Biodegradation and Medical Application of Microbial Poly(3-Hydroxybutyrate)

M. I. Artsis General Institute of Chemical Physics, Russian Academy of Sciences, Kosygin str. 4, 119991, Moscow, Russia

A. P. Bonartsev A. N. Bach's Institute of Biochemistry, Russian Academy of Sciences, Leninskii prosp. 33, 119071, Moscow, Russia; Faculty of Biology, Moscow State University, Leninskie gory 1-12, 119992, Moscow, Russia

A. L. Iordanskii General Institute of Chemical Physics, Russian Academy of Sciences, Kosygin str. 4, 119991, Moscow, Russia

G. A. Bonartseva A. N. Bach's Institute of Biochemistry, Russian Academy of Sciences, Leninskii prosp. 33, 119071, Moscow, Russia

G. E. Zaikov General Institute of Chemical Physics, Russian Academy of Sciences, Kosygin str. 4, 119991, Moscow, Russia

Abstract

This review is designed to be a comprehensive source for biodegradable polymer: poly(3-hydroxybutyrate)—PHB research, including fundamental structure/property relationships and biodegradation kinetics for samples of different geometry. In addition to presenting the scientific framework for the advances in PHB research, this review focuses on applications of PHB in biomedicine and environment with a discussion on commercial applications and health/safety concerns for biodegradable materials.

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Acknowledgements

This review was supported by grant no. 06-04-49339 and 08-03-00929 from the Russian Foundation for Basic Research (RFBR) and by grant no. 07-II-10 from Foundation for Assistance to Small Innovative Enterprises (FASIE).

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