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Abstract
Many diseases are associated with oxidative stress caused by reactive oxygen species and free radicals generated in living cells. This study deals with finding naturally occurring antioxidants of plant origin. The study investigated the phytochemistry, antioxidant and free radical scavenging potential of ethanolic leaf extract of Adhatoda vasica (ELEAV) using different antioxidant models. The phytochemical analysis of ELEAV revealed the presence of alkaloids, flavonoids, terpenoids, saponins, phenols and steroids. ELEAV also showed an antioxidant capacity, with inhibition of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical by 69.23%. ELEAV had potent inhibitory effects on scavenging nitric oxide, superoxide and hydroxyl radicals, by 65.24%, 61.54% and 61.24%, respectively. Moreover, ELEAV displayed a concentration-dependent reducing power activity and potent inhibitory effects on ferric ion-induced lipid peroxidation (68.26%) in bovine brain extract. These findings confirm the biological efficacy of A. vasica as a potential source of natural antioxidants.
Disclosure statement
No potential conflict of interest was reported by the authors.