1,143
Views
22
CrossRef citations to date
0
Altmetric
Letter to the editor

M-ficolin is present in Aspergillus fumigatus infected lung and modulates epithelial cell immune responses elicited by fungal cell wall polysaccharides

, , , , , , , , , , & show all
Pages 1870-1879 | Received 23 Nov 2016, Accepted 28 Dec 2016, Published online: 16 Feb 2017
 

Abbreviations

acBSA=

acetylated BSA

A. fumigatus=

Aspergillus fumigatus

AIF=

alkali-insoluble fraction

BSA=

bovine serum albumin

CHO cells=

Chinese hamster ovary cells

CS=

culture supernatant

CM=

complete medium

FReDs=

fibrinogen-related domains

GlcNAc=

N-acetylglucosamine

IL-8=

interleukin 8

MASP-2=

MBL-associated serine protease 2

MBL=

mannan-binding lectin

ON=

overnight

rM-ficolin=

recombinant M-ficolin

RT=

room temperature.

S. typhimurium=

Salmonella typhimurium

TRIFMA=

time-resolved fluorometry

WGA=

wheat germ agglutinin

Disclosure of potential conflicts of interest

No potential conflicts of interest were disclosed.

Acknowledgments

Jensen-K, Lund-KP, Christensen-KB, Holm-AT, Jepsen-CS, Dubey-LK and Galgóczy-L performed experiments; Jensen-K, Lund-KP and Sorensen-GL wrote the manuscript; Moeller-JB, Schlosser-A, Thiel-S, Holmskov-U and Sorensen-GL designed experiments; Thiel-S and Sorensen-GL conceived study; all co-authors approved final version of the manuscript.

Funding

We would like to thank technician Lisbeth Jensen, Aarhus University, and Karen E. Olsen and Ole Nielsen, Department of Pathology, Odense University Hospital, for all of the help and support with providing and interpreting the immunohistochemical sections. L.G. was supported by a Lise Meitner fellowship (M1776-B20) from the Austrian Science Fund (FWF) and the Postdoctoral Excellence Program (PD 120808) of the Hungarian National Research, Development and Innovation Office (NKFI Office). The Danish Research Council for Independent Research further supported this study.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.