Abstract
This work aimed to investigate the α-glucosidase inhibitor from the roots of Glycyrrhiza uralensis Fisch. Seven flavonoids were isolated, and the total content of compounds 1–7 were more than 50% in Glycyrrhiza total flavones (GTF), and the content of compound 1 and 2 was abundant in GTF. The results of the α-glucosidase inhibitory activities indicated that compounds 1–6 and GTF respectively with the IC50 values of 31.303, 30.263, 23.363, 19.528, 10.854, 26.454 and 21.641 μg/mL exhibited the more potent activity than acarbose with the IC50 values of 38.995 μg/mL. These result suggested that Glycyrrhiza flavonoids may become a valid alternative of potential basis for new hypoglycaemic and antidiabetic agents.
![](/cms/asset/25eb014b-5454-4123-875c-390cd8c6ba45/gnpl_a_1114940_uf0001_oc.jpg)
Disclosure statement
No potential conflict of interest was reported by the authors.
Funding
This project was supported by Science & Technology Pillar program Foundation of Gansu Province [grant number 1204FKC151]; the National Natural Science Foundation of China [grant number 81273440].