Photodynamic treatment modulates various GTPase and cellular signalling pathways in Tauopathy

ABSTRACT

The application of photo-excited dyes for treatment is known as photodynamic therapy (PDT). PDT is known to target GTPase proteins in cells, which are the key proteins of diverse signalling cascades which ultimately modulate cell proliferation and death. Cytoskeletal proteins play critical roles in maintaining cell integrity and cell division. Whereas, it was also observed that in neuronal cells PDT modulated actin and tubulin resulting in increased neurite growth and filopodia. Recent studies supported the role of PDT in dissolving the extracellular amyloid beta aggregates and intracellular Tau aggregates, which indicated the potential role of PDT in neurodegeneration. The advancement in the field of PDT led to its clinical approval in treatment of cancers, brain tumour, and dermatological acne. Although several question need to be answered for application of PDT in neuronal cells, but the primary studies gave a hint that it can emerge as potential therapy in neural cells.

KEYWORDS:

• Photodynamic therapy
• photosensitizers
• GTPase
• neurodegeneration
• clinical application

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All authors consent to the publication.

Acknowledgments

Tushar Dubey acknowledges the fellowship from University Grant Commission (UGC), India. We thank Chinnathambi’s lab people for their fruitful discussion on manuscript.

Disclosure statement

The authors declare that they have no competing interests.

Author contributions

TD and SC collected and reviewed the literature and wrote the manuscript. SC conceived the idea for the project, resource provided, supervised and wrote the manuscript. Both the authors read and approved the final manuscript.

Additional information

Funding

This project is supported in part by grant from in-house CSIR-National Chemical Laboratory grant MLP101726.