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ABSTRACT
The RAB class of small GTPases includes the major regulators of intracellular communication, which are involved in vesicle generation through fusion and fission, and vesicular trafficking. RAB proteins also play an imperative role in neuronal maintenance and survival. Recent studies in the field of neurodegeneration have also highlighted the process of autophagy as being essential for neuronal maintenance. Here we review the emerging roles of RAB proteins in regulating macroautophagy and its impact in the context of neurodegenerative diseases.
Abbreviations
| AD | = | Alzheimer disease |
| ATG | = | autophagy related |
| DLB | = | dementia with lewy bodies |
| GTPase | = | guanosine-5′-triphosphatase |
| HD | = | Huntington disease |
| HTT | = | Huntingtin |
| LRRK1 | = | leucine-rich repeat kinase 1 |
| PAS | = | phagophore assembly site |
| PD | = | Parkinson disease |
| RAB | = | Ras related protein in brain |
| TBC | = | Tre-2, Bub2 and Cdc16 domain containing protein |
| ULK1 | = | unc-51 like autophagy activating kinase 1 |
Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.
Acknowledgments
We wish to thank our colleague Ms. Neha Vithani for her help with the figure.
Funding
Work on autophagy in our laboratory is supported by a sponsored research grant from the Science and Engineering Research Board, Department of Science & Technology, Govt. of India (to SG).