Bacterial interaction with host autophagy

ABSTRACT

Autophagy is a conserved and fundamental cellular process mainly to recycle or eliminate dysfunctional cellular organelles or proteins. As a response to cellular stress, autophagy is used as a defense mechanism to combat the infection with pathogenic bacteria. However, many intracellular bacteria have developed diverse mechanisms to evade recognition, to manipulate the autophagic pathway, and to hijack the autophagosomal compartment for replication. In this review, we discuss recent understandings on how bacteria interact with host autophagy.

KEYWORDS:

• Intracellular bacteria
• autophagy
• autophagosome
• bacterial effectors
• autophagy pathways

Acknowledgments

This work was supported by the European Research Council, ERC (ChemBioAP), Knut and Alice Wallenberg Foundation and Vetenskapsrådet (Nr. 2018–04585) to Y.W.W.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the H2020 European Research Council [ChemBioAP]; Knut och Alice Wallenbergs Stiftelse [WAF]; Vetenskapsrådet [2018-04585].