Splenectomy restores tumoricidal activity to promote elimination of intraocular tumors

Abstract

We recently demonstrated that splenectomy restores an interaction between CD8⁺ T cells and macrophages necessary for intraocular tumor elimination. Taking into consideration other studies indicating that intraocular tumor growth does not induce tumor-specific CD8⁺ T-cell tolerance, our data suggest that splenectomy may influence the phenotype of tumor-associated macrophages.

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.