Time to Akt

Abstract

T cells are crucial players in the protection against cancer, and can be used in adoptive cell therapy to prevent or treat relapse. However, their state of differentiation determines their effectiveness, with early memory cells being the most favorable. Here, we discuss restraining of differentiation to engineer the ultimate tumor-reactive T cell.

Keywords:

• adoptive T cell therapy
• Akt
• dendritic cell
• IL-7
• IL-15
• stem cell transplantation
• T-cell differentiation
• Wnt

Abbreviations:

• ACT: adoptive cell therapy
• Allo-SCT: allogeneic stem cell transplantation
• APC: antigen-presenting cells
• CAR: chimeric antigen receptor
• DCs: dendritic cells
• MiHAs: minor histocompatibility antigens
• T_cm: central memory T
• TCR: T-cell receptor
• T_eff: effector T
• T_em: effector memory T
• TILs: tumor-infiltrating lymphocytes
• T_n: naive T
• T_scm: stem cell memory T

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.