803
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Value of 3.0T MRI T2 mapping combined with SWI for the assessment of early lesions in hemophilic arthropathy

, , , &
Pages 1263-1271 | Received 16 Aug 2022, Accepted 09 Nov 2022, Published online: 06 Dec 2022
 

ABSTRACT

Purpose

To explore the value of magnetic resonance imaging (MRI) T2 mapping combined with susceptibility-weighted imaging (SWI) in detecting early cartilage damage and joint bleeding in the hemophilic arthropathy (HA).

Methods

147 patients and 56 healthy controls were prospectively recruited. The knees were divided into groups A and B according to the criteria of the International Cartilage Repair Society (ICRS). The Regions of Interest (ROIs) of T2 mapping were drawn for the patella, lateral and medial femoral condyle, and lateral and medial tibial condyle. The T2 values were compared between the patients and control group using one-way ANOVA. The joint count data of International Prophylaxis Study Group (IPSG) scores of conventional and SWI sequences were statistically described using the composition ratio, and the rank sum test was used for the difference analysis.

Results

Finally, there were 99 joints in the control group, 135 knees in group A, and 94 knees in group B. There was a significant difference between the T2 value in each subgroup. Comparison of T2 value groups in each cartilage partition, except for group A and group B of the patella, revealed significant differences (all P<0.05). SWI was likely more sensitive than conventional sequences in detecting hemosiderin deposits in hemophilic joints. In addition, the IPSG scores detected by the SWI were generally higher than those of conventional sequences.

Conclusions

MR T2 mapping combined with SWI has great potential to be used for detecting early cartilage damage and micro-hemosiderin deposition in hemophiliac arthropathies and developing preventative treatment plans.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by National Natural Science Foundation of China: [Grant Number No. 81271543].