Theoretical modeling expressions for networked enzymatic signal processing steps as logic gates optimized by filtering

Abstract

We describe modeling approaches to a ‘network’ of connected enzyme-catalyzed reactions, with added (bio)chemical processes that introduce biochemical filtering steps into the functioning of such a biocatalytic cascade. Theoretical expressions are derived that allow simple, few-parameter modeling of processes concatenated in such cascades, both with and without filtering. The modeling approach captures and explains features identified in earlier studies of enzymatic processes considered as potential ‘network components’ for multi-step information/signal processing systems.

Keywords:

• Binary AND
• biocatalytic cascade
• biochemical signals
• multi-input biosensor

Acknowledgements

The author thanks his numerous colleagues [4,7,15,16,23,26,30,31,40–42,47,52,53,60,64–71,73–75,104,105], notably, Prof E. Katz, for collaborative team work.