The mutually regulatory loop of epithelial–mesenchymal transition and immunosuppression in cancer progression

Limo ChenDepartment of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA

John V HeymachDepartment of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA

F Xiao-Feng QinDepartment of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA;Center of Systems Medicine, Institute of Basic Medical Sciences, Suzhou, China;Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaCorrespondence[email protected] [email protected]

Don L GibbonsDepartment of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center; Houston, TXUSA;Department of Molecular and Cellular Oncology; The University of Texas MD Anderson Cancer Center; Houston, TXUSACorrespondence[email protected] [email protected]

Abstract

Epithelial–mesenchymal transition and immunosuppression are crucial for cancer metastasis and treatment resistance. The mechanism by which these distinct processes are co-opted remains incompletely understood. Our recent work has exposed the “dirty affairs” of the 2 at the tumor site, thus calling for a combined therapy to break such a dangerous liaison.

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No potential conflicts of interest were disclosed.

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The mutually regulatory loop of epithelial–mesenchymal transition and immunosuppression in cancer progression

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The mutually regulatory loop of epithelial–mesenchymal transition and immunosuppression in cancer progression

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