OncoImmunology, Volume 4, Issue 7 (2015)

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OncoImmunology, Volume 4, Issue 7 (2015)

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Editorial

Colorectal cancer: the first neoplasia found to be under immunosurveillance and the last one to respond to immunotherapy?
Guido Kroemer, Lorenzo Galluzzi, Laurence Zitvogel & Wolf Hervé Fridman
Article: e1058597
Published online: 17 Jun 2015
AbstractforColorectal cancer: the first neoplasia found to be under immunosurveillance and the last one to respond to immunotherapy? | Full Text | References | PDF (63.7 KB)
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Combinatorial immunotherapy with checkpoint blockers solves the problem of metastatic melanoma—An exclamation sign with a question mark
Guido Kroemer & Lorenzo Galluzzi
Article: e1058037
Published online: 17 Jun 2015
AbstractforCombinatorial immunotherapy with checkpoint blockers solves the problem of metastatic melanoma—An exclamation sign with a question mark | Full Text | References | PDF (64.6 KB)
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Author's View

Article
Kick-starting the cancer-immunity cycle by targeting CD40
P Ellmark, S M Mangsbo, C Furebring, T H Tötterman & P Norlén
Article: e1011484
Published online: 17 Jun 2015
AbstractforKick-starting the cancer-immunity cycle by targeting CD40 | Full Text | References | PDF (153.6 KB)
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Article
Splenectomy restores tumoricidal activity to promote elimination of intraocular tumors
Kyle C McKenna
Article: e1011516
Published online: 17 Jun 2015
AbstractforSplenectomy restores tumoricidal activity to promote elimination of intraocular tumors | Full Text | References | PDF (119.3 KB)
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Article
Depletion of regulatory T cells by targeting CC chemokine receptor type 4 with mogamulizumab
Xiao Ni, Timothy Langridge & Madeleine Duvic
Article: e1011524
Published online: 17 Jun 2015
AbstractforDepletion of regulatory T cells by targeting CC chemokine receptor type 4 with mogamulizumab | Full Text | References | PDF (165 KB)
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Article
Antileukemia T-cell responses in CLL – We don't need no aberration
Daniel J Kowalewski, Stefan Stevanovic, Hans-Georg Rammensee & Juliane S Stickel
Article: e1011527
Published online: 17 Jun 2015
AbstractforAntileukemia T-cell responses in CLL – We don't need no aberration | Full Text | References | PDF (262 KB)
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Article
“In situ” vaccination for systemic effects in follicular lymphoma
Arne Kolstad & Johanna Olweus
Article: e1014773
Published online: 17 Jun 2015
Abstractfor“In situ” vaccination for systemic effects in follicular lymphoma | Full Text | References | PDF (175.8 KB) | Supplemental
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Article
Deficient regulatory B cells in human chronic graft-versus-host disease
Adèle de Masson, Gérard Socié, Martine Bagot, Armand Bensussan & Jean-David Bouaziz
Article: e1016707
Published online: 17 Jun 2015
AbstractforDeficient regulatory B cells in human chronic graft-versus-host disease | Full Text | References | PDF (219.2 KB)
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Article
The antitumor immune response generated by fractionated radiation therapy may be limited by tumor cell adaptive resistance and can be circumvented by PD-L1 blockade
S J Dovedi & T M Illidge
Article: e1016709
Published online: 17 Jun 2015
AbstractforThe antitumor immune response generated by fractionated radiation therapy may be limited by tumor cell adaptive resistance and can be circumvented by PD-L1 blockade | Full Text | References | PDF (173.6 KB)
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Article
Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies
Tana Omokoko, Petra Simon, Özlem Türeci & Ugur Sahin
Article: e1005523
Published online: 17 Jun 2015
AbstractforRetrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies | Full Text | References | PDF (183.7 KB)
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Review

Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells
Annie A Wu, Virginia Drake, Huai-Shiuan Huang, ShihChi Chiu & Lei Zheng
Article: e1016700
Published online: 17 Jun 2015
AbstractforReprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells | Full Text | References | PDF (270.2 KB)
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Brief Report

Brief Report
Strong spontaneous tumor neoantigen responses induced by a natural human carcinogen
Jenette Creaney, Shaokang Ma, Sophie A Sneddon, Michelle R Tourigny, Ian M Dick, Justine S Leon, Andrea Khong, Scott A Fisher, Richard A Lake, W Joost Lesterhuis, Anna K Nowak, Shay Leary, Mark W Watson & Bruce W Robinson
Article: e1011492
Published online: 17 Jun 2015
AbstractforStrong spontaneous tumor neoantigen responses induced by a natural human carcinogen | Full Text | References | PDF (436.8 KB)
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Brief Report
Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8+ T-cell response and robust cellular and transcriptional immune activation at tumor site in a patient with ovarian cancer
L Vassilev, T Ranki, T Joensuu, E Jäger, J Karbach, C Wahle, K Partanen, K Kairemo, T Alanko, R Turkki, N Linder, J Lundin, A Ristimäki, M Kankainen, A Hemminki, C Backman, K Dienel, M von Euler, E Haavisto, T Hakonen, J Juhila, M Jäderberg, P Priha, A Vuolanto & S Pesonen
Article: e1017702
Published online: 17 Jun 2015
AbstractforRepeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8+ T-cell response and robust cellular and transcriptional immune activation at tumor site in a patient with ovarian cancer | Full Text | References | PDF (343.7 KB)
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Original Research

IL-10 enhances CTL-mediated tumor rejection by inhibiting highly suppressive CD4+ T cells and promoting CTL persistence in a murine model of plasmacytoma
Lixin Wang, Jin-Qing Liu, Fatemeh Talebian, Zhenzhen Liu, Li Yu & Xue-Feng Bai
Article: e1014232
Published online: 17 Jun 2015
AbstractforIL-10 enhances CTL-mediated tumor rejection by inhibiting highly suppressive CD4+ T cells and promoting CTL persistence in a murine model of plasmacytoma | Full Text | References | PDF (612.8 KB)
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Immunoglobulin-like transcript 3 is expressed by myeloid-derived suppressor cells and correlates with survival in patients with non-small cell lung cancer
Pauline L de Goeje, Koen Bezemer, Marlies E Heuvers, Anne-Marie C Dingemans, Harry Jm Groen, Egbert F Smit, Henk C Hoogsteden, Rudi W Hendriks, Joachim Gjv Aerts & Joost Pjj Hegmans
Article: e1014242
Published online: 17 Jun 2015
AbstractforImmunoglobulin-like transcript 3 is expressed by myeloid-derived suppressor cells and correlates with survival in patients with non-small cell lung cancer | Full Text | References | PDF (655.8 KB)
  • 2236 Views
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Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation
Karin Schilbach, Mohammed Alkhaled, Christian Welker, Franziska Eckert, Gregor Blank, Hendrik Ziegler, Marco Sterk, Friederike Müller, Katja Sonntag, Thomas Wieder, Heidi Braumüller, Julia Schmitt, Matthias Eyrich, Sabine Schleicher, Christian Seitz, Annika Erbacher, Bernd J Pichler, Hartmut Müller, Robert Tighe, Annick Lim, Stephen D Gillies, Wolfgang Strittmatter, Martin Röcken & Rupert Handgretinger
Article: e1014760
Published online: 17 Jun 2015
AbstractforCancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation | Full Text | References | PDF (1.3 MB) | Supplemental
  • 3235 Views
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Article
Local Salmonella immunostimulation recruits vaccine-specific CD8 T cells and increases regression of bladder tumor
Sonia Domingos-Pereira, Rim Hojeij, Erica Reggi, Laurent Derré, Mathieu F Chevalier, Pedro Romero, Patrice Jichlinski & Denise Nardelli-Haefliger
Article: e1016697
Published online: 17 Jun 2015
AbstractforLocal Salmonella immunostimulation recruits vaccine-specific CD8 T cells and increases regression of bladder tumor | Full Text | References | PDF (690.6 KB)
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Article
Ikaros deficiency in host hematopoietic cells separates GVL from GVHD after experimental allogeneic hematopoietic cell transplantation
Tomomi Toubai, Hou Guoqing, Corrine Rossi, Nathan Mathewson, Katherine Oravecz-Wilson, Emily Cummings, Julia Wu, Yaping Sun, Sung Choi & Pavan Reddy
Article: e1016699
Published online: 17 Jun 2015
AbstractforIkaros deficiency in host hematopoietic cells separates GVL from GVHD after experimental allogeneic hematopoietic cell transplantation | Full Text | References | PDF (829 KB)
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Article
Prolonged progression-free survival after consolidating second or later remissions of neuroblastoma with Anti-GD2 immunotherapy and isotretinoin: a prospective Phase II study
Brian H Kushner, Irina Ostrovnaya, Irene Y Cheung, Deborah Kuk, Kim Kramer, Shakeel Modak, Karima Yataghene & Nai-Kong V Cheung
Article: e1016704
Published online: 17 Jun 2015
AbstractforProlonged progression-free survival after consolidating second or later remissions of neuroblastoma with Anti-GD2 immunotherapy and isotretinoin: a prospective Phase II study | Full Text | References | PDF (334.2 KB)
  • 2019 Views
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Article
Restoration of natural killer activity in hepatocellular carcinoma by treatment with antibody against granulin-epithelin precursor
Phyllis FY Cheung, Chi Wai Yip, Linda WC Ng, Chun Kwok Wong, Tan To Cheung, Chung Mau Lo, Sheung Tat Fan & Siu Tim Cheung
Article: e1016706
Published online: 17 Jun 2015
AbstractforRestoration of natural killer activity in hepatocellular carcinoma by treatment with antibody against granulin-epithelin precursor | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1186 Views
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Article
Combined IL-15 and IL-12 drives the generation of CD34+-derived natural killer cells with superior maturation and alloreactivity potential following adoptive transfer
Jeannette Cany, Anniek B van der Waart, Jan Spanholtz, Marleen Tordoir, Joop H Jansen, Robbert van der Voort, Nicolaas M Schaap & Harry Dolstra
Article: e1017701
Published online: 17 Jun 2015
AbstractforCombined IL-15 and IL-12 drives the generation of CD34+-derived natural killer cells with superior maturation and alloreactivity potential following adoptive transfer | Full Text | References | PDF (910.9 KB) | Supplemental
  • 2117 Views
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Epstein-Barr virus-induced gene 3-deficiency leads to impaired antitumor T-cell responses and accelerated tumor growth
Zhenzhen Liu, Jin-Qing Liu, Yun Shi, Xiaotong Zhu, Zhihao Liu, Ming-Song Li, Jianhua Yu, Lai-Chu Wu, Yukai He, Guoqiang Zhang & Xue-Feng Bai
Article: e989137
Published online: 17 Jun 2015
AbstractforEpstein-Barr virus-induced gene 3-deficiency leads to impaired antitumor T-cell responses and accelerated tumor growth | Full Text | References | PDF (810.2 KB)
  • 1059 Views
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Cross-talk between tumors can affect responses to therapy
Christel Devaud, Liza B John, Jennifer A Westwood, Carmen SM Yong, Paul A Beavis, Reto A Schwendener, Phillip K Darcy & Michael H Kershaw
Article: e975572
Published online: 17 Jun 2015
AbstractforCross-talk between tumors can affect responses to therapy | Full Text | References | PDF (876.4 KB)
  • 601 Views
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A phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer
Noemí Eiró, Belen Fernandez-Garcia, Julio Vázquez, José M del Casar, Luis O González & Francisco J Vizoso
Article: e992222
Published online: 17 Jun 2015
AbstractforA phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer | Full Text | References | PDF (1 MB) | Supplemental
  • 1005 Views
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