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Original Articles

Biodegradation and Medical Application of Microbial Poly(3-Hydroxybutyrate)

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Pages 232-262 | Received 15 Jul 2011, Accepted 15 Sep 2011, Published online: 14 Feb 2012

References

  • Chen , G. Q. and Wu , Q. 2005 . The application of polyhydroxyalkanoates as tissue engineering materials . Biomaterials , 26 ( 33 ) : 6565 – 6578 .
  • Lenz , R. W. and Marchessault , R. H. 2005 . Bacterial polyesters: biosynthesis, biodegradable plastics and biotechnology . Biomacromolecules , 6 ( 1 ) : 1 – 8 .
  • Anderson , A. J. and Dawes , E. A. 1990 . Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates . Microbiological Reviews , 54 ( 4 ) : 450 – 472 .
  • Jendrossek , D. and Handrick , R. 2002 . Microbial degradation of polyhydroxyalkanoates . Annu. Rev. Microbiol. , 56 : 403 – 432 .
  • Kim , D. Y. and Rhee , Y. H. 2003 . Biodegradation of microbial and synthetic polyesters by fungi . Appl. Microbiol. Biotechnol. , 61 : 300 – 308 .
  • Steinbuchel , A. and Lutke-Eversloh , T. 2003 . Metabolic engineering and pathway construction for biotechnological production of relevant polyhydroxyalkanoates in microorganisms . Biochem. Eng. J. , 16 : 81 – 96 .
  • Marois , Y. , Zhang , Z. , Vert , M. , Deng , X. , Lenz , R. and Guidoin , R. 1999 . Hydrolytic and enzymatic incubation of polyhydroxyoctanoate (PHO): a short-term in vitro study of a degradable bacterial polyester . J. Biomater. Sci. Polym. Ed. , 10 : 483 – 499 .
  • Abe , H. and Doi , Y. 2002 . Side-chain effect of second monomer units on crystalline morphology, thermal properties, and enzymatic degradability for random copolyesters of (R)-3-hydroxybutyric acid with (R)-3-hydroxyalkanoic acids . Biomacromolecules , 3 ( 1 ) : 133 – 138 .
  • Renstad , R. , Karlsson , S. and Albertsson , A. C. 1999 . The influence of processing induced differences in molecular structure on the biological and non-biological degradation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate), P(3-HB-co-3-HV) . Polym. Degrad. Stab. , 63 : 201 – 211 .
  • Qu , X. H. , Wu , Q. , Zhang , K. Y. and Chen , G. Q. 2006 . In vivo studies of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) based polymers: biodegradation and tissue reactions . Biomaterials , 27 ( 19 ) : 3540 – 3548 (c) .
  • Freier , T. , Kunze , C. , Nischan , C. , Kramer , S. , Sternberg , K. , Sass , M. , Hopt , U. T. and Schmitz , K. P. 2002 . In vitro and in vivo degradation studies for development of a biodegradable patch based on poly(3-hydroxybutyrate) . Biomaterials , 23 ( 13 ) : 2649 – 2657 .
  • Kunze , C. , Edgar Bernd , H. , Androsch , R. , Nischan , C. , Freier , T. , Kramer , S. , Kramp , B. and Schmitz , K. P. 2006 . In vitro and in vivo studies on blends of isotactic and atactic poly (3-hydroxybutyrate) for development of a dura substitute material . Biomaterials , 27 ( 2 ) : 192 – 201 (a) .
  • Gogolewski , S. , Jovanovic , M. , Perren , S. M. , Dillon , J. G. and Hughes , M. K. 1993 . Tissue response and in vivo degradation of selected polyhydroxyacids: polylactides (PLA), poly(3-hydroxybutyrate) (PHB), and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB/VA) . J. Biomed. Mater. Res. , 27 ( 9 ) : 1135 – 1148 .
  • Borkenhagen , M. , Stoll , R. C. , Neuenschwander , P. , Suter , U. W. and Aebischer , P. 1998 . In vivo performance of a new biodegradable polyester urethane system used as a nerve guidance channel . Biomaterials , 19 ( 23 ) : 2155 – 2165 .
  • Hazari , A. , Johansson-Ruden , G. , Junemo-Bostrom , K. , Ljungberg , C. , Terenghi , G. , Green , C. and Wiberg , M. 1999 . A new resorbable wrap-around implant as an alternative nerve repair technique . Journal of Hand Surgery (British and European Volume , 24B ( 3 ) : 291 – 295 (a) .
  • Hazari , A. , Wiberg , M. , Johansson-Rudén , G. , Green , C. and Terenghi , G. 1999 . A resorbable nerve conduit as an alternative to nerve autograft . British J. Plastic Surgery , 52 : 653 – 657 (b) .
  • Miller , N. D. and Williams , D. F. 1987 . On the biodegradation of poly-beta-hydroxybutyrate (PHB) homopolymer and poly-beta-hydroxybutyrate-hydroxyvalerate copolymers . Biomaterials , 8 ( 2 ) : 129 – 137 .
  • Shishatskaya , E. I. , Volova , T. G. , Gordeev , S. A. and Puzyr , A. P. 2005 . Degradation of P(3HB) and P(3HB-co-3HV) in biological media . J. Biomater. Sci. Polym. Ed. , 16 ( 5 ) : 643 – 657 .
  • Saito , T. , Tomita , K. , Juni , K. and Ooba , K. 1991 . In vivo and in vitro degradation of poly(3-hydroxybutyrate) in rat . Biomaterials , 12 ( 3 ) : 309 – 312 .
  • Koyama , N. and Doi , Y. 1995 . Morphology and biodegradability of a binary blend of poly((R)-3-hydroxybutyric acid) and poly((R,S)-lactic acid) . Can. J. Microbiol. , 41 ( Suppl. 1 ) : 316 – 322 .
  • Doi , Y. , Kanesawa , Y. , Kunioka , M. and Saito , T. 1990a . Biodegradation of microbial copolyesters: poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and poly(3-hydroxybutyrate-co-4-hydroxybutyrate) . Macromolecules , 23 : 26 – 31 .
  • Holland , S. J. , Jolly , A. M. , Yasin , M. and Tighe , B. J. 1987 . Polymers for biodegradable medical devices. II. Hydroxybutyrate-hydroxyvalerate copolymers: hydrolytic degradation studies . Biomaterials , 8 ( 4 ) : 289 – 295 .
  • Kurcok , P. , Kowalczuk , M. , Adamus , G. , Jedlinski , Z. and Lenz , R. W. 1995 . Degradability of poly (b-hydroxybutyrate)s. Correlation with chemical microstucture . JMS-Pure Appl. Chem. , A32 : 875 – 880 .
  • Bonartsev , A. P. , Myshkina , V. L. , Nikolaeva , D. A. , Furina , E. K. , Makhina , T. A. , Livshits , V. A. , Boskhomdzhiev , A. P. , Ivanov , E. A. , Iordanskii , A. L. and Bonartseva , G. A. 2007 . “ Biosynthesis, biodegradation, and application of poly(3-hydroxybutyrate) and its copolymers - natural polyesters produced by diazotrophic bacteria ” . In Communicating Current Research and Educational Topics and Trends in Applied Microbiology , Edited by: Méndez-Vilas , A. Vol. 1 , 295 – 307 . Spain : Formatex .
  • Bonartsev , A. P. “ private communication ” .
  • Cha , Y. and Pitt , C. G. 1990 . The biodegradability of polyester blends . Biomaterials , 11 ( 2 ) : 108 – 112 .
  • Schliecker , G. , Schmidt , C. , Fuchs , S. , Wombacher , R. and Kissel , T. 2003 . Hydrolytic degradation of poly(lactide-co-glycolide) films: effect of oligomers on degradation rate and crystallinity . Int. J. Pharm. , 266 ( 1–2 ) : 39 – 49 .
  • Scandola , M. , Focarete , M. L. , Adamus , G. , Sikorska , W. , Baranowska , I. , Swierczek , S. , Gnatowski , M. , Kowalczuk , M. and Jedlinski , Z. 1997 . Polymer blends of natural poly(3-hydroxybutyrate-co-hydroxyvalerate) and a synthetic atactic poly(3-hydroxybutyrate). Characterization and biodegradation studies . Macromolecules , 30 : 2568 – 2574 .
  • Doi , Y. , Kanesawa , Y. , Kawaguchi , Y. and Kunioka , M. 1989 . Hydrolytic degradation of microbial poly(hydroxyalkanoates) . Makrom. Chem. Rapid. Commun. , 10 : 227 – 230 .
  • Wang , Y.-W. , Yang , F. , Wu , Q. , Cheng , Y. C. , Yu , P. H. , Chen , J. and Chen , G.-Q. 2005 . Evaluation of three-dimensional scaffolds made of blends of hydroxyapatite and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) for bone reconstruction . Biomaterials , 26 ( 8 ) : 899 – 904 (a) .
  • Muhamad , I. I. , Joon , L. K. and Noor , M. A. M. 2006 . Comparing the degradation of poly-β-(hydroxybutyrate), poly-β–(hydroxybutyrate-co-valerate)(PHBV) and PHBV/Cellulose triacetate blend . Malaysian Polymer J. , 1 : 39 – 46 .
  • Mergaert , J. , Webb , A. , Anderson , C. , Wouters , A. and Swings , J. 1993 . Microbial degradation of poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in soils . Applied and Environmental Microbiology , 59 ( 10 ) : 3233 – 3238 .
  • Choi , G. G. , Kim , H. W. and Rhee , Y. H. 2004 . Enzymatic and non-enzymatic degradation of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolyesters produced by Alcaligenes sp. MT-16 . The Journal of Microbiology , 42 ( 4 ) : 346 – 352 .
  • Yang , X. , Zhao , K. and Chen , G. Q. 2002 . Effect of surface treatment on the biocompatibility of microbial polyhydroxyalkanoates . Biomaterials , 23 ( 5 ) : 1391 – 1397 .
  • Zhao , K. , Yang , X. , Chen , G. Q. and Chen , J. C. 2002 . Effect of lipase treatment on the biocompatibility of microbial polyhydroxyalkanoates . J. material science: materials in medicine , 13 : 849 – 854 .
  • Wang , H. T. , Palmer , H. , Linhardt , R. J. , Flanagan , D. R. and Schmitt , E. 1990 . Degradation of poly(ester) microspheres . Biomaterials , 11 ( 9 ) : 679 – 685 .
  • Doyle , C. , Tanner , E. T. and Bonfield , W. 1991 . In vitro and in vivo evaluation of polyhydroxybutyrate and of polyhydroxybutyrate reinforced with hydroxyapatite . Biomaterials , 12 : 841 – 847 .
  • Coskun , S. , Korkusuz , F. and Hasirci , V. 2005 . Hydroxyapatite reinforced poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) based degradable composite bone plate . J. Biomater. Sci. Polymer Edn. , 16 ( 12 ) : 1485 – 1502 .
  • Sudesh , K. , Abe , H. and Doi , Y. 2000 . Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters . Prog. Polym. Sci. , 25 : 1503 – 1555 .
  • Lobler , M. , Sass , M. , Kunze , C. , Schmitz , K. P. and Hopt , U. T. 2002 . Biomaterial patches sutured onto the rat stomach induce a set of genes encoding pancreatic enzymes . Biomaterials , 23 : 577 – 583 .
  • Tokiwa , Y. , Suzuki , T. and Takeda , K. 1986 . Hydrolysis of polyesters by Rhizopus arrhizus lipase . Agric. Biol. Chem. , 50 : 1323 – 1325 .
  • Hoshino , A. and Isono , Y. 2002 . Degradation of aliphatic polyester films by commercially available lipases with special reference to rapid and complete degradation of poly(L-lactide) film by lipase PL derived from Alcaligenes sp . Biodegradation , 13 : 141 – 147 .
  • Jendrossek , D. , Schirmer , A. and Schlegel , H. G. 1996 . Biodegradation of polyhydroxyalkanoic acids . Appl. Microbiol. Biotechnol. , 46 : 451 – 463 .
  • Winkler , F. K. , D’Arcy , A. and Hunziker , W. 1990 . Structure of human pancreatic lipase . Nature , 343 : 771 – 774 .
  • Mergaert , J. , Anderson , C. , Wouters , A. , Swings , J. and Kersters , K. 1992 . Biodegradation of polyhydroxyalkanoates . FEMS Microbiol. Rev. , 9 ( 2–4 ) : 317 – 321 .
  • Tokiwa , Y. and Calabia , B. P. 2004 . Degradation of microbial polyesters . Biotechnol. Lett. , 26 ( 15 ) : 1181 – 1189 .
  • Mokeeva , V. , Chekunova , L. , Myshkina , V. , Nikolaeva , D. , Gerasin , V. and Bonartseva , G. 2002 . Biodestruction of poly(3-hydroxybutyrate) by microscopic fungi: tests of polymer on resistance to fungi and fungicidal properties . Mikologia and Fitopatologia , 36 ( 5 ) : 59 – 63 .
  • Bonartseva , G. A. , Myshkina , V. L. , Nikolaeva , D. A. , Kevbrina , M. V. , Kallistova , A. Y. , Gerasin , V. A. , Iordanskii , A. L. and Nozhevnikova , A. N. 2003 . Aerobic and anaerobic microbial degradation of poly-beta-hydroxybutyrate produced by Azotobacter chroococcum . Appl Biochem Biotechnol. , 109 ( 1–3 ) : 285 – 301 .
  • Spyros , A. , Kimmich , R. , Briese , B. H. and Jendrossek , D. 1997 . 1H NMR imaging study of enzymatic degradation in poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate). Evidence for preferential degradation of the amorphous phase by PHB depolymerase B from pseudomonas lemoignei . Macromolecules , 30 ( 26 ) : 8218 – 8225 .
  • Hocking , P. J. , Marchessault , R. H. , Timmins , M. R. , Lenz , R. W. and Fuller , R. C. 1996 . Enzymatic degradation of single crystals of bacterial and synthetic poly(-hydroxybutyrate) . Macromolecules , 29 ( 7 ) : 2472 – 2478 .
  • Bonartseva , G. A. , Myshkina , V. L. , Nikolaeva , D. A. , Rebrov , A. V. , Gerasin , V. A. and Makhina , T. K. 2002 . The biodegradation of poly-beta-hydroxybutyrate (PHB) by a model soil community: the effect of cultivation conditions on the degradation rate and the physicochemical characteristics of PHB . Mikrobiologiia , 71 ( 2 ) : 258 – 263 . Russian
  • Kramp , B. , Bernd , H. E. , Schumacher , W. A. , Blynow , M. , Schmidt , W. , Kunze , C. , Behrend , D. and Schmitz , K. P. 2002 . Poly-beta-hydroxybutyric acid (PHB) films and plates in defect covering of the osseus skull in a rabbit model . Laryngorhinootologie , 81 ( 5 ) : 351 – 356 . [Article in German]
  • Malm , T. , Bowald , S. , Karacagil , S. , Bylock , A. and Busch , C. 1992 . A new biodegradable patch for closure of atrial septal defect. An experimental study . Scand. J. Thorac. Cardiovasc. Surg. , 26 ( 1 ) : 9 – 14 (a) .
  • Malm , T. , Bowald , S. , Bylock , A. , Saldeen , T. and Busch , C. 1992 . Regeneration of pericardial tissue on absorbable polymer patches implanted into the pericardial sac. An immunohistochemical, ultrastructural and biochemical study in the sheep . Scandinavian Journal of Thoracic and Cardiovascular Surgery , 26 ( 1 ) : 15 – 21 (b) .
  • Malm , T. , Bowald , S. , Bylock , A. and Busch , C. 1992 . Prevention of postoperative pericardial adhesions by closure of the pericardium with absorbable polymer patches. An experimental study . The Journal of Thoracic and Cardiovascular Surgery , 104 : 600 – 607 (c) .
  • Malm , T. , Bowald , S. , Bylock , A. , Busch , C. and Saldeen , T. 1994 . Enlargement of the right ventricular outflow tract and the pulmonary artery with a new biodegradable patch in transannular position . European Surgical Research , 26 : 298 – 308 .
  • Duvernoy , O. , Malm , T. , Ramström , J. and Bowald , S. 1995, Oct . A biodegradable patch used as a pericardial substitute after cardiac surgery: 6- and 24-month evaluation with CT . Thorac. Cardiovasc. Surg. , 43 ( 5 ) : 271 – 274 .
  • Kawaguchi , T. , Tsugane , A. , Higashide , K. , Endoh , H. , Hasegawa , T. , Kanno , H. , Seki , T. , Juni , K. , Fukushima , S. and Nakano , M. 1992 . Control of drug release with a combination of prodrug and polymer matrix: antitumor activity and release profiles of 2’,3′-Diacyl-5-fluoro-2′-deoxyuridine from poly(3-hydroxybutyrate) microspheres . Journal of Pharmaceutical Sciences , 87 ( 6 ) : 508 – 512 .
  • Baptist , J. N. 1965 . “ Assignor to W.R. Grace Et Co., New York ” . Patent US No. 3 225 766
  • Holmes , P. 1988 . “ Biologically produced (R)-3-hydroxy-alkanoate polymers and copolymers ” . In Developments in Crystalline Polymers , Edited by: Bassett , D. C. Vol. 2 , 1 – 65 . London : Elsevier .
  • Saad , B. , Ciardelli , G. , Matter , S. , Welti , M. , Uhlschmid , G. K. , Neuenschwander , P. and Suterl , U. W. 1996 . Characterization of the cell response of cultured macrophages and fibroblasts td particles of short-chain poly[(R)-3-hydroxybutyric acid] . Journal of Biomedical Materials Research , 30 : 429 – 439 .
  • Fedorov , M. , Vikhoreva , G. , Kildeeva , N. , Maslikova , A. , Bonartseva , G. and Galbraikh , L. 2005 . Modeling of surface modification process of surgical suture . Chimicheskie volokna , : 22 – 28 . [Article in Russian]
  • Rebrov , A. V. , Dubinskii , V. A. , Nekrasov , Y. P. , Bonartseva , G. A. , Shtamm , M. and Antipov , E. M. 2002 . Structure phenomena at elastic deformation of highly oriented polyhydroxybutyrate . Vysokomol. Soedin. (Russian) , 44 : 347 – 351 . [Article in Russian]
  • Kil'deeva , N. R. , Vikhoreva , G. A. , Gal'braikh , L. S. , Mironov , A. V. , Bonartseva , G. A. , Perminov , P. A. and Romashova , A. N. 2006 . Preparation of biodegradable porous films for use as wound coverings . Prikl. Biokhim. Mikrobiol. , 42 ( 6 ) : 716 – 720 . [Article in Russian]
  • Solheim , E. , Sudmann , B. , Bang , G. and Sudmann , E. 2000 . Biocompatibility and effect on osteogenesis of poly(ortho ester) compared to poly(DL-lactic acid) . J. Biomed. Mater. Res. , 49 ( 2 ) : 257 – 263 .
  • Bostman , O. and Pihlajamaki , H. 2000 . Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: a review . Biomaterials , 21 ( 24 ) : 2615 – 2621 .
  • Lickorish , D. , Chan , J. , Song , J. and Davies , J. E. 2004 . An in-vivo model to interrogate the transition from acute to chronic inflammation . Eur. Cell. Mater. , 8 : 12 – 19 .
  • Khouw , I. M. , van Wachem , P. B. , de Leij , L. F. and van Luyn , M. J. 1998 . Inhibition of the tissue reaction to a biodegradable biomaterial by monoclonal antibodies to IFN-gamma . J. Biomed. Mater. Res. , 41 : 202 – 210 .
  • Su , S. H. , Nguyen , K. T. , Satasiya , P. , Greilich , P. E. , Tang , L. and Eberhart , R. C. 2005 . Curcumin impregnation improves the mechanical properties and reduces the inflammatory response associated with poly(L-lactic acid) fiber . J. Biomater. Sci. Polym. Ed. , 16 ( 3 ) : 353 – 370 .
  • Lobler , M. , Sass , M. , Schmitz , K. P. and Hopt , U. T. 2003 . Biomaterial implants induce the inflammation marker CRP at the site of implantation . J. Biomed. Mater. Res. , 61 : 165 – 167 .
  • Novikov , L. N. , Novikova , L. N. , Mosahebi , A. , Wiberg , M. , Terenghi , G. and Kellerth , J. O. 2002 . A novel biodegradable implant for neuronal rescue and regeneration after spinal cord injury . Biomaterials , 23 : 3369 – 3376 .
  • Cao , W. , Wang , A. , Jing , D. , Gong , Y. , Zhao , N. and Zhang , X. 2005 . Novel biodegradable films and scaffolds of chitosan blended with poly(3-hydroxybutyrate) . J. Biomater. Sci. Polymer Edn. , 16 ( 11 ) : 1379 – 1394 .
  • Wang , Y.-W. , Yang , F. , Wu , Q. , Cheng , Y. C. , Yu , P. H. , Chen , J. and Chen , G.-Q. 2005 . Effect of composition of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) on growth of fibroblast and osteoblast . Biomaterials , 26 ( 7 ) : 755 – 761 (b) .
  • Ostwald , J. , Dommerich , S. , Nischan , C. and Kramp , B. 2003 . In vitro culture of cells from respiratory mucosa on foils of collagen, poly-L-lactide (PLLA) and poly-3-hydroxy-butyrate (PHB) . Laryngorhinootologie , 82 ( 10 ) : 693 – 699 . [Article in German]
  • Wollenweber , M. , Domaschke , H. , Hanke , T. , Boxberger , S. , Schmack , G. , Gliesche , K. , Scharnweber , D. and Worch , H. 2006 Feb . Mimicked bioartificial matrix containing chondroitin sulphate on a textile scaffold of poly(3-hydroxybutyrate) alters the differentiation of adult human mesenchymal stem cells . Tissue Eng. , 12 ( 2 ) : 345 – 359 .
  • Wang , Y.-W , Wu , Q. and Chen , G. Q. 2004 . Attachment, proliferation and differentiation of osteoblasts on random biopolyester poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds . Biomaterials , 25 ( 4 ) : 669 – 675 .
  • Nebe , B. , Forster , C. , Pommerenke , H. , Fulda , G. , Behrend , D. , Bernewski , U. , Schmitz , K. P. and Rychly , J. 2001 . Structural alterations of adhesion mediating components in cells cultured on poly-beta-hydroxy butyric acid . Biomaterials , 22 ( 17 ) : 2425 – 2434 .
  • Qu , X.-H. , Wu , Q. and Chen , G.-Q. 2006 . In vitro study on hemocompatibility and cytocompatibility of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) . J. Biomater. Sci. Polymer Edn. , 17 ( 10 ) : 1107 – 1121 (a) .
  • Pompe , T. , Keller , K. , Mothes , G. , Nitschke , M. , Teese , M. , Zimmermann , R. and Werner , C. 2007 . Surface modification of poly(hydroxybutyrate) films to control cell-matrix adhesion . Biomaterials , 28 ( 1 ) : 28 – 37 .
  • Deng , Y. , Lin , X. S. , Zheng , Z. , Deng , J. G. , Chen , J. C. , Ma , H. and Chen , G.-Q. 2003 . Poly(hydroxybutyrate-co-hydroxyhexanoate) promoted production of extracellular matrix of articular cartilage chondrocytes in vitro . Biomaterials , 24 ( 23 ) : 4273 – 4281 .
  • Zheng , Z. , Bei , F.-F. , Tian , H.-L. and Chen , G.-Q. 2005 . Effects of crystallization of polyhydroxyalkanoate blend on surface physicochemical properties and interactions with rabbit articular cartilage chondrocytes . Biomaterials , 26 : 3537 – 3548 .
  • Qu , X.-H. , Wu , Q. , Liang , J. , Zou , B. and Chen , G.-Q. 2006 May . Effect of 3-hydroxyhexanoate content in poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) on in vitro growth and differentiation of smooth muscle cells . Biomaterials , 27 ( 15 ) : 2944 – 2950 (b) .
  • Shishatskaya , E. I. and Volova , T. G. 2004 . A comparative investigation of biodegradable polyhydroxyalkanoate films as matrices for in vitro cell cultures . J. Mater. Sci.-Mater. M. , 15 : 915 – 923 .
  • Fischer , D. , Li , Y. , Ahlemeyer , B. , Kriglstein , J. and Kissel , T. 2003 . In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis . Biomaterials , 24 ( 7 ) : 1121 – 1131 .
  • Nitschke , M. , Schmack , G. , Janke , A. , Simon , F. , Pleul , D. and Werner , C. 2002 . Low pressure plasma treatment of poly(3-hydroxybutyrate): toward tailored polymer surfaces for tissue engineering scaffolds . J. Biomed. Mater. Res. , 59 ( 4 ) : 632 – 638 .
  • Chanvel-Lesrat , D. J. , Pellen-Mussi , P. , Auroy , P. and Bonnaure-Mallet , M. 1999 . Evaluation of the in vitro biocompatibility of various elastomers . Biomaterials , 20 : 291 – 299 .
  • Boyan , B. D. , Hummert , T. W. , Dean , D. D. and Schwartz , Z. 1996 . Role of material surfaces in regulating bone and cartilage cell response . Biomaterials , 17 : 137 – 146 .
  • Bowers , K. T. , Keller , J. C. , Randolph , B. A. , Wick , D. G. and Michaels , C. M. 1992 . Optimization of surface micromorphology for enhanced osteoblasts responses in vitro . Int. J. Oral. Max. Impl. , 7 : 302 – 310 .
  • Cochran , D. , Simpson , J. , Weber , H. and Buser , D. 1994 . Attachment and growth of periodontal cells on smooth and rough titanium . Int. J. Oral. Max. Impl. , 9 : 289 – 297 .
  • Sevastianov , V. I. , Perova , N. V. , Shishatskaya , E. I. , Kalacheva , G. S. and Volova , T. G. 2003 . Production of purified polyhydroxyalkanoates (PHAs) for applications in contact with blood . J. Biomater. Sci. Polym. Ed. , 14 : 1029 – 1042 .
  • Seebach , D. , Brunner , A. , Burger , H. M. , Schneider , J. and Reusch , R. N. 1994 . Isolation and 1H-NMR spectroscopic identification of poly(3-hydroxybutanoate) from prokaryotic and eukaryotic organisms. Determination of the absolute configuration (R) of the monomeric unit 3-hydroxybutanoic acid from Escherichia coli and spinach . Eur. J. Biochem. , 224 ( 2 ) : 317 – 328 .
  • Reusch , R. N. 1989 . Poly-β-hydroxybutryate/calcium polyphosphate complexes in eukaryotic membranes . Proc. Soc. Exp. Biol. Med. , 191 : 377 – 381 .
  • Reusch , R. N. 1992 . Biological complexes of poly-β-hydroxybutyrate . FEMS Microbiol. Rev. , 103 : 119 – 130 .
  • Reusch , R. N. 1995 . Low molecular weight complexed poly(3-hydroxybutyrate): a dynamic and versatile molecule in vivo . Can. J. Microbiol. , 41 ( Suppl. 1 ) : 50 – 54 .
  • Müller , H. M. and Seebach , D. 1994 . Polyhydroxyalkanoates: a fifth class of physiologically important organic biopolymers? . Angew. Chemie. , 32 : 477 – 502 .
  • Huang , R. and Reusch , R. N. 1996 . Poly(3-hydroxybutyrate) is associated with specific proteins in the cytoplasm and membranes of Escherichia coli . J. Biol. Chem. , 271 : 22196 – 22201 .
  • Reusch , R. N. , Bryant , E. M. and Henry , D. N. 2003 . Increased poly-(R)-3-hydroxybutyrate concentrations in streptozotocin (STZ) diabetic rats . Acta Diabetol. , 40 ( 2 ) : 91 – 94 .
  • Reusch , R. N. , Sparrow , A. W. and Gardiner , J. 1992 . Transport of poly-β-hydroxybutyrate in human plasma . Biochim. Biophys. Acta , : 33 – 40 .
  • Reusch , R. N. , Huang , R. and Kosk-Kosicka , D. 1997 . Novel components and enzymatic activities of the human erythrocyte plasma membrane calcium pump . FEBS Lett. , 412 ( 3 ) : 592 – 596 .
  • Pavlov , E. , Zakharian , E. , Bladen , C. , Diao , C. T. M. , Grimbly , C. , Reusch , R. N. and French , R. J. 2005 . A large, voltage-dependent channel, isolated from mitochondria by water-free chloroform extraction . Biophysical Journal , 88 : 2614 – 2625 .
  • Theodorou , M. C. , Panagiotidis , C. A. , Panagiotidis , C. H. , Pantazaki , A. A. and Kyriakidis , D. A. 2006 . Involvement of the AtoS-AtoC signal transduction system in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli . Biochim. Biophys. Acta , 1760 ( 6 ) : 896 – 906 .
  • Wiggam , M. I. , O’Kane , M. J. , Harper , R. , Atkinson , A. B. , Hadden , D. R. , Trimble , E. R. and Bell , P. M. 1997 . Treatment of diabetic ketoacidosis using normalization of blood 3-hydroxy-butyrate concentration as the endpoint of emergency management . Diabetes Care , 20 : 1347 – 1352 .
  • Larsen , T. and Nielsen , N. I. 2005 . Fluorometric determination of beta-hydroxybutyrate in milk and blood plasma . J. Dairy Sci. , 88 ( 6 ) : 2004 – 2009 .
  • Agrawal , C. M. and Athanasiou , K. A. 1997 . Technique to control pH in vicinity of biodegrading PLA-PGA implants . J. Biomed. Mater. Res. , 38 ( 2 ) : 105 – 114 .
  • Ignatius , A. A. and Claes , L. E. 1996 . In vitro biocompatibility of bioresorbable polymers: poly(l, dl-lactide) and poly(l-lactide-co-glycolide) . 17 ( 8 ) : 831 – 839 .
  • Rihova , B. 1996 . Biocompatibility of biomaterials: hemocompatibility, immunocompatibility and biocompatibility of solid polymeric materials and soluble targetable polymeric carriers . Adv. Drug. Delivery Rev. , 21 : 157 – 176 .
  • Ceonzo , K. , Gaynor , A. , Shaffer , L. , Kojima , K. , Vacanti , C. A. and Stahl , G. L. 2006 . Polyglycolic acid-induced inflammation: role of hydrolysis and resulting complement activation . Tissue Eng. , 12 ( 2 ) : 301 – 308 .
  • Chasin , M. and Langer , R. 1990 . Biodegradable Polymers as Drug Delivery Systems , New York : Marcel Dekker .
  • Johnson , O. L. and Tracy , M. A. 1999 . “ Peptide and protein drug delivery ” . In Encyclopedia of Controlled Drug Delivery , Edited by: Mathiowitz , E. Vol. 2 , 816 – 832 . Hoboken , NJ : John Wiley and Sons .
  • Jain , R. A. 2000 . The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices . Biomaterials , 21 : 2475 – 2490 .
  • Gursel , I. and Hasirci , V. 1995 . Properties and drug release behaviour of poly(3-hydroxybutyric acid) and various poly(3-hydroxybutyrate-hydroxyvalerate) copolymer microcapsules . J. Microencapsul. , 12 ( 2 ) : 185 – 193 .
  • Li , J. , Li , X. , Ni , X. , Wang , X. , Li , H. and Leong , K. W. 2006 . Self-assembled supramolecular hydrogels formed by biodegradable PEO–PHB–PEO triblock copolymers and a-cyclodextrin for controlled drug delivery . Biomaterials , 27 : 4132 – 4140 .
  • Akhtar , S. , Pouton , C. W. and Notarianni , L. J. 1992 . Crystallization behaviour and drug release from bacterial polyhydroxyalkanoates . Polymer , 33 ( 1 ) : 117 – 126 .
  • Akhtar , S. , Pouton , C. W. and Notarianni , L. J. 1991 . The influence of crystalline morphology and copolymer composition on drug release from solution cast and melting processed P(HB-HV) copolymer matrices . J. Controlled Release , 17 : 225 – 234 .
  • Korsatko , W. , Wabnegg , B. , Tillian , H. M. , Braunegg , G. and Lafferty , R. M. 1983 . Poly-D-hydroxybutyric acid-a biologically degradable vehicle to regard release of a drug . Pharm. Ind. , 45 : 1004 – 1007 .
  • Korsatko , W. , Wabnegg , B. , Tillian , H. M. , Egger , G. , Pfragner , R. and Walser , V. 1984 . Poly D(-)-3-hydroxybutyric acid (poly-HBA)-a biodegradable former for long-term medication dosage. 3. Studies on compatibility of poly-HBA implantation tablets in tissue culture and animals . Pharm. Ind. , 46 : 952 – 954 .
  • Kassab , A. C. , Piskin , E. , Bilgic , S. , Denkbas , E. B. and Xu , K. 1999 . Embolization with polyhydroxybutyrate (PHB) micromerspheres: in vivo studies . J. Bioact. Compat. Polym. , 14 : 291 – 303 .
  • Kassab , A. C. , Xu , K. , Denkbas , E. B. , Dou , Y. , Zhao , S. and Piskin , E. 1997 . Rifampicin carrying polyhydroxybutyrate microspheres as a potential chemoembolization agent . J. Biomater. Sci. Polym. Ed. , 8 : 947 – 961 .
  • Sendil , D. , Gursel , I. , Wise , D. L. and Hasirci , V. 1999 . Antibiotic release from biodegradable PHBV microparticles . J. Control. Release , 59 : 207 – 17 .
  • Gursel , I. , Yagmurlu , F. , Korkusuz , F. and Hasirci , V. 2002 . In vitro antibiotic release from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) rods . J. Microencapsul. , 19 : 153 – 164 .
  • Turesin , F. , Gursel , I. and Hasirci , V. 2001 . Biodegradable polyhydroxyalkanoate implants for osteomyelitis therapy: in vitro antibiotic release . J. Biomater. Sci. Polym. Ed. , 12 : 195 – 207 .
  • Turesin , F. , Gumusyazici , Z. , Kok , F. M. , Gursel , I. , Alaeddinoglu , N. G. and Hasirci , V. 2000 . Biosynthesis of polyhydroxybutyrate and its copolymers and their use in controlled drug release . Turk. J. Med. Sci. , 30 : 535 – 541 .
  • Gursel , I. , Korkusuz , F. , Turesin , F. , Alaeddinoglu , N. G. and Hasirci , V. 2001 . In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis . Biomaterials , 22 ( 1 ) : 73 – 80 .
  • Korkusuz , F. , Korkusuz , P. , Eksioglu , F. , Gursel , I. and Hasirci , V. 2001 . In vivo response to biodegradable controlled antibiotic release systems . J. Biomed. Mater. Res. , 55 ( 2 ) : 217 – 228 .
  • Yagmurlu , M. F. , Korkusuz , F. , Gursel , I. , Korkusuz , P. , Ors , U. and Hasirci , V. 1999 . Sulbactam-cefoperazone polyhydroxybutyrate-co-hydroxyvalerate (PHBV) local antibiotic delivery system: In vivo effectiveness and biocompatibility in the treatment of implantrelated experimental osteomyelitis . J. Biomed. Mater. Res. , 46 : 494 – 503 .
  • Khang , G. , Kim , S. W. , Cho , J. C. , Rhee , J. M. , Yoon , S. C. and Lee , H. B. 2001 . Preparation and characterization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) microspheres for the sustained release of 5-fluorouracil . Biomed. Mater. Eng. , 11 : 89 – 103 .
  • Bonartsev , A. P. , Bonartseva , G. A. , Makhina , T. K. , Mashkina , V. L. , Luchinina , E. S. , Livshits , V. A. , Boskhomdzhiev , A. P. , Markin , V. S. and Iordanskii , A. L. 2006 . New poly-(3-hydroxybutyrate)-based systems for controlled release of dipyridamole and indomethacin . Prikl. Biokhim. Mikrobiol. , 42 ( 6 ) : 710 – 715 .
  • Salman , M. A. , Sahin , A. , Onur , M. A. , Oge , K. , Kassab , A. and Aypar , U. 2003 . Tramadol encapsulated into polyhydroxybutyrate microspheres: in vitro release and epidural analgesic effect in rats . Acta Anaesthesiol. Scand. , 47 : 1006 – 1012 .
  • Bonartsev , A. P. , Livshits , V. A. , Makhina , T. A. , Myshkina , V. L. , Bonartseva , G. A. and Iordanskii , A. L. 2007 . Controlled release profiles of dipyridamole from biodegradable microspheres on the base of poly(3-hydroxybutyrate) . Express Polymer Letters , 1 ( 12 ) : 797 – 803 (b) .
  • Bonartsev , A. P. , Postnikov , A. B. , Myshkina , V. L. , Artemieva , M. M. and Medvedeva , N. A. 2005 . A new system of nitric oxide donor prolonged delivery on basis of controlled-release polymer, polyhydroxybutyrate . American Journal of Hypertension , 18 ( 5A ) : A
  • Bonartsev , A. P. , Postnikov , A. B. , Mahina , T. K. , Myshkina , V. L. , Voinova , V. V. , Boskhomdzhiev , A. P. , Livshits , V. A. , Bonartseva , G. A. and Iorganskii , A. L. 2007 . A new in vivo model of prolonged local nitric oxide action on arteries on basis of biocompatible polymer . The Journal of Clinical Hypertension , 9 ( 5, Suppl. A. ) : A152 (c)
  • Pouton , C. W. and Akhtar , S. 1996 . Biosynthetic polyhydroxyalkanoates and their potential in drug delivery . Adv. Drug Deliver. Rev. , 18 : 133 – 162 .
  • Kots , A. Y. , Grafov , M. A. , Khropov , Y. V. , Betin , V. L. , Belushkina , N. N. , Busygina , O. G. , Yazykova , M. Y. , Ovchinnikov , I. V. , Kulikov , A. S. , Makhova , N. N. , Medvedeva , N. A. , Bulargina , T. V. and Severina , I. S. 2000 . Vasorelaxant and antiplatelet activity of 4,7-dimethyl-1,2, 5-oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide: role of soluble guanylate cyclase, nitric oxide and thiols . Br. J. Pharmacol. , 129 ( 6 ) : 1163 – 1177 .

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