The impacts on bone structures and metabolisms by high-fat diet caused osteoporosis in mice: a meta-analysis and systematic review

ABSTRACT

Osteoporosis (OP) is one of the epidemic diseases worldwide. Recently, a high-fat diet (HFD) makes the effects on skeletal microarchitecture still unclear. To explain the problem, we searched studies from PubMed, Embase, Web of Science, and Cochrane library to investigate the effect of HFD-induced obesity on bone structure and metabolism for mice from June 2010 to June 2020. Finally, eight publications were included. The results showed BV/TV was significantly decreased in HFD than control diet (CD) (SMD −4.24, 95% CI: −6.60, −1.87, p < .001), Tb.N (SMD −2.98, 95% CI: −4.89, −1.06, p = .002) and Tb.Th (SMD −1.26, 95% CI: −1.93, −0.59, p < .001) were significantly decreased. Tb.Sp (SMD 2.38, 95% CI:1.04, 3.72, p < .001) and SMI (SMD 3.86, 95% CI: 1.79, 5.93, p < .001) were significantly increased in HFD. In conclusion, HFD accelerated OP progression which reflected on LDL, leptin, osteocalcin (OCN) and osteoprotegerin (OPG).

KEYWORDS:

• Osteoporosis
• high-fat diet
• meta-analysis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Authors’ contributions

QQ Lian and HT Li: study conception and design, participant assessment protocol, data collection, and statistical analysis. QQ Lian and HT Li: manuscript draft preparation. FM Tian: participant assessment, data collection, and review of the manuscript. Y Gou and YP Hu: study conception and design, critical review of the manuscript. L Zhang: study conception and design. All authors have read and approved the final manuscript.

Additional information

Funding

This work was supported by the Doctoral Student Innovation Ability Training Project of Hebei Province (CXZZBS2022107).