Isolation and identification of a novel sildenafil analogue adulterant in herbal products

Ya-Tze LinDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan (ROC)View further author information

Yen-Chun HuangDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan (ROC)View further author information

Hui-Chun LeeDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan (ROC)Correspondence[email protected]
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Chen-Hsiang LiaoDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan (ROC)View further author information

Yun-Lian LinDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan (ROC)View further author information

Chia-Fen TsaiDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan (ROC)View further author information

Hwei-Fang ChengDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan (ROC)View further author information

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ABSTRACT

A novel sildenafil analogue found in herbal products by a routine drug-adulteration screening programme was isolated by column chromatography. On the basis of extensive 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy and mass spectral analysis, the structure of a new compound YJ-07 was established as 1-[4-ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl) benzenesulfonamide. It common name is aminosildenafil.

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No potential conflict of interest was reported by the authors.

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This work was supported by the Taiwan Food and Drug Administration Fund.

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Isolation and identification of a novel sildenafil analogue adulterant in herbal products

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Isolation and identification of a novel sildenafil analogue adulterant in herbal products

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