HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictor of chemosensitivity in ovarian cancer

Abstract

Cytotoxic T lymphocytes (CTLs) recognize the human leukocyte antigen (HLA) class I and antigenic peptide complex, and they play a crucial role in cancer immunity. Our recent study revealed that HLA class I downregulation is related to poorer prognosis and a low level of intratumoral CTLs is associated with platinum resistance, indicating the significance of immunological surveillance.

Keywords:

• CTL
• HLA class I
• ovarian cancer
• platinum resistance

Abbreviations:

• CTL, cytotoxic T lymphocyte
• HLA, human leukocyte antigen
• MHC, major histocompatibility complex
• TAA, tumor-associated antigen

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Funding

This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to Noriyuki Sato, Toshihiko Torigoe, and Yoshihiko Hirohashi), the program for developing the supporting system for upgrading education and research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to Noriyuki Sato), the Takeda Science Foundation (to Yoshihiko Hirohashi), the Sagawa Foundation for Promotion of Cancer Research (to Yoshihiko Hirohashi), Suharakinennzaidann Co., Ltd. (to Yoshihiko Hirohashi), and the Kobayashi Foundation for Cancer Research (to Yoshihiko Hirohashi).