![Sample our Environment & Agriculture journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5934/TOC-Subject-Sample-2021-Environment-Agriculture.jpg"})
ABSTRACT
This study delves into the biological characteristics of Clinopodium nepeta subsp. ascendens (CNEO) essential oil, an indigenous subspecies of eastern Morocco. Distinguished by its purple or pale pinkish-white flowers, CNEO was subjected to thorough phytochemical analysis via gas chromatography-mass spectrometry (GC-MS), revealing 21 terpene compounds, notably Dihydrocarvone (22.70%), Neoisomenthol (43.59%), and Pulegone (20.55%). These compounds, recognized for their biological and pharmacological attributes, were further investigated for their potential applications. Notably, CNEO exhibited dose-dependent anti-inflammatory effects by attenuating nitric oxide (NO) and prostaglandin E2 (PGE2) production. Moreover, it demonstrated promising anticancer activity against MDA-MB-468, HepG2, and HCT-15 cancer cell lines, rivaling doxorubicin’s effectiveness. These findings underscore CNEO’s nutraceutical potential, particularly in food science and industry, suggesting its use as a functional food additive with both nutritional and health benefits
Acknowledgments
The authors express their gratitude to the Moroccan Ministry of Higher Education, Scientific Research and Innovation, and the European Union.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Credit authorship contribution statement
Mohamed Taibi: Conceptualization, original draft writing, reviewing, and editing. Amine Elbouzidi: Conceptualization, original draft writing, reviewing, and editing. Mounir Haddou: Conceptualization, original draft writing, reviewing, and editing. Yousra Belbachir: Conceptualization, original draft writing, reviewing, and editing. Abdellah Baraich: Conceptualization, original draft writing, reviewing, and editing. Zineb Khalil: Original draft writing, reviewing, and editing. Reda Bellaouchi: Formal analysis, investigations, funding acquisition, reviewing, and editing. Abdeslam Asehraou: Formal analysis, investigations, funding acquisition, reviewing, and editing. Mohamed Addi: Formal analysis, investigations, funding acquisition, reviewing, and editing. Ammar AL-Farga: Resources, data validation, and data curation. Saleh M. Al-Maaqar: Resources, data validation, an data curation. Bouchra El Guerrouj: Resources, data validation, data curation, and supervision. Khalid Chaabane: Resources, data validation, data curation, and supervision.
Data availability statement
Data will be available upon request from the corresponding author.