification of lung perfusion blood volume (lung PBV) by dual-energy CT in patients with chronic thromboembolic pulmonary hypertension (CTEPH) before and after balloon pulmonary angioplasty (BPA): preliminary results. Eur J Radiol. 2016;85(9):1607–1612.
   PubMed Web of Science ®Google Scholar
• Lu G-M, Wu S-Y, Yeh BM, et al. Dual-energy computed tomography in pulmonary embolism. Br J Radiol. 2010;83(992):707–718.
   PubMed Web of Science ®Google Scholar
• Desai A, Malaisrie SC, Cuttica M, et al. Dual-energy computed tomography as an alternative noninvasive study for evaluation of chronic thromboembolic pulmonary hypertension postoperatively. Circ Cardiovasc Imaging. 2020;13(5):e010168.
   PubMed Web of Science ®Google Scholar
• Alsady TM, Kaireit TF, Behrendt L, et al. Comparison of dual-energy computer tomography and dynamic contrast-enhanced MRI for evaluating lung perfusion defects in chronic thromboembolic pulmonary hypertension. Plos One. 2021;16(6):e0251740.
   PubMed Web of Science ®Google Scholar
• Zhang LJ, Yang GF, Zhao YE, et al. Detection of pulmonary embolism using dual-energy computed tomography and correlation with cardiovascular measurements: a preliminary study. Acta Radiol. 2009;50(8):892–901.
   PubMed Web of Science ®Google Scholar
• Delcroix M, Torbicki A, Gopalan D, et al., ERS statement on chronic thromboembolic pulmonary hypertension. Eur Respir J. 2021;57(6):2002828.
   PubMed Web of Science ®Google Scholar
• Kim NH, Delcroix M, Jais X, et al. Chronic thromboembolic pulmonary hypertension. Eur Respir J. 2019;53(1):1801915.
   PubMed Web of Science ®Google Scholar
• Derenoncourt P-R, Felder GJ, Royal HD, et al. Ventilation-perfusion scan: a primer for practicing radiologists. Radiographics. 2021;41(7):2047–2070.
   PubMed Web of Science ®Google Scholar
• Roach PJ, Schembri GP, Bailey DL. V/Q scanning using SPECT and SPECT/CT. J Nucl Med. 2013;54(9):1588–1596.
   PubMed Web of Science ®Google Scholar
• He J, Fang W, Lv B, et al. Diagnosis of chronic thromboembolic pulmonary hypertension. Nucl Med Commun. 2012;33(5):459–463.
   PubMed Web of Science ®Google Scholar
• Chopard R, Genet B, Ecarnot F, et al. Detection of residual pulmonary vascular obstruction by ventilation-perfusion lung scan late after a first pulmonary embolism. Am J Cardiol. 2017;119(11):1883–1889.
   PubMed Web of Science ®Google Scholar
• Meneveau N, Ider O, Seronde M-F, et al. Long-term prognostic value of residual pulmonary vascular obstruction at discharge in patients with intermediate- to high-risk pulmonary embolism. Eur Heart J. 2013;34(9):693–701.
   PubMed Web of Science ®Google Scholar
• Sanchez O, Helley D, Couchon S, et al. Perfusion defects after pulmonary embolism: risk factors and clinical significance. J Thromb Haemost. 2010;8(6):1248–1255.
   PubMed Web of Science ®Google Scholar
• Phillips DB, Collins SÉ, Stickland MK. Measurement and interpretation of exercise ventilatory efficiency. Front Physiol. 2020;11:659.
   PubMed Web of Science ®Google Scholar
• Kline JA, Meek S, Boudrow D, et al. Use of the alveolar dead space fraction (Vd/Vt) and plasma D‐dimers to exclude acute pulmonary embolism in ambulatory patients. Acad Emerg Med. 1997;4(9):856–863.
   PubMed Web of Science ®Google Scholar
• Piirilä P, Laiho M, Mustonen P, et al. Reduction in membrane component of diffusing capacity is associated with the extent of acute pulmonary embolism. Clin Physiol Funct Imaging. 2011;31(3):196–202.
   PubMed Web of Science ®Google Scholar
• Topilsky Y, Hayes CL, Khanna AD, et al. Cardiopulmonary exercise test in patients with subacute pulmonary emboli. Heart Lung. 2012;41(2):125–136.
   PubMed Web of Science ®Google Scholar
• Huang D, Guo J, Yang W, et al. Exercise capacity and ventilatory efficiency in patients with pulmonary embolism after short duration of anticoagulation therapy. Am J Med Sci. 2020;359(3):140–146.
   PubMed Web of Science ®Google Scholar
• Yan -W-W, Wang L-M, Che L, et al. Quantitative evaluation of cardiopulmonary functional reserve in treated patients with pulmonary embolism. Chin Med J (Engl). 2012;125(3):465–469.
   PubMed Web of Science ®Google Scholar
• Kahn SR, Hirsch AM, Akaberi A, et al. Functional and exercise limitations after a first episode of pulmonary embolism results of the ELOPE prospective cohort study. Chest. 2017;151(5):1058–1068.
   PubMed Web of Science ®Google Scholar
• Johns CS, Wild JM, Rajaram S, et al. Identifying at-risk patients with combined pre- and postcapillary pulmonary hypertension using interventricular septal angle at cardiac MRI. Radiology. 2018;289(1):61–68.
   PubMed Web of Science ®Google Scholar
• Swift AJ, Wild JM, Nagle SK, et al. Quantitative magnetic resonance imaging of pulmonary hypertension. J Thorac Imaging. 2014;29(2):68–79.
   PubMed Web of Science ®Google Scholar
• Hagger D, Condliffe R, Woodhouse N, et al. Ventricular mass index correlates with pulmonary artery pressure and predicts survival in suspected systemic sclerosis-associated pulmonary arterial hypertension. Rheumatology. 2009;48(9):1137–1142.
   PubMed Web of Science ®Google Scholar
• Saunders LC, Hughes PJC, and Alabed S, et al., Integrated cardiopulmonary MRI assessment of pulmonary hypertension. J Magn Reson Imaging. 2022;55(3):633–652.
   PubMed Web of Science ®Google Scholar
• Quail MA, Knight DS, Steeden JA, et al. Noninvasive pulmonary artery wave intensity analysis in pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2015;308(12):H1603–11.
   PubMed Web of Science ®Google Scholar
• Johns CS, Swift AJ, Rajaram S, et al. Lung perfusion: MRI vs. SPECT for screening in suspected chronic thromboembolic pulmonary hypertension. J Magn Reson Imaging. 2017;46(6):1693–1697.
   PubMed Web of Science ®Google Scholar
• Marshall H, Kiely DG, Parra-Robles J, et al. Magnetic resonance imaging of ventilation and perfusion changes in response to pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. Am J Respir Crit Care Med. 2014;190(5):e18–e19.
   PubMedGoogle Scholar
• Mai VM, Liu B, Li W, et al. Influence of oxygen flow rate on signal and T1 changes in oxygen‐enhanced ventilation imaging. J Magn Reson Imaging. 2002;16(1):37–41.
   PubMed Web of Science ®Google Scholar
• Rajaram S, Swift AJ, Capener D, et al. Diagnostic accuracy of contrast-enhanced MR angiography and unenhanced proton MR imaging compared with CT pulmonary angiography in chronic thromboembolic pulmonary hypertension. Eur Radiol. 2012;22(2):310–317.
   PubMed Web of Science ®Google Scholar
• Voskrebenzev A, Gutberlet M, Klimeš F, et al. Feasibility of quantitative regional ventilation and perfusion mapping with phase‐resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients. Magn Reson Med. 2018;79(4):2306–2314.
   PubMed Web of Science ®Google Scholar
• Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–968.
   PubMed Web of Science ®Google Scholar
• Suda R, Tanabe N, Ishida K, et al. Prognostic and pathophysiological marker for patients with chronic thromboembolic pulmonary hypertension: usefulness of diffusing capacity for carbon monoxide at diagnosis. Respirology. 2017;22(1):179–186.
   PubMed Web of Science ®Google Scholar
• Akizuki M, Serizawa N, Ueno A, et al. Effect of balloon pulmonary angioplasty on respiratory function in patients with chronic thromboembolic pulmonary hypertension. Chest. 2017;151(3):643–649.
   PubMed Web of Science ®Google Scholar
• Li X, Zhang Y, Luo Q, et al. Diffusing capacity for carbon monoxide predicts response to balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension. Front Cardiovasc Med. 2021;8:762267.
   PubMed Web of Science ®Google Scholar
• Laboratories AC on PS for CPF. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2012;166:111–117.
   Google Scholar
• Chow V, Ng ACC, Seccombe L, et al. Impaired 6-min walk test, heart rate recovery and cardiac function post pulmonary embolism in long-term survivors. Resp Med. 2014;108(10):1556–1565.
   PubMed Web of Science ®Google Scholar
• Taboada D, Pepke-Zaba J, Jenkins DP, et al. Outcome of pulmonary endarterectomy in symptomatic chronic thromboembolic disease. Eur Respir J. 2014;44(6):1635–1645.
   PubMed Web of Science ®Google Scholar
• Inami T, Kataoka M, Kikuchi H, et al. Balloon pulmonary angioplasty for symptomatic chronic thromboembolic disease without pulmonary hypertension at rest. Int J Cardiol. 2019;289:116–118.
   PubMed Web of Science ®Google Scholar
• Konstantinides SV, Vicaut E, Danays T, et al. Impact of thrombolytic therapy on the long-term outcome of intermediate-risk pulmonary embolism. J Am Coll Cardiol. 2017;69:1536–1544.
   PubMed Web of Science ®Google Scholar
• Kucher N, Boekstegers P, Müller OJ, et al. Randomized, controlled trial of ultrasound-assisted catheter-directed thrombolysis for acute intermediate-risk pulmonary embolism. Circulation. 2014;129(4):479–486.
   PubMed Web of Science ®Google Scholar